Efficacy and safety of ribosome-component immune modulator for preventing recurrent respiratory infections in socialized children

Allergy and Asthma Proceedings

Volumn 33, Issue 2, 2012, Pages 197-204

  Fiocchi, Alessandro ^a   Omboni, Stefano ^b   Mora, Renzo ^c   Macchi, Alberto ^d   Nespoli, Luigi ^d   Arrigoni, Sergio ^a   Guastini, Luca ^c   Castelnuovo, Paolo ^d   Graziani, Daniela ^d   Marcassa, Sergio ^e  

^a Melloni University Hospital   (Italy)

^b ITALIAN INSTITUTE OF TELEMEDICINE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e Centre d'Immunologie Pierre Fabre   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMUNIL; PLACEBO; RIBOMUNYL; RIBOVAC; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; APPENDICITIS; ARM FRACTURE; ARTICLE; BRONCHITIS; CATARRH; CHICKENPOX; CHILD; CONJUNCTIVAL HYPEREMIA; CONJUNCTIVITIS; CONTROLLED STUDY; CYSTITIS; DAY CARE; DIARRHEA; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FEVER; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; ERYTHEMA INFECTIOSUM; FEMALE; FOLLOW UP; GASTROENTERITIS; GROUPS BY AGE; HEAD INJURY; HEMATOMA; HUMAN; IMPETIGO; INFECTION; INFECTION PREVENTION; INFECTION RISK; INFECTIOUS PNEUMONIA; INFLUENZA; INJURY; LARYNX SPASM; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; MUCOSA INFLAMMATION; MULTICENTER STUDY; OCULAR PRURITUS; OTALGIA; OTITIS MEDIA; PATIENT COMPLIANCE; PEDICULOSIS; PHARYNGITIS; PITYRIASIS ROSEA; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RECURRENT INFECTION; RESPIRATORY TRACT INFECTION; RHINITIS; SCARLET FEVER; SINUSITIS; STOMATITIS; TONSILLITIS; TOOTH ABSCESS; TRACHEITIS; TREATMENT OUTCOME; URTICARIA; VOMITING; WELLBEING; WHITLOW;

ANTIGENS, BACTERIAL; CHILD DAY CARE CENTERS; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; ITALY; MALE; RECURRENCE; RESPIRATORY TRACT INFECTIONS; TREATMENT OUTCOME;

EID: 84860227686     PISSN: 10885412     EISSN: 15396304     Source Type: Journal    
DOI: 10.2500/aap.2012.33.3516     Document Type: Article

References (24)

1. Graham NM. The epidemiology of acute respiratory infections in children and adults: A global perspective. Epidemiol Rev 12:149-178, 1990.
2. Wei SC, and Norwood J. Diagnosis and management of respiratory tract infections for the primary care physician. Obstet Gynecol Clin North Am 28:283-304, 2001. (Pubitemid 32544569)
3. McGrath-Morrow SA, Lee G, Stewart BH, et al. Day care increases the risk of respiratory morbidity in chronic lung disease of prematurity. Pediatrics 126:632-637, 2010.
4. Kubba H, Swan IR, and Gatehouse S. Measuring quality of life in preschool children with sore throats and otitis media using the TAPQOL questionnaire. Otolaryngol Head Neck Surg 132:647-652, 2005. (Pubitemid 40460900)
5. de Martino M, and Ballotti S. The child with recurrent respiratory infections: Normal or not? Pediatr Allergy Immunol 18(suppl 18):13-18, 2007. (Pubitemid 47340813)
6. Fiocchi A, Olivieri D, Marcassa S, et al. Cost effective analysis of ribosome-component immune modulation. Allergy Asthma Proc 30(suppl 1):S37-S39, 2009.
7. Pregliasco F, Terracciano L, Marcassa S, et al. Rationale for the clinical use of a ribosome-component immune modulator. Allergy Asthma Proc 30(suppl 1):S5-S12, 2009.
8. Bellanti J, Olivieri D, and Serrano E. Ribosomal immunostimulation: Assessment of studies evaluating its clinical relevance in the prevention of upper and lower respiratory tract infections in children and adults. BioDrugs 17:355-367, 2003. (Pubitemid 37271866)
9. Olivieri D, Fiocchi A, Pregliasco F, et al. Safety and tolerability of ribosome-component immune modulator in adults and children. Allergy Asthma Proc 30(suppl 1):S33-S36, 2009.
10. Fiocchi A, Terracciano L, Martelli A, et al. Ribosome-component immune modulation of respiratory tract infections in children. Allergy Asthma Proc 30(suppl 1):S21-S31, 2009.
11. Vautel JM, Cauqil J, Perruchet AM, and Thomas AM. Prevention of recurrent ear, nose, and throat infections in young children with Ribomunyl: Double-blind placebo-controlled study. Curr Ther Res 53:722-729, 1993. (Pubitemid 23261649)
12. Haguenauer JP. Prévention des épisodes infectieux récidivants de la sphère ORL par Ribomunyl comprimés chez l'enfant de moin de 5 ans. Immunol Med 18:36-39, 1987.
13. Martín-Gil D, Diéguez I, Oehling A, and Subirá ML. Immunotherapy with bacterial ribosomal antigen. I. Clinical study. Allergol Immunopathol (Madr) 9:509-518, 1981. (Pubitemid 12140503)
14. Information from your family doctor. Runny nose and your child's cold. Am Fam Physician 2:2698, 2000.
15. Kusel MM, de Klerk NH, Kebadze T, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 119:1105-1110, 2007. (Pubitemid 46654175)
16. Berber A, and Del-Rio-Navarro B. Compilation and meta-analysis of randomized placebo-controlled clinical trials on the prevention of respiratory tract infections in children using immunostimulants. J Investig Allergol Clin Immunol 11:235-246, 2001. (Pubitemid 34230130)
17. Del-Rio-Navarro BE, Espinosa Rosales F, Flenady V, and Sienra-Monge JJ. Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 4:CD004974, 2006. (Updated March 3, 2011.)
18. Mira E, and Benazzo M. Ruolo di un preparato immunostimolante costitutito da frazioni ribosomi ali batteriche e da proteoglicani di membrana di K. Pneumoniae nella prevenzione delle infezioni respiratorie e otorinolaringoiatriche. J Clin Med 1:1-15, 2003.
19. Bousquet J, and Fiocchi A. Prevention of recurrent respiratory tract infections in children using a ribosomal immunotherapeutic agent: A clinical review. Paediatr Drugs 8:235-243, 2006.
20. Mora R, Dellepiane M, Crippa B, and Salami A. Ribosomal therapy in the prophylaxis of recurrent pharyngotonsillitis in children. Int J Pediatr Otorhinolaryngol 71:257-261, 2007. (Pubitemid 46075151)
21. Boyle P, Bellanti JA, and Robertson C. Meta-analysis of published clinical trials of a ribosomal vaccine (ribomunyl) in prevention of respiratory infections. BioDrugs 14:389-408, 2000. (Pubitemid 32105547)
22. Hü ls P, Welbers P, and Lindemann H. Immuntherapie bei kindern mit hilfe eines multibakteriellen ribosomenpräparates. Der Kinderarzt 26:1018-1024, 1995.
23. Lacomme Y, and Nancy P. Prévention par immunothérapie ribosomale des épisodes de surinfection récidivante de la sphère ORL chez l'enfant: Résultats cliniques d'une étude multicentrique. Immunologie Med 11:73-75, 1985.
24. Williams BG, Gouws E, Boschi-Pinto C, et al. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis 2:25-32, 2002. (Pubitemid 36109303)