Understanding diabetic polyneuropathy and longevity: What can we learn from the nematode Caenorhabditis elegans?

Experimental and Clinical Endocrinology and Diabetes

Volumn 120, Issue 4, 2012, Pages 182-183

  Mendler, M ^a   Schlotterer, A ^a   Morcos, M ^a   Nawroth, P P ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Caenorhabditis elegans; diabetes mellitus; glucotoxic damage; insulin; neuropathy; oxidative stress

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN;

AGING; CAENORHABDITIS ELEGANS; DIABETIC NEUROPATHY; DIABETIC PATIENT; DISEASE MODEL; GENETIC CODE; HUMAN; LONGEVITY; NERVE FUNCTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VULVA DISEASE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; COMPREHENSION; DIABETIC NEUROPATHIES; DISEASE MODELS, ANIMAL; HUMANS; LONGEVITY;

EID: 84860226772     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0032-1304570     Document Type: Review

References (7)

1. Koster I, Huppertz E, Hauner H et al. Direct costs of diabetes mellitus in Germany - CoDiM 2000-2007. Exp Clin Endocrinol Diabetes: 2011; 119 06 377 385 10.1055/s-0030-1269847
2. Pham M, Oikonomou D, Baumer P et al. Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy: findings of high-resolution magnetic resonance neurography. Diabetes Care: 2011; 34 03 721 723 dc10-1491[pii]10.2337/ dc10-1491
3. Kenyon C, Chang J, Gensch E et al. A C. elegans mutant that lives twice as long as wild type. Nature: 1993; 366 6454 461 464 10.1038/366461a0 (Pubitemid 24013878)
4. Lee S J, Murphy C T, Kenyon C. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab: 2009; 10 05 379 391 S1550-4131(09)00302-7[pii]10.1016/j.cmet.2009. 10.003
5. Schlotterer A, Kukudov G, Bozorgmehr F et al. C. elegans as model for the study of high glucose-mediated life span reduction. Diabetes: 2009; 58 11 2450 2456 db09-0567[pii]10.2337/db09-0567
6. Bornhaupt T. Wormtracker. Neustadt adW Germany
7. Morcos M, Du X, Pfisterer F et al. Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans. Aging Cell: 2008; 7 02 260 269 ACE371[pii]10.1111/j.1474-9726.2008.00371.x (Pubitemid 351359658)