Assay validation of phosphorylated S6 ribosomal protein for a pharmacodynamic monitoring of mTOR-inhibitors in peripheral human blood

Cytometry Part B - Clinical Cytometry

Volumn 82 B, Issue 3, 2012, Pages 151-157

  Dieterlen, Maja Theresa ^a   Bittner, Hartmuth B ^a   Klein, Sara ^a   Von Salisch, Sandy ^a   Mittag, Anja ^a   Tárnok, Attila ^a   Dhein, Stefan ^a   Mohr, Friedrich W ^a   Barten, Markus J ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

mTOR inhibitor; pharmacodynamic; pharmacokinetic; phospho flow cytometry; S6 ribosomal protein; therapeutic drug monitoring

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; IMMUNOSUPPRESSIVE AGENT; IONOMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHORYLATED S6 RIBOSOMAL PROTEIN; RAPAMYCIN; RIBOSOME PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BLOOD; CONTROLLED STUDY; DRUG EFFECT; DRUG MONITORING; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INTERMETHOD COMPARISON; ORGAN TRANSPLANTATION; PHARMACODYNAMICS; PRIORITY JOURNAL; T LYMPHOCYTE; VALIDATION PROCESS;

CYCLOSPORINE; DEXAMETHASONE; DRUG MONITORING; FLOW CYTOMETRY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MYCOPHENOLIC ACID; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6; SIROLIMUS; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES;

EID: 84860219637     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.21005     Document Type: Article

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