C-Myc Is required for proper coronary vascular formation via cell-and gene-specific signaling

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 5, 2012, Pages 1308-1319

  Souders, Colby A ^a   Bowers, Stephanie L K ^a   Banerjee, Indroneal ^b   Fuseler, John W ^c   Demieville, Jennifer L ^a   Baudino, Troy A ^a,d  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; C Myc; Cardiac fibroblasts; Endothelial cells; Hypertrophy

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPOIETIN 1; CONNECTIVE TISSUE GROWTH FACTOR; CXCL2 CHEMOKINE; CYTOKINE; EPHRIN A1; EPIDERMAL GROWTH FACTOR; EPIREGULIN; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 6; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FRIZZLED PROTEIN; FRIZZLED PROTEIN 5; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MIDKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYC PROTEIN; NEUROPILIN 1; NEUROPILIN 2; SCATTER FACTOR; SOMATOMEDIN C; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CORONARY BLOOD VESSEL; DOWN REGULATION; ENDOTHELIUM CELL; FIBROBLAST; GENE CONTROL; GENE DELETION; GENE EXPRESSION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL COMMUNICATION; CELLS, CULTURED; CORONARY VESSELS; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NEOVASCULARIZATION, PHYSIOLOGIC; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYC; RNA; SIGNAL TRANSDUCTION;

EID: 84860217217     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.244590     Document Type: Article

References (42)

1. Patan S. Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling. J Neurooncol. 2000;50:1-15. (Pubitemid 32166287)
2. Risau W, Sariola H, Zerwes HG, Sasse J, Ekblom P, Kemler R, Doetschman T. Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development. 1988;102:471-478. (Pubitemid 18084930)
3. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674. (Pubitemid 27193480)
4. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9:653-660. (Pubitemid 36749213)
5. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001;7:430-436. (Pubitemid 32298545)
6. Friehs I, Margossian RE, Moran AM, Cao-Danh H, Moses MA, del Nido PJ. Vascular endothelial growth factor delays onset of failure in pressure-overload hypertrophy through matrix metalloproteinase activation and angiogenesis. Basic Res Cardiol. 2006;101:204-213.
7. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shumuzu I, Asahara T, Hamada H Tomita S, Molkentin JD, Zou Y, Komuro I. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature. 2007;446:444-448. (Pubitemid 46474597)
8. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest. 2005;115:2108-2118. (Pubitemid 41134152)
9. Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, Davis AC, Ihle JN, Cleveland JL. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002;16:2530-2543.
10. Takeda N, Manabe I. Cellular interplay between cardiomyocytes and nonmyocytes in cardiac remodeling. Int J Inflam. 2011;2011:535241.
11. Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblasts in cancer initiation and progression. Nature. 2004;432:332-337. (Pubitemid 39551661)
12. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005;121:335-348. (Pubitemid 40692295)
13. Newman AC, Naskatsu MN, Chou W, Gershon PD, Hughes CCW. The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Mol Biol Cell. 2011;22:3791-3800.
14. Manabe I, Shindo T, Nagai R. Gene expression in fibroblasts and fibrosis involvement in cardiac hypertrophy. Circ Res. 2002;91:1103-1113. (Pubitemid 36076358)
15. Souders CA, Bowers SLK, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res. 2009;105:1164-1176.
16. Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY. Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest. 2010;120:472-484.
17. Hamik A, Wang B, Jain MK. Transcriptional regulators of angiogenesis. Arterioscler Thromb Vasc Biol. 2006;26:1936-1947. (Pubitemid 44253774)
18. Pandya NM, Dhalla NS, Santani DD. Angiogenesis: a new target for future therapy. Vascul Pharmacol. 2006;44:265-274.
19. Baudino TA, Cleveland JL. The Max Network gone mad. Mol Cell Biol. 2001;21:691-702. (Pubitemid 32104718)
20. He C, Hu H, Braren R, Fong SY, Trumpp A, Carlson TR, Wang RA. c-Myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development. 2008;135:2467-2477.
21. Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leithauser F, Schmidt V, Deutsch U, Wirth T. Myc regulates embryonic vascular permeability and remodeling. Circ Res. 2009;104:1151-1159.
22. Chen Y, Olopade OI. MYC in breast tumor progression. Expert Rev Anticancer Ther. 2008;8:1689-1698.
23. Yekkala K, Baudino TA. Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/1 mice due to decreases in c-Myc expression. Mol Cancer Res. 2007;5:1296-1303.
24. Yazaki Y, Tsuchimochi H, Kurabayashi M, Komuro I. Molecular adaptation to pressure overload in human and rat hearts. J Mol Cell Cardiol. 1989;5:91-101. (Pubitemid 20047553)
25. Xiao G, Mao S, Baumgarten G, Serrano J, Jordan MC, Roos KP, Fishbein MC, MacLellan WR. Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis. Circ Res. 2001;89:1122-1129. (Pubitemid 34627869)
26. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nature Genetics. 2006;38:1060-1065. (Pubitemid 44325933)
27. Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res. 2004;64:6563-6570. (Pubitemid 39297915)
28. de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of c-Myc function in normal cells via conditional gene-targeted mutation. Immunity. 2001;14:45-55. (Pubitemid 32144686)
29. Davis AC, Wims M, Spotts GD, Hann SR, Bradley A. A null c-Myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 1993;7:671-682. (Pubitemid 23125266)
30. Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA. Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci USA. 2006;103:11946-11951. (Pubitemid 44215791)
31. Sohal DS, Nghiem M, Crackower MA, Witt SA Kimball TR, Tymitz KM, Penninger JM, Molkentin JD. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res. 2001;89:20-25. (Pubitemid 34135487)
32. Stratman AN, Davis MJ, Davis GE. VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines. Blood. 2011;117:3709-3719.
33. Banerjee I, Fuseler JW, Souders CA, Bowers SL, Baudino TA. The role of interleukin-6 in the formation of the coronary vasculature. Microsc Microanal. 2009;15:415-21.
34. Glenny RW, Robertson HT, Yamashiro S, Bassingthwaighte JB. Applications of fractal analysis to physiology. J Appl Physiol. 1991;70:2351-2367.
35. Fuseler JW, Merrill DM, Rogers JA, Grisham MB, Wolf RE. Analysis and quantitation of NF-kappaB nuclear translocation in tumor necrosis factor alpha (TNF-alpha) activated vascular endothelial cells. Microsc Microanal. 2006;12:269-276. (Pubitemid 43972853)
36. McKallip RJ, Fisher M, Do Y, Szakal AK, Gunthert U, Nagarkatti PS, Nagarkatti M. Targeted deletion of CD44v7 exon leads to decreased endothelial cell injury but not tumor cell killing mediated by interleukin-2-activated cytolytic lymphocytes. J Biol Chem. 2003;278:43818-30. (Pubitemid 37346010)
37. Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 1998;83:1059-1066. (Pubitemid 28520935)
38. Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang Y, Cho SY, Kim HS. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med. 2001;33:95-102. (Pubitemid 32655888)
39. Martinez-Fernandez A, Nelson TJ, Ikeda Y, Terzic A. c-Myc independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells. J Cardiovac Transl Res. 2010;3:13-23.
40. Liu H, Chen B, Lilly B. Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1. Angiogenesis. 2008;11:223-234.
41. Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood. 2009;114:5091-5101.
42. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest. 2005;115:2059-2064.