Recombinant bone morphogenetic protein-2 induces up-regulation of vascular endothelial growth factor and interleukin 6 in human pre-osteoblasts: Role of reactive oxygen species

Archives of Oral Biology

Volumn 57, Issue 5, 2012, Pages 445-452

  Akeel, Sara ^a,b   El Awady, Ahmed ^a   Hussein, Khaled ^a,c   El Refaey, Mona ^a   Elsalanty, Mohammed ^a   Sharawy, Mohamed ^a   Al Shabrawey, Mohamed ^a,d  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d MANSOURA UNIVERSITY   (Egypt)

Author keywords

IL6; Osteoblasts; rhBMP 2; VEGF

Indexed keywords

BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 2; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A;

ANALYSIS OF VARIANCE; ANGIOGENESIS; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETICS; HUMAN; INFLAMMATION; LIPID PEROXIDATION; METABOLISM; OSTEOBLAST; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; INFLAMMATION; INTERLEUKIN-6; LIPID PEROXIDATION; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOBLASTS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84860215314     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2011.10.002     Document Type: Article

References (35)

1. J. Glowacki Angiogenesis in fracture repair Clin Orthop Relat Res 355 October (Suppl.) 1998 S82 S89
2. U. Mayr-Wohlfart, J. Waltenberger, H. Hausser, S. Kessler, K.P. Gunther, and C. Dehio Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts Bone 30 March (3) 2002 472 477 (Pubitemid 34204121)
3. H. Mayer, H. Bertram, W. Lindenmaier, T. Korff, H. Weber, and H. Weich Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation J Cell Biochem 95 July (4) 2005 827 839 (Pubitemid 41420169)
4. V. Midy, and J. Plouet Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts Biochem Biophys Res Commun 199 February (1) 1994 380 386 (Pubitemid 24179960)
5. B.L. Hogan Bone morphogenetic proteins: multifunctional regulators of vertebrate development Genes Dev 10 July (13) 1996 1580 1594 (Pubitemid 26268864)
6. A. Javed, J.S. Bae, F. Afzal, S. Gutierrez, J. Pratap, and S.K. Zaidi Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal J Biol Chem 283 March (13) 2008 8412 8422
7. T. Imura, K. Tane, N. Toyoda, and S. Fushiki Endothelial cell-derived bone morphogenetic proteins regulate glial differentiation of cortical progenitors Eur J Neurosci 27 April (7) 2008 1596 1606 (Pubitemid 351473577)
8. M. Raida, J.H. Clement, R.D. Leek, K. Ameri, R. Bicknell, and D. Niederwieser Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis J Cancer Res Clin Oncol 131 November (11) 2005 741 750 (Pubitemid 41577951)
9. M.M. Deckers, R.L. van Bezooijen, G. van der Horst, J. Hoogendam, C. van Der Bent, and S.E. Papapoulos Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A Endocrinology 143 April (4) 2002 1545 1553 (Pubitemid 34274386)
10. J. Street, M. Bao, L. deGuzman, S. Bunting, F.V. Peale Jr., and N. Ferrara Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover Proc Natl Acad Sci USA 99 July (15) 2002 9656 9661 (Pubitemid 34831103)
11. H.P. Gerber, T.H. Vu, A.M. Ryan, J. Kowalski, Z. Werb, and N. Ferrara VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation Nat Med 5 June (6) 1999 623 628 (Pubitemid 29289424)
12. M.M. Deckers, M. Karperien, C. van der Bent, T. Yamashita, S.E. Papapoulos, and C.W. Lowik Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation Endocrinology 141 May (5) 2000 1667 1674 (Pubitemid 32274395)
13. G. Bluteau, M. Julien, D. Magne, F. Mallein-Gerin, P. Weiss, and G. Daculsi VEGF and VEGF receptors are differentially expressed in chondrocytes Bone 40 March (3) 2007 568 576 (Pubitemid 46201943)
14. P. Kolar, T. Gaber, C. Perka, G.N. Duda, and Buttgereit F Human early fracture hematoma is characterized by inflammation and hypoxia Clin Orthop Relat Res 469 November (11) 2011 3118 3126
15. S. Dimmen, L. Nordsletten, and J.E. Madsen Parecoxib and indomethacin delay early fracture healing: a study in rats Clin Orthop Relat Res 467 August (8) 2009 1992 1999
16. Y.A. Petrovich, R.P. Podorozhnaya, S.M. Kichenko, and M.V. Kozlova Effects of selenium-containing compounds and their metabolism in intact rats and in animals with bone fractures Bull Exp Biol Med 137 January (1) 2004 74 77 (Pubitemid 39137262)
17. I.R. Garrett, B.F. Boyce, R.O. Oreffo, L. Bonewald, J. Poser, and G.R. Mundy Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo J Clin Invest 85 March (3) 1990 632 639 (Pubitemid 20087462)
18. M.J. Steinbeck, W.H. Appel Jr., A.J. Verhoeven, and M.J. Karnovsky NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone J Cell Biol 126 August (3) 1994 765 772 (Pubitemid 24241388)
19. E. Gokturk, A. Turgut, C. Baycu, I. Gunal, S. Seber, and Z. Gulbas Oxygen-free radicals impair fracture healing in rats Acta Orthop Scand 66 October (5) 1995 473 475
20. M. Al-Shabrawey, M. Bartoli, A.B. El-Remessy, D.H. Platt, S. Matragoon, and M.A. Behzadian Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy Am J Pathol 167 August (2) 2005 599 607 (Pubitemid 43026113)
21. S. Latif, I. Bauer-Sardina, K. Ranade, K.J. Livak, and P.Y. Kwok Fluorescence polarization in homogeneous nucleic acid analysis II: 5′-nuclease assay Genome Res 11 March (3) 2001 436 440 (Pubitemid 32243853)
22. H. Yeler, F. Tahtabas, and F. Candan Investigation of oxidative stress during fracture healing in the rats Cell Biochem Funct 23 March-April (2) 2005 137 139 (Pubitemid 40363686)
23. B.N. Robin, C.D. Chaput, S. Zeitouni, M.D. Rahm, V.A. Zerris, and Sampson HW Cytokine-mediated inflammatory reaction following posterior cervical decompression and fusion associated with recombinant human bone morphogenetic protein-2: a case study Spine (Phila Pa 1976) 35 November (23) 2010 E1350 E1354
24. Y. Wang, C. Wan, S.R. Gilbert, and T.L. Clemens Oxygen sensing and osteogenesis Ann NY Acad Sci 1117 November 2007 1 11 (Pubitemid 350191282)
25. D.E. Komatsu, and M. Hadjiargyrou Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair Bone 34 April (4) 2004 680 688 (Pubitemid 38393804)
26. C. Maes, P. Carmeliet, K. Moermans, I. Stockmans, N. Smets, and D. Collen Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 Mech Dev 111 February (1-2) 2002 61 73 (Pubitemid 34136979)
27. F. Zhang, T. Qiu, X. Wu, C. Wan, W. Shi, and Y. Wang Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation J Bone Miner Res 24 July (7) 2009 1224 1233
28. D.S. Wang, K. Yamazaki, K. Nohtomi, K. Shizume, K. Ohsumi, and M. Shibuya Increase of vascular endothelial growth factor mRNA expression by 1,25-dihydroxyvitamin D3 in human osteoblast-like cells J Bone Miner Res 11 April (4) 1996 472 479
29. J. Garcia-Roman, A. Ibarra-Sanchez, M. Lamas, and C. Gonzalez Espinosa VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells Biochem Biophys Res Commun 401 October (2) 2010 262 267
30. S. Botolin, and L.R. McCabe Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways J Cell Biochem 99 October (2) 2006 411 424 (Pubitemid 44435559)
31. N. Kloting, N. Follak, and I. Kloting Is there an autoimmune process in bone? Gene expression studies in diabetic and nondiabetic BB rats as well as BB rat-related and -unrelated rat strains Physiol Genomics 24 December (1) 2005 59 64
32. A. Csiszar, M. Ahmad, K.E. Smith, N. Labinskyy, Q. Gao, and G. Kaley Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype Am J Pathol 168 February (2) 2006 629 638 (Pubitemid 43271160)
33. C.C. Mandal, S. Ganapathy, Y. Gorin, K. Mahadev, K. Block, and H.E. Abboud Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation Biochem J 433 December (2) 2010 393 402
34. A. Tawfik, T. Sanders, K. Kahook, S. Akeel, A. Elmarakby, and M. Al-Shabrawey Suppression of retinal peroxisome proliferator-activated receptor gamma in experimental diabetes and oxygen-induced retinopathy: role of NADPH oxidase Invest Ophthalmol Vis Sci 50 February (2) 2009 878 884
35. C. Turk, M. Halici, A. Guney, H. Akgun, V. Sahin, and S. Muhtaroglu Promotion of fracture healing by vitamin E in rats J Int Med Res 32 September-October (5) 2004 507 512 (Pubitemid 39255595)