A persistent stress response to impeded axonal transport leads to accumulation of amyloid-β in the endoplasmic reticulum, and is a probable cause of sporadic Alzheimer's disease

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 60-63

  Muresan, Virgil ^a   Muresan, Zoia ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Amyloid precursor protein; Axonal transport; Endoplasmic reticulum stress; Kinesin; Mechanism of neurodegenerative diseases; Protein phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; KINESIN 1; PROTEIN FE65; STRESS ACTIVATED PROTEIN KINASE;

ALZHEIMER DISEASE; CELL NUCLEUS; COMPLEX FORMATION; CYTOPLASM; ENDOPLASMIC RETICULUM; OLIGOMERIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; STRESS; VASCULAR AMYLOIDOSIS;

AMYLOID BETA-PEPTIDES; ANIMALS; AXONAL TRANSPORT; CELL LINE, TRANSFORMED; ENDOPLASMIC RETICULUM; HUMANS; KINESIN; NERVE TISSUE PROTEINS; NEURITES; NEURONS; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; OSMOLAR CONCENTRATION; PROTO-ONCOGENE PROTEINS; STRESS, PHYSIOLOGICAL; TRANSFECTION;

EID: 84860215166     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000332815     Document Type: Review

References (20)

1. Herrup K: Reimagining Alzheimer's disease - An age-based hypothesis. J Neurosci 2010; 30: 16755-16762.
2. Muresan V, Muresan Z: Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? Future Neurol 2009; 4: 761-773.
3. Qi Y, Wang JK, McMillian M, Chikaraishi DM: Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. J Neurosci 1997; 17: 1217-1225.
4. Muresan V, Varvel NH, Lamb BT, Muresan Z: The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. J Neurosci 2009; 29: 3565-3578.
5. Muresan Z, Muresan V: A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. Hum Mol Genet 2004; 13: 475-488.
6. Muresan Z, Muresan V: c-Jun NH2-termi - nal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein. J Neurosci 2005; 25: 3741-3751.
7. Muresan Z, Muresan V: Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase- interacting protein-1. J Cell Biol 2005; 171: 615-625.
8. Muresan Z, Muresan V: Neuritic deposits of amyloid-3β peptide in a subpopulation of central nervous system-derived neuronal cells. Mol Cell Biol 2006; 26: 4982-4997.
9. Muresan Z, Muresan V: The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration. Mol Biol Cell 2007; 18: 3835-3844.
10. Muresan Z, Muresan V: Seeding neuritic plaques from the distance: a possible role for brainstem neurons in the development of Alzheimer's disease pathology. Neurodegener Dis 2008; 5: 250-253.
11. Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR: Intraneuronal abeta42 accumulation in human brain. Am J Pathol 2000; 156: 15-20.
12. Muresan Z, Muresan V: The phosphorylated, carboxy-terminal fragments of amyloid-3β precursor protein are targeted to multiple intraneuronal locations by destination-specific molecular motors and adaptor proteins. Annu Meet Soc Neurosci, Chicago, October 17-21, 2009.
13. Muresan Z, Muresan V: Kinesin-1 is a signaling protein that recruits active kinase complexes and directly participates in substrate phosphorylation. Annu Meet Am Soc Cell Biol, San Francisco, December 13-17, 2008.
14. Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH: APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol 2003; 163: 83-95.
15. Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K: Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65- PTB2. EMBO Rep 2008; 9: 1134-1140.
16. Zhou D, Zambrano N, Russo T, D'Adamio L: Phosphorylation of a tyrosine in the amyloid- beta protein precursor intracellular domain inhibits Fe65 binding and signaling. J Alzheimers Dis 2009; 16: 301-307.
17. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG: Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta- amyloid precursor protein. Cell 2002; 110: 55-67.
18. Cao X, Sudhof TC: A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001; 293: 115-120.
19. He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R: Reticulon family members modulate bace1 activity and amyloid-beta peptide generation. Nat Med 2004; 10: 959-965.
20. 2+leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 2006; 126: 981-993.