Therapeutic effects of inhaled inactivated Mycobacterium phlei in adult patients with moderate persistent asthma

Immunotherapy

Volumn 4, Issue 4, 2012, Pages 383-387

  Zhang, Jinghong ^a   Guo, Sujuan ^a   Li, Chaoqian ^a   Jiang, Xiaohong ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

asthma control test; atomization; bronchial asthma; FEV1; Mycobacterium phlei; PEF

Indexed keywords

ANTIASTHMATIC AGENT; FLUTICASONE PROPIONATE PLUS SALMETEROL; FLUTICASONE PROPIONATE PLUS SALMETEROL XINAFOATE; INACTIVATED MYCOBACTERIUM PHLEI VACCINE; INACTIVATED VACCINE; MYCOBACTERIUM VACCINE; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; MODERATE PERSISTENT ASTHMA; NEBULIZATION; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AGED; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHIAL PROVOCATION TESTS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; MYCOBACTERIUM PHLEI; NEBULIZERS AND VAPORIZERS; PEAK EXPIRATORY FLOW RATE; SPIROMETRY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84860180188     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.12.25     Document Type: Article

References (15)

1. Asher MI. Recent perspectives on global epidemiology of asthma in childhood. Allergol. Immunopathol. (Madr). 38(2), 83-87 (2010).
2. Garn H, Renz H. Epidemiological and immunological evidence for the hygiene hypothesis. Immunobiology 212 (6), 441-452 (2007). (Pubitemid 46825255)
3. Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 275(5296), 77-79 (1997). (Pubitemid 27020311)
4. El-Zein M, Parent ME, Benedetti A, Rousseau MC. Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies. Int. J. Epidemiol. 39(2), 469-486 (2010).
5. Agbetile J, Green R. New therapies and management strategies in the treatment of asthma: patient-focused developments. J. Asthma Allergy 4, 1-12 (2011).
6. Lagranderie M, Nahori MA, Balazuc AM et al. Dendritic cells recruited to the lung shortly after intranasal delivery of Mycobacterium bovis BCG drive the primary immune response towards a type 1 cytokine production. Immunology 108(3), 352-364 (2003). (Pubitemid 36332394)
7. Hopfenspirger MT, Agrawal DK. Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice. J. Immunol. 168, 2516-2522 (2002). (Pubitemid 34171858)
8. Schatz M, Mosen DM, Kosinski M et al. The relationship between asthma-specific quality of life and asthma control. J. Asthma 44(5), 391-395 (2007). (Pubitemid 47026914)
9. Zuany-Amorim C, Sawicka E, Manlius C et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergenspecific regulatory T-cells. Nat. Med. 8, 625-629 (2002). (Pubitemid 34633442)
10. Shen H, Huang H, Wang J et al. Neonatal vaccination with Bacillus Calmette-Guérin elicits long-term protection in mouse-allergic responses. Allergy 63(5), 555-563 (2008). (Pubitemid 351490399)
11. Ozdemir C, Akkoc T, Bahceciler NN, Kucukercan D, Barlan IB, Basaran MM. Impact of Mycobacterium vaccae immunization on lung histopathology in a murine model of chronic asthma. Clin. Exp. Allergy 33(2), 266-270 (2003). (Pubitemid 36241386)
12. Erb KJ, Holloway JW, Sobeck A, Moll H, Le Gros G. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia. J. Exp. Med. 187(4), 561-569 (1998). (Pubitemid 28093358)
13. Wang P, Zhang G, Qin X et al. Inhibition of allergen-induced airway remodeling by neonatal Bacillus Calmette-Guerin vaccination is associated with interferon-gamma-producing T cells but not regulatory T cells in mice. Ann. Allergy Asthma Immunol. 107(2), 163-170 (2011).
14. Christ AP, Rodriguez D, Bortolatto J et al. Enhancement of Th1 lung immunity induced by recombinant Mycobacterium bovis Bacillus Calmette-Guerin attenuates airway allergic disease. Am. J. Respir. Cell Mol. Biol. 43(2), 243-245 (2010).
15. Levine MM, Dougan G. Optimism over vaccines administered via mucosal surfaces. Lancet 351(9113), 1375-1376 (1998). (Pubitemid 28209992)