Emergence of Proteus mirabilis harboring bla KPC-2 and qnrD in a Chinese hospital

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 5, 2012, Pages 2278-2282

  Hu, Yan Yan ^a   Cai, Jia Chang ^a   Zhang, Rong ^a   Zhou, Hong Wei ^a   Sun, Qian ^a   Chen, Gong Xiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMPICILLIN; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; ERTAPENEM; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; SULPERAZON;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLA KPC 2 GENE; CHINA; GENE LOCATION; GENE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEUS MIRABILIS; QNRD GENE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CHINA; CIPROFLOXACIN; CLONE CELLS; CONJUGATION, GENETIC; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; ESCHERICHIA COLI; GENES, BACTERIAL; HUMANS; PLASMIDS; POLYMERASE CHAIN REACTION; PROTEUS INFECTIONS; PROTEUS MIRABILIS; QUINOLONES; SEQUENCE ANALYSIS, DNA;

EID: 84860170991     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05519-11     Document Type: Article

References (22)

1. Cai JC, Zhou HW, Chen GX, Zhang R. 2008. Detection of plasmidmediated carbapenem-hydrolyzing beta-lactamase KPC-2 in a strain of carbapenem-resistant Enterobacter cloacae. Zhonghua Yi Xue Za Zhi 88: 135-138. (In Chinese.) (Pubitemid 351459789)
2. Cai JC, Zhou HW, Zhang R, Chen GX. 2008. Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. Antimicrob. Agents Chemother. 52:2014-2018. (Pubitemid 351758537)
3. Cavaco LM, Hasman H, Xia S, Aarestrup FM. 2009. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob. Agents Chemother. 53:603-608.
4. Clinical and Laboratory Standards Institute. 2011. Performance standards for antimicrobial susceptibility testing; 21th informational supplement. CLSI document M100-S21. Clinical and Laboratory Standards Institute, Wayne, PA.
5. Jiang Y, et al. 2008. Plasmid-mediated quinolone resistance determinants qnr and aac(6′)-Ib-cr in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in China. J. Antimicrob. Chemother. 61:1003-1006. (Pubitemid 351524439)
6. Ma J, et al. 2009. High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofurresistant Enterobacteriaceae isolates from companion and foodproducing animals. Antimicrob. Agents Chemother. 53:519-524.
7. Martinez-Martinez L, Pascual A, Jacoby GA. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797-799. (Pubitemid 28112342)
8. Perez-Perez FJ, Hanson ND. 2002. Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. J. Clin. Microbiol. 40:2153-2162. (Pubitemid 34596400)
9. Robicsek A, et al. 2006. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12:83-88. (Pubitemid 43050081)
10. Sacha P, et al. 2009. The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli. Folia Histochem. Cytobiol. 47:537-543.
11. Seifert H, et al. 2005. Standardization and interlaboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of Acinetobacter baumannii. J. Clin. Microbiol. 43:4328-4335. (Pubitemid 41298209)
12. Shen P, et al. 2009. Novel genetic environment of the carbapenemhydrolyzing beta-lactamase KPC-2 among Enterobacteriaceae in China. Antimicrob. Agents Chemother. 53:4333-4338.
13. Sheng ZK, Li JJ, Sheng GP, Sheng JF, Li LJ. 2010. Emergence of Klebsiella pneumoniae carbapenemase-producing Proteus mirabilis in Hangzhou, China. Chin. Med. J. (Engl.). 123:2568-2570.
14. Tenover FC, et al. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel-electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
15. Tibbetts R, Frye JG, Marschall J, Warren D, Dunne W. 2008. Detection of KPC-2 in a clinical isolate of Proteus mirabilis and first reported description of carbapenemase resistance caused by a KPC beta-lactamase in P. mirabilis. J. Clin. Microbiol. 46:3080-3083.
16. Wang F, et al. 2010. CHINET 2009 surveillance of bacterial resistance in China. Chin. J. Infect. Chemother. 10:325-334. (In Chinese.)
17. Wang MH, et al. 2009. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob. Agents Chemother. 53:1892-1897.
18. Weigel LM, Anderson GJ, Tenover FC. 2002. DNA gyrase and topoisomerase IV mutations associated with fluoroquinolone resistance in Proteus mirabilis. Antimicrob. Agents Chemother. 46:2582-2587. (Pubitemid 34793467)
19. Yigit H, et al. 2001. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 45:1151-1161. (Pubitemid 32230996)
20. Yu YS, et al. 2007. Resistance of strains producing extended-spectrum beta-lactamases and genotype distribution in China. J. Infect. 54:53-57.
21. Zhang R, Yang L, Cai JC, Zhou HW, Chen GX. 2008. High-level carbapenem resistance in a Citrobacter freundii clinical isolate is due to a combination of KPC-2 production and decreased porin expression. J. Med. Microbiol. 57:332-337. (Pubitemid 351358536)
22. Zhang R, Zhou HW, Cai JC, Chen GX. 2007. Plasmid-mediated carbapenem-hydrolysing beta-lactamase KPC-2 in carbapenem-resistant Serratia marcescens isolates from Hangzhou, China. J. Antimicrob. Chemother. 59:574-576. (Pubitemid 47073471)