A practical stereoselective synthesis and novel cocrystallizations of an amphiphatic SGLT-2 inhibitor

Organic Process Research and Development

Volumn 16, Issue 4, 2012, Pages 577-585

  Deshpande, Prashant P ^a   Singh, Janak ^b   Pullockaran, Annie ^b   Kissick, Thomas ^b   Ellsworth, Bruce A ^c   Gougoutas, Jack Z ^e   Dimarco, John ^e   Fakes, Michael ^f,g   Reyes, Mayra ^a   Lai, Chiajen ^a   Lobinger, Hidegard ^d   Denzel, Theo ^d   Ermann, Peter ^d   Crispino, Gerard ^b   Randazzo, Michael ^a   Gao, Zenrong ^a   Randazzo, Renee ^a   Lindrud, Mark ^a   Rosso, Victor ^a   Buono, Frederic ^a   Doubleday, Wendel W ^a   Leung, Simon ^a   Richberg, Pricilla ^e   Hughes, David ^e   Washburn, William N ^c   Meng, Wei ^c   Volk, Kevin J ^a   Mueller, Richard H ^a   more..

^a Chemical Development   (United States)

^b Research and Development   (United States)

^c Metabolic Disease Discovery Chemistry   (United States)

^d Process Research and Development   (Germany)

^e Analytical Research and Development   (United States)

^f Exploratory Biopharmaceutics and Stability   (United States)

^g BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANOMERICS; CHIRAL BUILDING BLOCKS; CHIRAL CENTERS; CO-CRYSTALLIZATIONS; L-PHENYLALANINE; L-PROLINE; SILYL HYDRIDES; SINGLE-CRYSTAL STRUCTURE; STEREOSELECTIVE REDUCTION; STEREOSELECTIVE SYNTHESIS; SYNTHETIC INTERMEDIATES; TRIMETHYLSILYL CHLORIDE;

AMINO ACIDS; CHLORINE COMPOUNDS; STEREOCHEMISTRY; SUGARS;

STEREOSELECTIVITY;

EID: 84860159933     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200306q     Document Type: Article

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