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Volumn 6, Issue 4, 2012, Pages 464-469

Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease

Author keywords

Anti TNF ; Intestinal permeability; Mucosal healing

Indexed keywords

AZATHIOPRINE; INFLIXIMAB; LACTULOSE; MANNITOL; METHOTREXATE; SALAZOSULFAPYRIDINE;

EID: 84860125647     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2011.10.004     Document Type: Article
Times cited : (61)

References (47)
  • 1
    • 77954078769 scopus 로고    scopus 로고
    • Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies
    • Han X. Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies. Recent Pat Inflamm Allergy Drug Discov 2011, 4(2):159-176.
    • (2011) Recent Pat Inflamm Allergy Drug Discov , vol.4 , Issue.2 , pp. 159-176
    • Han, X.1
  • 2
    • 21844465744 scopus 로고    scopus 로고
    • Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent
    • Suenaert P., Bulteel V., Vermeire S., Noman M., Van Assche G., Rutgeerts P. Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent. Inflamm Bowel Dis 2005, 11(7):667-673.
    • (2005) Inflamm Bowel Dis , vol.11 , Issue.7 , pp. 667-673
    • Suenaert, P.1    Bulteel, V.2    Vermeire, S.3    Noman, M.4    Van Assche, G.5    Rutgeerts, P.6
  • 3
    • 0036678630 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
    • Suenaert P., Bulteel V., Lemmens L., Noman M., Geypens B., Van Assche G., et al. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol 2002, 97(8):2000-2004.
    • (2002) Am J Gastroenterol , vol.97 , Issue.8 , pp. 2000-2004
    • Suenaert, P.1    Bulteel, V.2    Lemmens, L.3    Noman, M.4    Geypens, B.5    Van Assche, G.6
  • 4
    • 4344700784 scopus 로고    scopus 로고
    • Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment
    • Zeissig S., Bojarski C., Buergel N., Mankertz J., Zeitz M., Fromm M., et al. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 2004, 53(9):1295-1302.
    • (2004) Gut , vol.53 , Issue.9 , pp. 1295-1302
    • Zeissig, S.1    Bojarski, C.2    Buergel, N.3    Mankertz, J.4    Zeitz, M.5    Fromm, M.6
  • 5
    • 9344264671 scopus 로고    scopus 로고
    • Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha
    • Soderholm J.D., Streutker C., Yang P.C., Paterson C., Singh P.K., McKay D.M., et al. Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha. Gut 2004, 53(12):1817-1824.
    • (2004) Gut , vol.53 , Issue.12 , pp. 1817-1824
    • Soderholm, J.D.1    Streutker, C.2    Yang, P.C.3    Paterson, C.4    Singh, P.K.5    McKay, D.M.6
  • 6
    • 33644827003 scopus 로고    scopus 로고
    • Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy
    • Fries W., Renda M.C., Lo Presti M.A., Raso A., Orlando A., Oliva L., et al. Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy. Am J Gastroenterol 2005, 100(12):2730-2736.
    • (2005) Am J Gastroenterol , vol.100 , Issue.12 , pp. 2730-2736
    • Fries, W.1    Renda, M.C.2    Lo Presti, M.A.3    Raso, A.4    Orlando, A.5    Oliva, L.6
  • 7
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?
    • Buhner S., Buning C., Genschel J., Kling K., Herrmann D., Dignass A., et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?. Gut 2006, 55(3):342-347.
    • (2006) Gut , vol.55 , Issue.3 , pp. 342-347
    • Buhner, S.1    Buning, C.2    Genschel, J.3    Kling, K.4    Herrmann, D.5    Dignass, A.6
  • 8
    • 0033003669 scopus 로고    scopus 로고
    • Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?
    • Soderholm J.D., Olaison G., Lindberg E., Hannestad U., Vindels A., Tysk C., et al. Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?. Gut 1999, 44(1):96-100.
    • (1999) Gut , vol.44 , Issue.1 , pp. 96-100
    • Soderholm, J.D.1    Olaison, G.2    Lindberg, E.3    Hannestad, U.4    Vindels, A.5    Tysk, C.6
  • 9
    • 33646246756 scopus 로고    scopus 로고
    • Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease
    • D'Inca R., Annese V., di Leo V., Latiano A., Quaino V., Abazia C., et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease. Aliment Pharmacol Ther 2006, 23(10):1455-1461.
    • (2006) Aliment Pharmacol Ther , vol.23 , Issue.10 , pp. 1455-1461
    • D'Inca, R.1    Annese, V.2    di Leo, V.3    Latiano, A.4    Quaino, V.5    Abazia, C.6
  • 10
    • 34249945094 scopus 로고    scopus 로고
    • Defensins and other antimicrobial peptides in inflammatory bowel disease
    • Wehkamp J., Schmid M., Stange E.F. Defensins and other antimicrobial peptides in inflammatory bowel disease. Curr Opin Gastroenterol 2007, 23(4):370-378.
    • (2007) Curr Opin Gastroenterol , vol.23 , Issue.4 , pp. 370-378
    • Wehkamp, J.1    Schmid, M.2    Stange, E.F.3
  • 11
    • 43049174584 scopus 로고    scopus 로고
    • NOD-like receptors: ancient sentinels of the innate immune system
    • Rosenstiel P., Jacobs G., Till A., Schreiber S. NOD-like receptors: ancient sentinels of the innate immune system. Cell Mol Life Sci 2008, 65(9):1361-1377.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.9 , pp. 1361-1377
    • Rosenstiel, P.1    Jacobs, G.2    Till, A.3    Schreiber, S.4
  • 12
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor R.B. Microbial influences in inflammatory bowel diseases. Gastroenterology 2008, 134(2):577-594.
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 577-594
    • Sartor, R.B.1
  • 14
    • 0038235701 scopus 로고    scopus 로고
    • Review article: the expanding role of biological agents in the treatment of inflammatory bowel disease-focus on selective adhesion molecule inhibition
    • Rutgeerts P., Van Deventer S., Schreiber S. Review article: the expanding role of biological agents in the treatment of inflammatory bowel disease-focus on selective adhesion molecule inhibition. Aliment Pharmacol Ther 2003, 17(12):1435-1450.
    • (2003) Aliment Pharmacol Ther , vol.17 , Issue.12 , pp. 1435-1450
    • Rutgeerts, P.1    Van Deventer, S.2    Schreiber, S.3
  • 16
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
    • Irvine E.J., Marshall J.K. Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 2000, 119(6):1740-1744.
    • (2000) Gastroenterology , vol.119 , Issue.6 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2
  • 17
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohn's disease
    • Wyatt J., Vogelsang H., Hubl W., Waldhoer T., Lochs H. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 1993, 341(8858):1437-1439.
    • (1993) Lancet , vol.341 , Issue.8858 , pp. 1437-1439
    • Wyatt, J.1    Vogelsang, H.2    Hubl, W.3    Waldhoer, T.4    Lochs, H.5
  • 18
    • 0030036718 scopus 로고    scopus 로고
    • Enhanced absorption of macromolecules. A secondary factor in Crohn's disease
    • Malin M., Isolauri E., Pikkarainen P., Karikoski R., Isolauri J. Enhanced absorption of macromolecules. A secondary factor in Crohn's disease. Dig Dis Sci 1996, 41(7):1423-1428.
    • (1996) Dig Dis Sci , vol.41 , Issue.7 , pp. 1423-1428
    • Malin, M.1    Isolauri, E.2    Pikkarainen, P.3    Karikoski, R.4    Isolauri, J.5
  • 19
    • 0033635128 scopus 로고    scopus 로고
    • Abnormal intestinal permeability predicts relapse in inactive Crohn disease
    • Arnott I.D., Kingstone K., Ghosh S. Abnormal intestinal permeability predicts relapse in inactive Crohn disease. Scand J Gastroenterol 2000, 35(11):1163-1169.
    • (2000) Scand J Gastroenterol , vol.35 , Issue.11 , pp. 1163-1169
    • Arnott, I.D.1    Kingstone, K.2    Ghosh, S.3
  • 20
    • 0032871326 scopus 로고    scopus 로고
    • Intestinal permeability test as a predictor of clinical course in Crohn's disease
    • D'Inca R., Di Leo V., Corrao G., Martines D., D'Odorico A., Mestriner C., et al. Intestinal permeability test as a predictor of clinical course in Crohn's disease. Am J Gastroenterol 1999, 94(10):2956-2960.
    • (1999) Am J Gastroenterol , vol.94 , Issue.10 , pp. 2956-2960
    • D'Inca, R.1    Di Leo, V.2    Corrao, G.3    Martines, D.4    D'Odorico, A.5    Mestriner, C.6
  • 23
    • 0021249452 scopus 로고
    • In vitro determination of small intestinal permeability: demonstration of a persistent defect in patients with coeliac disease
    • Bjarnason I., Peters T.J. In vitro determination of small intestinal permeability: demonstration of a persistent defect in patients with coeliac disease. Gut 1984, 25(2):145-150.
    • (1984) Gut , vol.25 , Issue.2 , pp. 145-150
    • Bjarnason, I.1    Peters, T.J.2
  • 24
    • 0028182407 scopus 로고
    • Technetium (99mTc)-labelled white cell scanning, 51Cr-EDTA and 14C-mannitol-labelled intestinal permeability studies: non-invasive methods of diagnosing acute intestinal graft-versus-host disease
    • Mahendra P., Bedlow A.J., Ager S., Ancliff P.J., Wraight E.P., Marcus R.E. Technetium (99mTc)-labelled white cell scanning, 51Cr-EDTA and 14C-mannitol-labelled intestinal permeability studies: non-invasive methods of diagnosing acute intestinal graft-versus-host disease. Bone Marrow Transplant 1994, 13(6):835-837.
    • (1994) Bone Marrow Transplant , vol.13 , Issue.6 , pp. 835-837
    • Mahendra, P.1    Bedlow, A.J.2    Ager, S.3    Ancliff, P.J.4    Wraight, E.P.5    Marcus, R.E.6
  • 25
    • 0023510047 scopus 로고
    • Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate
    • Andre C., Andre F., Colin L., Cavagna S. Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate. Ann Allergy 1987, 59(5 Pt 2):127-130.
    • (1987) Ann Allergy , vol.59 , Issue.5 PART. 2 , pp. 127-130
    • Andre, C.1    Andre, F.2    Colin, L.3    Cavagna, S.4
  • 26
    • 0020643629 scopus 로고
    • Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon
    • Ukabam S.O., Clamp J.R., Cooper B.T. Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon. Digestion 1983, 27(2):70-74.
    • (1983) Digestion , vol.27 , Issue.2 , pp. 70-74
    • Ukabam, S.O.1    Clamp, J.R.2    Cooper, B.T.3
  • 27
    • 0020393263 scopus 로고
    • Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man
    • Laker M.F., Bull H.J., Menzies I.S. Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man. Eur J Clin Invest 1982, 12(6):485-491.
    • (1982) Eur J Clin Invest , vol.12 , Issue.6 , pp. 485-491
    • Laker, M.F.1    Bull, H.J.2    Menzies, I.S.3
  • 28
    • 0021325778 scopus 로고
    • Intestinal permeability in the newborn
    • Weaver L.T., Laker M.F., Nelson R. Intestinal permeability in the newborn. Arch Dis Child 1984, 59(3):236-241.
    • (1984) Arch Dis Child , vol.59 , Issue.3 , pp. 236-241
    • Weaver, L.T.1    Laker, M.F.2    Nelson, R.3
  • 30
    • 0034038566 scopus 로고    scopus 로고
    • Intestinal permeability is increased in patients with intermittent claudication
    • Iwata H., Matsushita M., Nishikimi N., Sakurai T., Nimura Y. Intestinal permeability is increased in patients with intermittent claudication. J Vasc Surg 2000, 31(5):1003-1007.
    • (2000) J Vasc Surg , vol.31 , Issue.5 , pp. 1003-1007
    • Iwata, H.1    Matsushita, M.2    Nishikimi, N.3    Sakurai, T.4    Nimura, Y.5
  • 31
    • 47849124070 scopus 로고    scopus 로고
    • Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome
    • Goebel A., Buhner S., Schedel R., Lochs H., Sprotte G. Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Rheumatology (Oxford) 2008, 47(8):1223-1227.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.8 , pp. 1223-1227
    • Goebel, A.1    Buhner, S.2    Schedel, R.3    Lochs, H.4    Sprotte, G.5
  • 32
    • 0001677717 scopus 로고
    • A practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. A practical and powerful approach to multiple testing. J R Stat Soc B Methodol 1995, 57:289-300.
    • (1995) J R Stat Soc B Methodol , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 34
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells
    • Nusrat A., Turner J.R., Madara J.L. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 2000, 279(5):G851-G857.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279 , Issue.5
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 35
    • 67249085206 scopus 로고    scopus 로고
    • Tight junctions: molecular structure meets function
    • Schulzke J.D., Fromm M. Tight junctions: molecular structure meets function. Ann N Y Acad Sci 2009, 1165:1-6.
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 1-6
    • Schulzke, J.D.1    Fromm, M.2
  • 36
    • 79953174256 scopus 로고    scopus 로고
    • The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    • Marchiando A.M., Shen L., Graham W.V., Edelblum K.L., Duckworth C.A., Guan Y., et al. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 2011.
    • (2011) Gastroenterology
    • Marchiando, A.M.1    Shen, L.2    Graham, W.V.3    Edelblum, K.L.4    Duckworth, C.A.5    Guan, Y.6
  • 37
    • 70449505391 scopus 로고    scopus 로고
    • Therapeutic options to modulate barrier defects in inflammatory bowel disease
    • Hering N.A., Schulzke J.D. Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig Dis 2009, 27(4):450-454.
    • (2009) Dig Dis , vol.27 , Issue.4 , pp. 450-454
    • Hering, N.A.1    Schulzke, J.D.2
  • 38
    • 9344257937 scopus 로고    scopus 로고
    • Increased gut permeability in Crohn's disease: is TNF the link?
    • Gibson P.R. Increased gut permeability in Crohn's disease: is TNF the link?. Gut 2004, 53(12):1724-1725.
    • (2004) Gut , vol.53 , Issue.12 , pp. 1724-1725
    • Gibson, P.R.1
  • 39
    • 0036677473 scopus 로고    scopus 로고
    • Crohn's disease, TNF-alpha, and the leaky gut. The chicken or the egg?
    • Hollander D. Crohn's disease, TNF-alpha, and the leaky gut. The chicken or the egg?. Am J Gastroenterol 2002, 97(8):1867-1868.
    • (2002) Am J Gastroenterol , vol.97 , Issue.8 , pp. 1867-1868
    • Hollander, D.1
  • 40
    • 62749111325 scopus 로고    scopus 로고
    • Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects
    • Vilela E.G., Torres H.O., Ferrari M.L., Lima A.S., Cunha A.S. Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects. Braz J Med Biol Res 2008, 41(12):1105-1109.
    • (2008) Braz J Med Biol Res , vol.41 , Issue.12 , pp. 1105-1109
    • Vilela, E.G.1    Torres, H.O.2    Ferrari, M.L.3    Lima, A.S.4    Cunha, A.S.5
  • 41
    • 0030777331 scopus 로고    scopus 로고
    • Increased gastric and intestinal permeability in patients with Crohn's disease
    • Wyatt J., Oberhuber G., Pongratz S., Puspok A., Moser G., Novacek G., et al. Increased gastric and intestinal permeability in patients with Crohn's disease. Am J Gastroenterol 1997, 92(10):1891-1896.
    • (1997) Am J Gastroenterol , vol.92 , Issue.10 , pp. 1891-1896
    • Wyatt, J.1    Oberhuber, G.2    Pongratz, S.3    Puspok, A.4    Moser, G.5    Novacek, G.6
  • 42
    • 42049114849 scopus 로고    scopus 로고
    • Dynamics of enterocyte tight junctions: effect of experimental colitis and two different anti-TNF strategies
    • Fries W., Muja C., Crisafulli C., Cuzzocrea S., Mazzon E. Dynamics of enterocyte tight junctions: effect of experimental colitis and two different anti-TNF strategies. Am J Physiol 2008, 294(4):G938-G947.
    • (2008) Am J Physiol , vol.294 , Issue.4
    • Fries, W.1    Muja, C.2    Crisafulli, C.3    Cuzzocrea, S.4    Mazzon, E.5
  • 44
    • 44349127287 scopus 로고    scopus 로고
    • Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab
    • Di Sabatino A., Rosado M.M., Cazzola P., Biancheri P., Tinozzi F.P., Laera M.R., et al. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab. Inflamm Bowel Dis 2008, 14(5):591-596.
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.5 , pp. 591-596
    • Di Sabatino, A.1    Rosado, M.M.2    Cazzola, P.3    Biancheri, P.4    Tinozzi, F.P.5    Laera, M.R.6
  • 45
    • 70249118593 scopus 로고    scopus 로고
    • Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus
    • Bourreille A., Ignjatovic A., Aabakken L., Loftus E.V., Eliakim R., Pennazio M., et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Endoscopy 2009, 41(7):618-637.
    • (2009) Endoscopy , vol.41 , Issue.7 , pp. 618-637
    • Bourreille, A.1    Ignjatovic, A.2    Aabakken, L.3    Loftus, E.V.4    Eliakim, R.5    Pennazio, M.6
  • 46
    • 77953229128 scopus 로고    scopus 로고
    • Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn's disease: a meta-analysis
    • [quiz 1249]
    • Dionisio P.M., Gurudu S.R., Leighton J.A., Leontiadis G.I., Fleischer D.E., Hara A.K., et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn's disease: a meta-analysis. Am J Gastroenterol 2011, 105(6):1240-1248. [quiz 1249].
    • (2011) Am J Gastroenterol , vol.105 , Issue.6 , pp. 1240-1248
    • Dionisio, P.M.1    Gurudu, S.R.2    Leighton, J.A.3    Leontiadis, G.I.4    Fleischer, D.E.5    Hara, A.K.6
  • 47
    • 77954078769 scopus 로고    scopus 로고
    • Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies
    • Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies. Recent patents on inflammation & allergy drug discovery;4(2):159-76.
    • Recent patents on inflammation & allergy drug discovery , vol.4 , Issue.2 , pp. 159-76


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