Adjuvant chemoradiation with 5-fluorouracil or capecitabine in patients with gastric cancer after D2 nodal dissection

Anticancer Research

Volumn 32, Issue 4, 2012, Pages 1397-1402

  Osti, Mattia Falchetto ^a   Agolli, Linda ^a   Bracci, Stefano ^a   Monaco, Flavia ^a   Tubin, Slavisa ^a   Minniti, Giuseppe ^a   De Sanctis, Vitaliana ^a   Enrici, Riccardo Maurizi ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

5 fluorouracil; Capecitabine; Combined treatment; D2 node resection; Gastric cancer; Radiotherapy; Regional control

Indexed keywords

CAPECITABINE; FLUOROURACIL;

ABDOMINAL DISCOMFORT; ADJUVANT CHEMORADIOTHERAPY; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER RELAPSE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; DIARRHEA; DISEASE FREE SURVIVAL; DYSPHAGIA; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; SIDE EFFECT; STOMACH CANCER; WEIGHT REDUCTION;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; HUMANS; LYMPH NODE EXCISION; MALE; MIDDLE AGED; RADIOTHERAPY, ADJUVANT; STOMACH NEOPLASMS;

EID: 84860006913     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Parkin DM, Pisani P and Ferlay J: Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80: 827-841, 1999. (Pubitemid 29108856)
2. Yao JC, Mansfield PF, Pisters PW, Feig BW, Janjan NA, Crane C and Ajani JA: Combined-modality therapy for gastric cancer. Semin Surg Oncol 21: 223-227, 2003. (Pubitemid 37521719)
3. Gunderson LL: Gastric cancer - patterns of relapse after surgical resection. Semin Radiat Oncol 12: 150-161, 2002.
4. Gunderson LL, Callister MD, Jaroszewski DE, Ross HJ, Borad MJ, Gray RJ, Lanza LA, Harold KL, Pockaj BA and Trastek VF: Localized gastric or gastroesophageal cancer - chemoradiation is a pertinent component of adjuvant treatment for patients at high risk of relapse. Gastrointest Cancer Res 3: S26-32, 2009.
5. Moertel CG, Childs DS Jr, Reitemeier RJ, Colby MY Jr. and Holbrook MA: Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2: 865-867, 1969.
6. Moertel CG, Childs DS, O'Fallon JR, Holbrook MA, Schutt AJ and Reitemeier RJ: Combined 5-fluoruracil and radiation therapy as a surgical adjuvant for poor prognosis gastric carcinoma. J Clin Oncol 2: 1249-1254, 1984. (Pubitemid 15202699)
7. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM and Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 345: 725-730, 2001.
8. Hallissey MT, Dunn JA, Ward LC and Allum WH: The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. Lancet 343: 1309-1312, 1994.
9. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S and Chua YJ: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 355: 11-20, 2006.
10. Cox JD, Stetz J and Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31: 1341-1346, 1995.
11. National Comprehensive Cancer Network. Clinical practice guidelines in oncology: Gastric cancer, Version 2, 2011. [http://www.nccn.org/professionals/ physician-gls/pdf/gastric.pdf]
12. Earle CC and Maroun JA: Adjuvant chemotherapy after curative resection for gastric cancer in non-Asians patients: revisiting a meta-analysis of randomised trials. Eur J Cancer 35: 1059-1064, 1999. (Pubitemid 29339187)
13. Janunger KG, Hafstrom L and Glimelius B: Chemotherapy in gastric cancer: a review and updated meta-analysis. Eur J Surg 168: 597-608, 2002. (Pubitemid 36355892)
14. Valentini V, Cellini F, Minsky BD, Mattiucci GC, Balducci M, D'Agostino G, D'Angelo E, Dinapoli N, Nicolotti N, Valentini C and La Torre G: Survival after radiotherapy in gastric cancer: systematic review and meta-analysis. Radiother Oncol 92: 176-183, 2009.
15. Kim S, Lim DH, Lee J, Kang WK, MacDonald JS, Park CH, Park SH, Lee SH, Kim K, Park JO, Kim WS, Jung CW, Park YS, Im YH, Sohn TS, Noh JH, Heo JS, Kim YI, Park CK and Park K: An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys 63: 1279-1285, 2005. (Pubitemid 41628018)
16. Moehler M, Lyros O, Gockel I, Galle PR and Lang H: Multidisciplinary management of gastric and gastroesophageal cancers. World J Gastroenterol 14: 3773-3780, 2008.
17. Degiuli M, Sasako M, Calgaro M, Garino M, Rebecchi F, Mineccia M, Scaglione D, Andreone D, Ponti A and Calvo F: Morbidity and mortality after D1 and D2 gastrectomy for cancer: interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomized surgical trial. Eur J Surg Oncol 30: 303-308, 2004. (Pubitemid 38425649)
18. Aftimos PG, Nasr EA, Nasr DI, Noun RJ, Nasr FL, Ghosn MG, El Helou JA and Chahine GY: Adjuvant chemoradiation for gastric adenocarcinoma: an institutional experience. Radiât Oncol 5: 50, 2010.
19. Leong CN, Chung HT, Lee KM, Shakespeare TP, Mukherjee RK, Wong LC, Lu JJ, Tey J, Lim R, So JB and Back MF: Outcomes of adjuvant chemoradiotherapy after a radical gastrectomy and a D2 node dissection for gastric adenocarcinoma. Cancer J 14: 269-275, 2008.
20. Spych M, Serbiak B, Rychter A, Jesien-Lewandowicz E, Gottwald L and Fijuth J: Post-operative radiochemotherapy in patients with gastric cancer: one department's experience of 56 patients. Br J Radiol 84: 457-463, 2011.
21. Kassam Z, Lockwood G, O'brien C, Brierley J, Swallow C, Oza A, Siu L, Knox JJ, Wong R, Cummings B, Kim J, Moore M and Ringash J: Conformai radiotherapy in the adjuvant treatment of the gastric cancer: review of 82 cases. Int J Radiat Oncol Biol Phys 65: 713-719, 2006.
22. Chang ATY, Ng WT, Law AL, Ku KM, Lee MC and Lee AW: Adjuvant chemoradiation for resected gastric cancer: a 10-year experience. Gastric Cancer 14: 63-71, 2011.
23. Orditura M, De Vita F, Muto P, Vitiello F, Murino P, Lieto E, Vecchione L, Romano A, Martinelli E, Renda A, Ferraraccio F, Del Genio A, Ciardiello F and Galizia G: Adjuvant chemoradiotherapy in patients with stage III or IV radically resected gastric cancer. Arch Surg 145: 233-238, 2010.
24. Quero L, Bouchbika Z, Kouto H, Baruch-Hennequin V, Gornet JM, Munoz N, Cojean-Zelek I, Houdart R, Panis Y, Valleur P, Aparicio T, Maylin C and Hennequin C: Postoperative chemotherapy followed by conformal chemoradiotherapy in high-risk gastric cancer. Int J Radiat Oncol Biol Phys, 2011.
25. Leong T, Joon DL, Willis D, Jayamoham J, Spry N, Harvey J, Di Iulio J, Milner A, Mann GB and Michael M: Adjuvant chemoradiation for gastric cancer using epirubicin, cisplatin and 5-fluorouracil before and after three-dimensional conformal radiotherapy with concurrent infusional 5-fluorouracil: A multicenter study of the Tans-Tasman Radiation Oncology Group. Int J Radiat Oncol Biol Phys 79: 690-695, 2011.
26. Lee J, Lim DH, Kim S, Park SH, Park JO, Park YS, Lim HY, Choi MG, Sohn TS, Noh JH, Bae JM, Ahn YC, Sohn I, Jung SH, Park CK, Kim KM and Kanget WK: Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial. J Clin Oncol 30: 268-273, 2012.
27. Dikken JL, van Sandick JW, Maurits Swellengrebel HA, Lind PA, Putter H, Jansen EP, Boot H, van Grieken NC, van de Velde CJ, Verheij M and Cats A: Neo-adjuvant chemotherapy followed by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS). BMC Cancer 11: 329, 2011.