PPF microsphere depot sustains NSAID blood levels with infusion-like kinetics without 'burst'

Journal of Veterinary Pharmacology and Therapeutics

Volumn 35, Issue 3, 2012, Pages 231-238

  Shang, Q ^a,b   Wang, X ^a   Apley, M ^c   Kukanich, S B ^c   Berkland, C ^a,d  

^a UNIVERSITY OF KANSAS   (United States)

^b HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c KANSAS STATE UNIVERSITY   (United States)

^d University of Kansas   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELOXICAM; MICROSPHERE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DOG; DRUG BLOOD LEVEL; ENCAPSULATION; FEMALE; MALE; NONHUMAN; PHARMACEUTICAL ENGINEERING; PRECISION PARTICLE FABRICATION TECHNOLOGY; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DELAYED-ACTION PREPARATIONS; DOGS; FEMALE; INJECTIONS, SUBCUTANEOUS; MALE; MICROSPHERES; THIAZINES; THIAZOLES;

ANIMALIA;

EID: 84860006056     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2011.01317.x     Document Type: Article

References (24)

1. Berkland, C., Kim, K. & Pack, D.W. (2001) Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. Journal of Controlled Release, 73, 59-74.
2. Berkland, C., King, M., Cox, A., Kim, K. & Pack, D. (2002) Precise control of PLG microsphere size provides enhanced control of drug release rate. Journal of Controlled Release, 82, 137-147.
3. Berkland, C., Pollauf, E., Raman, C., Silverman, R., Kim, K. & Pack, D.W. (2007a) Macromolecule release from monodisperse PLG microspheres: control of release rates and investigation of release mechanism. Journal of Pharmaceutical Sciences, 96, 1176-1191.
4. Berkland, C., Pollauf, E., Varde, N., Pack, D.W. & Kim, K.K. (2007b) Monodisperse liquid-filled biodegradable microcapsules. Pharmaceutical Research, 24, 1007-1013.
5. Determan, A.S., Trewyn, B.G., Lin, S.Y., Hamilton, M.N. & Narasimhan, B. (2004) Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres. Journal of Controlled Release, 100, 97-109.
6. Degner, F., Sigmund, R. & Zeidler, H. (2000) Efficacy and tolerability of meloxicam in an observational, controlled cohort study in patients with rheumatic disease. Clinical Therapeutics, 22, 400-410.
7. Engelhardt, G., Homma, D., Schlegel, K., Utzmann, R. & Schnitzler, C. (1995) Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance. Inflammation Research, 44, 423-433.
8. Galer, B.S., Rowbotham, M., Perander, J., Devers, A. & Friedman, E. (2000) Topical diclofenac patch relieves minor sports injury pain results of a multicenter controlled clinical trial. Journal of Pain and Symptom Management, 19, 287-294.
9. Grahame, R. (1995) Transdermal non-steroidal anti-inflammatory agents. The British Journal of Clinical Practice, 49, 33.
10. Gupta, S.K., Bansal, P., Bhardwaj, R.K., Jaiswal, J. & Velpandian, T. (2000) Comparison of analgesic and anti-inflammatory activity of meloxicam gel with diclofenac and piroxicam gels in animal models: pharmacokinetic parameters after topical application. Skin Pharmacology, 15, 105-111.
11. Heyneman, C.A., Lawless-Liday, C. & Wall, G.C. (2000) Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs, 60, 555-574.
12. Jantharaprapap, R. & Stagni, G. (2007) Effects of penetration enhancers on in vitro permeability of meloxicam gels. International Journal of Pharmaceutics, 343, 26-33.
13. Johnson, O.F.L., Ganmukhi, M.M., Bernstein, H., Auer, H. & Khan, M.A. (2002) Composition for sustained release of human growth hormone. Google Patents.
14. Larsen, S.W., Ostergaard, J., Friberg-Johansen, H., Jessen, M.N. & Larsen, C. (2006) In vitro assessment of drug release rates from oil depot formulations intended for intra-articular administration. European Federation for Pharmaceutical Sciences, 29, 348-354.
15. Lipscomb, G.R., Wallis, N., Armstrong, G. & Rees, W.D.W. (1998) Gastrointestinal tolerability of meloxicam and piroxicam: a double-blind placebo-controlled study. British Journal of Clinical Pharmacology, 46, 133.
16. Liu, K.S., Kao, C.H., Liu, S.Y., Sung, K.C., Kuei, C.H. & Wang, J.J. (2006) Novel depots of buprenorphine have a long-acting effect for the management of physical dependence to morphine. Journal of Pharmacy and Pharmacology, 58, 337-344.
17. Martens, M. (1997) Efficacy and tolerability of a topical NSAID patch (local action transcutaneous flurbiprofen) and oral diclofenac in the treatment of soft-tissue rheumatism. Clinical Rheumatology, 16, 25-31.
18. Okada, H., Ogawa, Y. & Yashiki, T. (1987) Prolonged release microcapsules and their production. Google Patents.
19. O'Neil, M.J. (2006) The Merck Index, 14th edn. Merck & Co. Inc., Whitehouse Station, NJ, p. 3465.
20. Orsolini, P., Mauvernay, R.Y. & Deghenghi, R. (1998) Sustained and controlled release of water insoluble polypeptides. Google Patents.
21. Stei, P., Kruss, B., Wiegleb, J. & Trach, V. (1996) Local tissue tolerability of meloxicam, a new NSAID: Indications for parenteral, dermal and mucosal administration. Rheumatology, 35, 44-50.
22. Vaughn, W.M., Van Hamont, J.E. & Setterstrom, J.A. (2003) Sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres. Google Patents.
23. Yuan, Y., Mo, F.K. & Zhong, D.F. (2006) Investigation of microemulsion system for transdermal delivery of meloxicam. International journal of pharmaceutics, 321, 117-123.
24. Yuan, Y., Chen, X. & Zhong, D. (2007) Determination of meloxicam in human plasma by liquid chromatography-tandem mass spectrometry following transdermal administration. Journal of chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 852, 650-654.