-
1
-
-
70349562920
-
Molecular and cellular mechanisms of CLL: Novel therapeutic approaches
-
Pleyer L, Egle A, Hartmann TN, et al. Molecular and cellular mechanisms of CLL: novel therapeutic approaches. Nat Rev Clin Oncol 2009;6:405-418.
-
(2009)
Nat. Rev. Clin. Oncol.
, vol.6
, pp. 405-418
-
-
Pleyer, L.1
Egle, A.2
Hartmann, T.N.3
-
2
-
-
0042971643
-
B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor
-
DOI 10.1146/annurev.immunol.21.120601.141018
-
Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Ann Rev Immunol 2003;21:841-894. (Pubitemid 37174549)
-
(2003)
Annual Review of Immunology
, vol.21
, pp. 841-894
-
-
Chiorazzi, N.1
Ferrarini, M.2
-
3
-
-
0033567907
-
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-1854. (Pubitemid 29430400)
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
4
-
-
4143105617
-
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
-
DOI 10.1056/NEJMoa040857
-
Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004;351:893-901. (Pubitemid 39096916)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.9
, pp. 893-901
-
-
Rassenti, L.Z.1
Huynh, L.2
Toy, T.L.3
Chen, L.4
Keating, M.J.5
Gribben, J.G.6
Neuberg, D.S.7
Flinn, I.W.8
Rai, K.R.9
Byrd, J.C.10
Kay, N.E.11
Greaves, A.12
Weiss, A.13
Kipps, T.J.14
-
5
-
-
0035803371
-
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
-
DOI 10.1084/jem.194.11.1639
-
Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001;194:1639-1647. (Pubitemid 33126814)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.11
, pp. 1639-1647
-
-
Rosenwald, A.1
Alizadeh, A.A.2
Widhopf, G.3
Simon, R.4
Davis, R.E.5
Yu, X.6
Yang, L.7
Pickeral, O.K.8
Rassenti, L.Z.9
Powell, J.10
Botstein, D.11
Byrd, J.C.12
Grever, M.R.13
Cheson, B.D.14
Chiorazzi, N.15
Wilson, W.H.16
Kipps, T.J.17
Brown, P.O.18
Staudt, L.M.19
-
6
-
-
0036624881
-
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
-
DOI 10.1182/blood.V99.11.4087
-
Damle RN, Ghiotto F, Valetto A, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 2002;99:4087-4093. (Pubitemid 35332051)
-
(2002)
Blood
, vol.99
, Issue.11
, pp. 4087-4093
-
-
Damle, R.N.1
Ghiotto, F.2
Valetto, A.3
Albesiano, E.4
Fais, F.5
Yan, X.-J.6
Sison, C.P.7
Allen, S.L.8
Kolitz, J.9
Schulman, P.10
Vinciguerra, V.P.11
Budde, P.12
Frey, J.13
Rai, K.R.14
Ferrarini, M.15
Chiorazzi, N.16
-
7
-
-
33645310982
-
ITAM-mediated tonic signalling through pre-BCR and BCR complexes
-
Monroe JG. ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat Rev Immunol 2002;6:283-294.
-
(2002)
Nat. Rev. Immunol.
, vol.6
, pp. 283-294
-
-
Monroe, J.G.1
-
8
-
-
64849113027
-
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia cells
-
, Laurenti L, Longo PG, et al. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia cells. Leukemia 2009;23:686-693.
-
(2009)
Leukemia
, vol.23
, pp. 686-693
-
-
Laurenti, L.1
Longo, P.G.2
-
9
-
-
20144385604
-
Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
-
DOI 10.1172/JCI200522094
-
Contri A, Brunati AM, Trentin L, et al. Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 2005;115:369-378. (Pubitemid 40385478)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.2
, pp. 369-378
-
-
Contri, A.1
Brunati, A.M.2
Trentin, L.3
Cabrelle, A.4
Miorin, M.5
Cesaro, L.6
Pinna, L.A.7
Zambello, R.8
Semenzato, G.9
Donella-Deana, A.10
-
10
-
-
33644536722
-
Mechanisms of apoptosis-induction by rottlerin: Therapeutic implications for B-CLL
-
DOI 10.1038/sj.leu.2404113, PII 2404113
-
Ringshausen I, Oelsner M, Weick K, et al. Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL. Leukemia 2006;20:514-520. (Pubitemid 43291752)
-
(2006)
Leukemia
, vol.20
, Issue.3
, pp. 514-520
-
-
Ringshausen, I.1
Oelsner, M.2
Weick, K.3
Bogner, C.4
Peschel, C.5
Decker, T.6
-
11
-
-
58149376457
-
Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL
-
Pekarsky Y, Palamarchuk A, Maximov V, et al. Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL. Proc Natl Acad Sci USA 2008;105:19643-19648.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19643-19648
-
-
Pekarsky, Y.1
Palamarchuk, A.2
Maximov, V.3
-
12
-
-
33746817989
-
B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
-
DOI 10.1073/pnas.0604564103
-
Yan XJ, Albesiano E, Zanesi N, et al. B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2006; 103:11713-11718. (Pubitemid 44182516)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.31
, pp. 11713-11718
-
-
Yan, X.-J.1
Albesiano, E.2
Zanesi, N.3
Yancopoulos, S.4
Sawyer, A.5
Romano, E.6
Petlickovski, A.7
Efremov, D.G.8
Croce, C.M.9
Chiorazzi, N.10
-
13
-
-
31544471656
-
Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Eμ-TCL1 transgenic mice
-
DOI 10.1158/0008-5472.CAN-05-3426
-
Yan XJ, Albesiano E, Zanesi N, et al. Eff ect of rapamycin on mouse chronic lymphocytic leukemia and the development of non hematopoietic malignancies in Emu-TCL1 transgenic mice. Cancer Res 2006;66:915-920. (Pubitemid 43165958)
-
(2006)
Cancer Research
, vol.66
, Issue.2
, pp. 915-920
-
-
Zanesi, N.1
Aqeilan, K.2
Drusco, A.3
Kaou, M.4
Sevignani, C.5
Costinean, S.6
Bortesi, L.7
La Rocca, G.8
Koldovsky, P.9
Volinia, S.10
Mancini, R.11
Calin, G.12
Scott, C.P.13
Pekarsky, Y.14
Croce, C.M.15
-
14
-
-
63849093256
-
PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: Validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia
-
Holler C, Piñ ón JD, Denk U, et al. PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. Blood 2009;113:2791-2794.
-
(2009)
Blood
, vol.113
, pp. 2791-2794
-
-
Holler, C.1
Piñón, J.D.2
Denk, U.3
-
15
-
-
34848833908
-
Enzastaurin
-
DOI 10.1097/CCO.0b013e3282f10a00, PII 0000162220071100000009
-
Ma S, Rosen ST. Enzastaurin. Curr Opin Oncol 2007;19:590-595. (Pubitemid 47508866)
-
(2007)
Current Opinion in Oncology
, vol.19
, Issue.6
, pp. 590-595
-
-
Ma, S.1
Rosen, S.T.2
-
16
-
-
23844521568
-
The protein kinase Cβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
DOI 10.1158/0008-5472.CAN-05-0071
-
Graff JR, McNulty AM, Hanna KR, et al. Th e protein kinase Cbetaselective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005; 65:7462-7469. (Pubitemid 41161281)
-
(2005)
Cancer Research
, vol.65
, Issue.16
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
Konicek, B.W.4
Lynch, R.L.5
Bailey, S.N.6
Banks, C.7
Capen, A.8
Goode, R.9
Lewis, J.E.10
Sams, L.11
Huss, K.L.12
Campbell, R.M.13
Iversen, P.W.14
Neubauer, B.L.15
Brown, T.J.16
Musib, L.17
Geeganage, S.18
Thornton, D.19
-
17
-
-
4243406643
-
Phase I study of LY317615, a protein kinase Cβinhibitor
-
Abstract 326
-
Herbst R, Th ornton DE, Kies MS, et al. Phase I study of LY317615, a protein kinase Cβinhibitor. Proc Am Soc Clin Oncol 2002;21(Suppl.): Abstract 326.
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, vol.21
, Issue.SUPPL.
-
-
Herbst, R.1
Thornton, D.E.2
Kies, M.S.3
-
18
-
-
33745204140
-
Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor
-
Green LJ, Marder P, Ray C, et al. Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor. Clin Cancer Res 2006;12:3408-3415.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 3408-3415
-
-
Green, L.J.1
Marder, P.2
Ray, C.3
-
19
-
-
61849179573
-
Targeting PKC: A novel role for beta-catenin in ER stress and apoptotic signaling
-
Raab M, Breitkreutz I, Tonon G, et al. Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling. Blood 2009;113:1513-1521.
-
(2009)
Blood
, vol.113
, pp. 1513-1521
-
-
Raab, M.1
Breitkreutz, I.2
Tonon, G.3
-
20
-
-
74249107839
-
Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70
-
zum Büschenfelde CM, Wagner M, Lutzny G, et al. Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70. Leukemia 2010;24:141-152.
-
(2010)
Leukemia.
, vol.24
, pp. 141-152
-
-
Zum Büschenfelde, C.M.1
Wagner, M.2
Lutzny, G.3
-
21
-
-
78650434193
-
Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis
-
Dumstorf CA, Konicek BW, McNulty AM, et al. Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis. Mol Cancer Th er 2010;9:3158-3163.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 3158-3163
-
-
Dumstorf, C.A.1
Konicek, B.W.2
McNulty, A.M.3
-
22
-
-
38049166147
-
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
-
Liu Q, Zhao X, Frissora F, et al. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 2008;111:275-284.
-
(2008)
Blood
, vol.111
, pp. 275-284
-
-
Liu, Q.1
Zhao, X.2
Frissora, F.3
-
23
-
-
0038603190
-
PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A
-
DOI 10.1182/blood-2002-10-3208
-
Moon EY, Lerner A. PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A. Blood 2003;101:4122-4130. (Pubitemid 36857894)
-
(2003)
Blood
, vol.101
, Issue.10
, pp. 4122-4130
-
-
Moon, E.-Y.1
Lerner, A.2
-
24
-
-
0032914280
-
Expressions of four major protein Ser/Thr phosphatases in human primary leukemic cells
-
Yamamoto M, Suzuki Y, Kihira H, et al. Expressions of four major protein Ser/Th r phosphatases in human primary leukemic cells. Leukemia 1999;13:595-600. (Pubitemid 29195289)
-
(1999)
Leukemia
, vol.13
, Issue.4
, pp. 595-600
-
-
Yamamoto, M.1
Suzuki, Y.2
Kihira, H.3
Miwa, H.4
Kita, K.5
Nagao, M.6
Tamura, S.7
Shiku, H.8
Nishikawa, M.9
-
26
-
-
1842555111
-
Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells
-
DOI 10.1080/10428190310001639470
-
Th omas A, Pepper C, Hoy T, et al. Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular diff erentiation and resistance to druginduced apoptosis in B-cell chronic lymphocytic leukemia cells. Leuk Lymphoma 2004;45:997-1008. (Pubitemid 38444677)
-
(2004)
Leukemia and Lymphoma
, vol.45
, Issue.5
, pp. 997-1008
-
-
Thomas, A.1
Pepper, C.2
Hoy, T.3
Bentley, P.4
-
27
-
-
34249746834
-
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia
-
DOI 10.1182/blood-2006-10-054577
-
Moreau AS, Jia X, Ngo HT, et al. Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenström macroglobulinemia. Blood 2007;109:4964-4972. (Pubitemid 46827795)
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4964-4972
-
-
Moreau, A.-S.1
Jia, X.2
Ngo, H.T.3
Leleu, X.4
O'Sullivan, G.5
Alsayed, Y.6
Leontovich, A.7
Podar, K.8
Kutok, J.9
Daley, J.10
Lazo-Kallanian, S.11
Hatjiharissi, E.12
Raab, M.S.13
Xu, L.14
Treon, S.P.15
Hideshima, T.16
Anderson, K.C.17
Ghobrial, I.M.18
-
28
-
-
58849089256
-
Protein phosphatase 2A inactivates Bcl2' s antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
-
Deng X, Gao F, May WS. Protein phosphatase 2A inactivates Bcl2' s antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding. Blood 2009;113:422-428.
-
(2009)
Blood
, vol.113
, pp. 422-428
-
-
Deng, X.1
Gao, F.2
May, W.S.3
-
29
-
-
77958038959
-
Effi cacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context
-
Kuo WL, Liu J, Mauceri H, et al. Effi cacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Th er 2010;9:2814-2824.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 2814-2824
-
-
Kuo, W.L.1
Liu, J.2
Mauceri, H.3
-
30
-
-
33747368704
-
PP-2A regulates Bcl-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum
-
Lin SS, Bassik MC, Suh H, et al. PP-2A regulates Bcl-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 2006;281:23003-23012.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 23003-23012
-
-
Lin, S.S.1
Bassik, M.C.2
Suh, H.3
-
31
-
-
70349284466
-
Th e tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression
-
Baudot AD, Jeandel PY, Mouska X, et al. Th e tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression. Oncogene 2009;28:3261-3273.
-
(2009)
Oncogene
, vol.28
, pp. 3261-3273
-
-
Baudot, A.D.1
Jeandel, P.Y.2
Mouska, X.3
|