Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells

Leukemia and Lymphoma

Volumn 45, Issue 5, 2004, Pages 997-1008

  Thomas, Alun ^a   Pepper, Chris ^a   Hoy, Terry ^b   Bentley, Paul ^a  

^a LLANDOUGH HOSPITAL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Bryostatin; CLL; Differentiation; Protein kinase C

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; APOPTOSIS INHIBITOR; BRYOSTATIN; CHLORAMBUCIL; CLADRIBINE; FLUDARABINE; GLYCOPROTEIN P 15095; INHIBITOR OF APOPTOSIS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; PROTEIN MCL 1; SERINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CANCER RESISTANCE; CELL DIFFERENTIATION; CELL SIZE; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CROSS REACTIVITY; DRUG POTENTIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

APOPTOSIS; CELL DIFFERENTIATION; DRUG RESISTANCE, NEOPLASM; HUMANS; LACTONES; LEUKEMIA, B-CELL, CHRONIC; MACROLIDES; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 1842555111     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190310001639470     Document Type: Article

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