Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor

Journal of Pharmacology and Experimental Therapeutics

Volumn 341, Issue 2, 2012, Pages 493-499

  Pini, Alessandro ^a   Viappiani, Serena ^b   Bolla, Manlio ^b   Masini, Emanuela ^a   Bani, Daniele ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b NicOx SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 BIS(NITROOXY)HEXYL 2 (6 METHOXYNAPHTHALEN 2 YL)PROPANOATE; 8 HYDROXYDEOXYGUANOSINE; ANTIINFLAMMATORY AGENT; BLEOMYCIN; DNA; MYELOPEROXIDASE; NAPROXEN; NCX 466; NITRIC OXIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE CONTROL; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOLOGY; LUNG FIBROSIS; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; RESPIRATORY TRACT DISEASE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; COLLAGEN; CYCLOOXYGENASE INHIBITORS; DEOXYGUANOSINE; DINOPROSTONE; INFLAMMATION; LUNG; MALE; MICE; MICE, INBRED C57BL; NAPROXEN; NITRATES; NITRIC OXIDE; NITRIC OXIDE DONORS; OXIDATIVE STRESS; PEROXIDASE; PROPIONATES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PULMONARY FIBROSIS; THIOBARBITURATES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84859984024     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.190660     Document Type: Article

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