The T-T genotype within the NME1 promoter single nucleotide polymorphism -835 C/T is associated with an increased risk of cytarabine induced neurotoxicity in patients with acute myeloid leukemia

Leukemia and Lymphoma

Volumn 53, Issue 5, 2012, Pages 952-957

  Braunagel, Dominic ^a   Schaich, Markus ^b   Kramer, Michael ^b   Dransfeld, Christian Lars ^a   Ehninger, Gerhard ^b   Mahlknecht, Ulrich ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

genetic and other predisposing conditions; molecular genetics; Myeloid leukemias and dysplasias

Indexed keywords

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; AMSACRINE; CREATININE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; MITOXANTRONE; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BEHAVIOR DISORDER; CANCER PROGNOSIS; CAUCASIAN; CELL DAMAGE; CEREBELLUM; CONTINUOUS INFUSION; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; DNA DAMAGE; EASTERN COOPERATIVE ONCOLOGY GROUP PERFORMANCE STATUS; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NERVE CELL NECROSIS; NEUROTOXICITY; NME1 GENE; NONHUMAN; ONCOGENE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; RAT; RETROSPECTIVE STUDY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE COUNT; TREATMENT DURATION;

ACETYLCYSTEINE; ADOLESCENT; ADULT; AGED; APOPTOSIS; CYTARABINE; FEMALE; GENOTYPE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; NEURONS; NEUROTOXICITY SYNDROMES; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RETROSPECTIVE STUDIES; SURVIVAL RATE; YOUNG ADULT;

EID: 84859982399     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.635862     Document Type: Article

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