Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health

Journal of Periodontal Research

Volumn 47, Issue 3, 2012, Pages 389-395

  Al Sabbagh, M ^a   Alladah, A ^a   Lin, Y ^a   Kryscio, R J ^a   Thomas, M V ^a   Ebersole, J L ^a   Miller, C S ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

C terminal type I collagen telopeptide; Biomarker; Bone remodeling; C telopeptide pyridinoline cross links of type I collagen; Macrophage inflammatory protein 1 ; Osteoprotegerin; Periodontal disease; Periodontal health; Saliva

Indexed keywords

BIOLOGICAL MARKER; COLLAGEN TYPE 1; COLLAGEN TYPE I TRIMERIC CROSS LINKED PEPTIDE; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OSTEOPROTEGERIN; PEPTIDE; SALIVA PROTEIN; TNFRSF11B PROTEIN, HUMAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BONE REMODELING; CASE CONTROL STUDY; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; FEMALE; GINGIVA BLEEDING; HUMAN; MALE; METABOLISM; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; PERIODONTIUM; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY;

ADULT; AREA UNDER CURVE; BIOLOGICAL MARKERS; BONE REMODELING; CASE-CONTROL STUDIES; CHEMOKINE CCL3; CHRONIC PERIODONTITIS; COLLAGEN TYPE I; CROSS-SECTIONAL STUDIES; FEMALE; GINGIVAL HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; OSTEOPROTEGERIN; PEPTIDES; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTIUM; SALIVARY PROTEINS AND PEPTIDES; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84859977823     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2011.01445.x     Document Type: Article

References (55)

1. Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol 1996;1:821-878.
2. Ranney RR. Immunologic mechanisms of pathogenesis in periodontal diseases: an assessment. J Periodontal Res 1991;26:243-254.
3. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 1991;26:230-242.
4. Seymour GJ. Importance of the host response in the periodontium. J Clin Periodontol 1991;18:421-426.
5. Genco RJ. Host responses in periodontal diseases: current concepts. J Periodontol 1992;63:338-355.
6. Dennison DK, Van Dyke TE. The acute inflammatory response and the role of phagocytic cells in periodontal health and disease. Periodontol 2000 1997;14:54-78.
7. Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocytic response. Crit Rev Oral Biol Med 2002;13:17-34.
8. Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis - a review. J Clin Periodontol 2000;27:453-465.
9. Lamster IB, Kaufman E, Grbic JT, Winston LJ, Singer RE. Beta-glucuronidase activity in saliva: relationship to clinical periodontal parameters. J Periodontol 2003;74:353-359.
10. Christodoulides N, Mohanty S, Miller CS et al. Application of microchip assay system for the measurement of C-reactive protein in human saliva. Lab Chip 2005;5:261-269.
11. Miller CS, King CP Jr, Langub MC, Kryscio RJ, Thomas MV. Salivary biomarkers of existing periodontal disease: a cross-sectional study. J Am Dent Assoc 2006;137:322-329.
12. Herr AE, Hatch AV, Throckmorton DJ et al. Microfluidic immunoassays as rapid saliva-based clinical diagnostics. Proc Natl Acad Sci U S A 2007;104:5268-5273.
13. Miller CS, Foley JD, Bailey AL et al. Current developments in salivary diagnostics. Biomark Med 2010;4:1-18.
14. Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000 2009;50:52-64.
15. Buduneli N, Kinane DF. Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol 2011;38(Suppl 11):85-105.
16. Pfeilschifter J, Chenu C, Bird A, Mundy GR, Roodman GD. Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro. J Bone Miner Res 1989;4:113-118.
17. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 1986;319:516-518.
18. Chiang CY, Kyritsis G, Graves DT, Amar S. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun 1999;67:4231-4236.
19. Li L, Khansari A, Shapira L, Graves DT, Amar S. Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun 2002;70:3915-3922.
20. Choi SJ, Cruz JC, Craig F et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 2000;96:671-675.
21. Kotake S, Udagawa N, Takahashi N et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103:1345-1352.
22. Ishimi Y, Miyaura C, Jin CH et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990;145:3297-3303.
23. Lerner UH. Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 2006;85:596-607.
24. Roodman GD. Regulation of osteoclast differentiation. Ann N Y Acad Sci 2006;1068:100-109.
25. Mogi M, Otogoto J. Expression of cathepsin-K in gingival crevicular fluid of patients with periodontitis. Arch Oral Biol 2007;52:894-898.
26. Giannobile WV, Al-Shammari KF, Sarment DP. Matrix molecules and growth factors as indicators of periodontal disease activity. Periodontol 2000 2003;31:125-134.
27. Risteli L, Risteli J. Biochemical markers of bone metabolism. Ann Med 1993;25:385-393.
28. Delmas PD. Bone marker nomenclature. Bone 2001;28:575-576.
29. Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C. Immunoassay for quantifying type I collagen degradation products in urine evaluated. Clin Chem 1994;40:2022-2025.
30. Garnero P, Ferreras M, Karsdal MA et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2003;18:859-867.
31. Garnero P. Biomarkers for osteoporosis management: utility in diagnosis, fracture risk prediction and therapy monitoring. Mol Diagn Ther 2008;12:157-170.
32. Kinney JS, Morelli T, Braun T et al. Saliva/pathogen biomarker signatures and periodontal disease progression. J Dent Res 2011;90:752-758.
33. Frodge BD, Ebersole JL, Kryscio RJ, Thomas MV, Miller CS. Bone remodeling biomarkers of periodontal disease in saliva. J Periodontol 2008;79:1913-1919.
34. Fine DH, Markowitz K, Furgang D et al. Macrophage inflammatory protein-1alpha: a salivary biomarker of bone loss in a longitudinal cohort study of children at risk for aggressive periodontal disease? J Periodontol 2009;80:106-113.
35. Ng PY, Donley M, Hausmann E, Hutson AD, Rossomando EF, Scannapieco FA. Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vitro studies. FEMS Immunol Med Microbiol 2007;49:252-260.
36. Scannapieco FA, Ng P, Hovey K, Hausmann E, Hutson A, Wactawski-Wende J. Salivary biomarkers associated with alveolar bone loss. Ann N Y Acad Sci 2007;1098:496-497.
37. Teles RP, Likhari V, Socransky SS, Haffajee AD. Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. J Periodontal Res 2009;44:411-417.
38. Gurlek O, Lappin DF, Buduneli N. Effects of smoking on salivary C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels. Arch Oral Biol 2009;54:1099-1104.
39. Ozcaka O, Nalbantsoy A, Buduneli N. Salivary osteocalcin levels are decreased in smoker chronic periodontitis patients. Oral Dis 2011;17:200-205.
40. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
41. Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000 2004;34:9-21.
42. Sexton WM, Lin Y, Kryscio RJ, Dawson DR 3rd, Ebersole JL, Miller CS. Salivary biomarkers of periodontal disease in response to treatment. J Clin Periodontol 2011;38:434-441.
43. Navazesh M. Methods for collecting saliva. Ann N Y Acad Sci 1993;694:72-77.
44. Everts V, Delaisse JM, Korper W, Beertsen W. Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone. J Bone Miner Res 1998;13:1420-1430.
45. Koizumi M, Matsumoto S, Takahashi S, Yamashita T, Ogata E. Bone metabolic markers in the evaluation of bone scan flare phenomenon in bone metastases of breast cancer. Clin Nucl Med 1999;24:15-20.
46. Costa PP, Trevisan GL, Macedo GO et al. Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol 2010;81:384-391.
47. Buduneli N, Biyikoglu B, Sherrabeh S, Lappin DF. Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients. J Clin Periodontol 2008;35:846-852.
48. Ramseier CA, Kinney JS, Herr AE et al. Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol 2009;80:436-446.
49. El-Sharkawy H, Aboelsaad N, Eliwa M et al. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin. J Periodontol 2010;81:1635-1643.
50. Menten P, Wuyts A, Van Damme J. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev 2002;13:455-481.
51. Ryu OH, Choi SJ, Linares AM et al. Gingival epithelial cell expression of macrophage inflammatory protein-1alpha induced by interleukin-1beta and lipopolysaccharide. J Periodontol 2007;78:1627-1634.
52. Maurer M, von Stebut E. Macrophage inflammatory protein-1. Int J Biochem Cell Biol 2004;36:1882-1886.
53. Terpos E, Politou M, Viniou N, Rahemtulla A. Significance of macrophage inflammatory protein-1 alpha (MIP-1alpha) in multiple myeloma. Leuk Lymphoma 2005;46:1699-1707.
54. Morandini AC, Sipert CR, Gasparoto TH et al. Differential production of macrophage inflammatory protein-1alpha, stromal-derived factor-1, and IL-6 by human cultured periodontal ligament and gingival fibroblasts challenged with lipopolysaccharide from P. gingivalis. J Periodontol 2010;81:310-317.
55. Christodoulides N, Floriano PN, Miller CS et al. Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis. Ann N Y Acad Sci 2007;1098:411-428.