Aerosolized antibiotics: The past, present and future, with a special emphasis on inhaled colistin

Expert Opinion on Drug Delivery

Volumn 9, Issue 5, 2012, Pages 493-495

  Michalopoulos, Argyris S ^a  

^a HENRY DUNANT HOSPITAL   (Greece)

Author keywords

aerosolized antibiotics; aerosolized colistin; inhaled colistin; inhaled polymyxins

Indexed keywords

ANTIBIOTIC AGENT; COLISTIMETHATE; COLISTIN;

AEROSOL; ANTIBIOTIC THERAPY; BRONCHIECTASIS; CHEST TIGHTNESS; COUGHING; CYSTIC FIBROSIS; DISEASE CONTROL; DRUG EFFICACY; FOOD AND DRUG ADMINISTRATION; GRAM NEGATIVE BACTERIUM; HOSPITAL ACQUIRED PNEUMONIA; HOSPITAL INFECTION; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NEBULIZER; PNEUMONIA; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; THROAT IRRITATION; VENTILATOR ASSOCIATED PNEUMONIA;

ADMINISTRATION, INHALATION; ANTI-BACTERIAL AGENTS; COLISTIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FORECASTING; HUMANS; NASAL SPRAYS; PNEUMONIA, VENTILATOR-ASSOCIATED; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS;

EID: 84859971768     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.676039     Document Type: Review

References (20)

1. Nikiforov VN. Inhalation of penicillin, streptomycin, and novocaine solution aerosols in the treatment of resistant diphtherial bacterial carriers. Pediatriia 1954;4:53-4
2. Venerando A, Maffei R. Use of combined trypsin and antibiotics in inhalation therapy of some bronchial diseases. Minerva Med 1955;46(67-68):385-9
3. Ramsey BW, Pepe MS, Quan JM, et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N Engl J Med 1999;340(1):23-30 (Pubitemid 29024680)
4. Ratjen F, Doring G, Nikolaizik WH. Effect of inhaled tobramycin on early Pseudomonas aeruginosa colonisation in patients with cystic fibrosis. Lancet 2001;358(9286):983-4 (Pubitemid 32913526)
5. Hansen CR, Pressler T, Hoiby N. Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience. J Cyst Fibros 2008;7(6):523-30
6. Drugs.com. FDA Approves Dulera. Available from: www.drugs.com/newdrugs/~ [Accessed 17 November 2010]
7. European Medicines Agency. Aztreonam lysine (Cayston) powder and solvent for nebulizer solution: Summary of product characteristics. Available from: www.ema.europa.eu/ema/index.jsp? curl=search.jsp~ [Accessed 16 July 2010]
8. Ioannidou E, Siempos II, Falagas ME. Administration of antimicrobials via the respiratory tract for the treatment of patients with nosocomial pneumonia: A meta-Analysis. J Antimicrob Chemother 2007;60(6):1216-26 (Pubitemid 350168316)
9. Sermet-Gaudelus I, Le Cocguic Y, Ferroni A, et al. Nebulized antibiotics in cystic fibrosis. Paediatr Drugs 2002;4(7):455-67 (Pubitemid 34765437)
10. Geller DE. Aerosol antibiotics in cystic fibrosis. Respir Care 2009;54(5):658-70
11. Wood GC, Swanson JM. Aerosolised antibacterials for the prevention and treatment of hospital-Acquired pneumonia. Drugs 2007;67:903-14 (Pubitemid 46607390)
12. Michalopoulos A, Metaxas EI, Falagas ME. Aerosol Delivery of Antimicrobial Agents During Mechanical Ventilation: Current Practice and Perspectives. Curr Drug Deliv 2011;8(2):208-12
13. Michalopoulos A, Fotakis D, Virtzili S, et al. Aerosolized colistin as adjunctive treatment of ventilator-Associated pneumonia due to multidrug-resistant Gram-negative bacteria: A prospective study. Respir Med 2008;102(3):407-12 (Pubitemid 351179979)
14. Korbila I, Michalopoulos A, Rafailidis P, et al. Inhaled colistin as adjunctive to intravenous colistin for the treatment of microbiologically documented ventilator-Associated pneumonia: A comparative cohort study. Clin Microbiol Infect 2010;16(8):1230-6
15. American Thoracic Society/Infectious Diseases Society of America. Guidelines for the management of adults with hospital-Acquired, ventilator-Associated, and healthcareassociated pneumonia. Am J Respir Crit Care 2005;171:388-416
16. Le J, Ashley ED, Newhauser MM, et al. Consensus summary of aerosolized antimicrobial agents: Application of guideline criteria. Pharmacother 2010;30:562-84
17. Antoniu SA, Cojocaru I. Inhaled colistin for lower respiratory tract infections. Expert Opin Drug Deliv 2012;9(3):333-42
18. Michalopoulos A, Kasiakou S, Falagas M. The significance of different formulations of aerosolized colistin. Crit Care 2005;9:417-18 (Pubitemid 41136288)
19. Arnold HM, Sawyer AM, Kollef MH. Use of adjunctive aerosolized antimicrobial therapy in the treatment of pseudomonas aeruginosa and Acinetobacter baumannii ventilator-Associated pneumonia. Respir Care 2012; Epub ahead of print
20. Lin CC, Liu TC, Kuo CF, et al. Aerosolized colistin for the treatment of multidrug-resistant Acinetobacter baumannii pneumonia: Experience in a tertiary care hospital in northern Taiwan. J Microbiol Immunol Infect 2010;43(4):323-31