Isopentenyl diphosphate isomerase catalyzed reactions in D 2O: Product release limits the rate of this sluggish enzyme-catalyzed reaction

Journal of the American Chemical Society

Volumn 134, Issue 15, 2012, Pages 6568-6570

  Jonnalagadda, Venkatadurga ^a   Toth, Krisztina ^a   Richard, John P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYZED REACTIONS; DIPHOSPHATES; E. COLI; ENCOUNTER COMPLEX; ENZYME-CATALYZED REACTIONS; ISOPENTENYL DIPHOSPHATE; ISOPENTENYL DIPHOSPHATE ISOMERASE (IDI); KINETIC BARRIER; LIGAND BINDING; METAL CATION; METHYL GROUP; MICHAELIS COMPLEX; PRODUCT RELEASE; RATE CONSTANT K;

COMPENSATION (PERSONNEL); DEUTERIUM; ENZYMES; ESCHERICHIA COLI; FUNCTIONAL GROUPS; RATE CONSTANTS;

CATALYSIS;

2 AMINO ETHYL DIPHOSPHATE; DEUTERIUM; DIMETHYLALLYL DIPHOSPHATE; ENZYME; ISOPENTENYL DIPHOSPHATE; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; ESCHERICHIA COLI; ISOMERIZATION; KINETICS; LIGAND BINDING; NONHUMAN; PROTON TRANSPORT; YEAST;

CARBON-CARBON DOUBLE BOND ISOMERASES; CATALYSIS; DEUTERIUM OXIDE; ESCHERICHIA COLI; HEMITERPENES; KINETICS; ORGANOPHOSPHORUS COMPOUNDS;

EID: 84859968516     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja302154k     Document Type: Article

References (23)

1. Agranoff, B. W.; Eggerer, H.; Henning, U.; Lynen, F. J. Am. Chem. Soc. 1959, 81, 1254-1255
2. Reardon, J. E.; Abeles, R. H. Biochemistry 1986, 25, 5609-5616
3. Muehlbacher, M.; Poulter, C. D. Biochemistry 1988, 27, 7315-7328
4. Kuzuyama, T.; Seto, H. Nat. Prod. Rep. 2003, 20, 171-183
5. Toteva, M. M.; Richard, J. P. J. Am. Chem. Soc. 1996, 118, 11434-11445
6. Lee, S.; Poulter, C. D. J. Am. Chem. Soc. 2006, 128, 11545-11550
7. Street, I. P.; Christensen, D. J.; Poulter, C. D. J. Am. Chem. Soc. 1990, 112, 8577-8578
8. Street, I. P.; Coffman, H. R.; Baker, J. A.; Poulter, C. D. Biochemistry 1994, 33, 4212-4217
9. Clifford, K.; Cornforth, J. W.; Mallaby, R.; Phillips, G. T. J. Chem. Soc. D 1971, 1599-1600
10. Zhang, C.; Liu, L.; Xu, H.; Wei, Z.; Wang, Y.; Lin, Y.; Gong, W. J. Mol. Biol. 2007, 366, 1437-1446
11. Durbecq, V.; Sainz, G.; Oudjama, Y.; Clantin, B.; Bompard-Gilles, C.; Tricot, C.; Caillet, J.; Stalon, V.; Droogmans, L.; Villeret, V. EMBO J. 2001, 20, 1530-1537
12. Wouters, J.; Oudjama, Y.; Barkley, S. J.; Tricot, C.; Stalon, V.; Droogmans, L.; Poulter, C. D. J. Biol. Chem. 2003, 278, 11903-11908
13. Wouters, J.; Oudjama, Y.; Stalon, V.; Droogmans, L.; Poulter, C. D. Proteins 2004, 54, 216-221
14. Toteva, M. M.; Richard, J. P. Bioorg. Chem. 1997, 25, 239-245
15. ODonoghue, A. C.; Amyes, T. L.; Richard, J. P. Biochemistry 2005, 44, 2622-2631
16. Amyes, T. L.; Richard, J. P. Biochemistry 2007, 46, 5841-5854
17. Goryanova, B.; Amyes, T. L.; Gerlt, J. A.; Richard, J. P. J. Am. Chem. Soc. 2011, 133, 6545-6548
18. Street, I. P.; Coffman, H. R.; Poulter, C. D. Tetrahedron 1991, 31, 5919-5924
19. Hahn, F. M.; Hurlburt, A. P.; Poulter, C. D. J. Bacteriol. 1999, 181, 4499-4504
20. Carrigan, C. N.; Poulter, C. D. J. Am. Chem. Soc. 2003, 125, 9008-9009
21. Rios, A.; Richard, J. P.; Amyes, T. L. J. Am. Chem. Soc. 2002, 124, 8251-8259
22. Rios, A.; Amyes, T. L.; Richard, J. P. J. Am. Chem. Soc. 2000, 122, 9373-9385
23. Knowles, J. R.; Albery, W. J. Acc. Chem. Res. 1977, 10, 105-111