Recombinant human activated protein C (Xigris) attenuates murine cerulein-induced acute pancreatitis via regulation of nuclear factor κb and apoptotic pathways

Pancreas

Volumn 41, Issue 4, 2012, Pages 619-628

  Babu, Benoy I ^a   Genovese, Tiziana ^b   Mazzon, Emanuela ^c   Riccardi, Luisa ^b   Paterniti, Irene ^b   Galuppo, Maria ^b   Crisafulli, Concetta ^b   Siriwardena, Ajith K ^a   Cuzzocrea, Salvatore ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MESSINA   (Italy)

^c IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

Author keywords

acute pancreatitis; apoptosis; cytokines; neutrophils; NF B; Xigr is

Indexed keywords

CERULETIDE; DROTRECOGIN; FAS LIGAND; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; PADGEM PROTEIN; PROTEIN BAX; PROTEIN BCL 2; SELECTIN; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEMORRHAGIC PANCREATITIS; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD CLOTTING PARAMETERS; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOKINE RESPONSE; DENSITOMETRY; ENDOTHELIUM INJURY; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANCREAS HEMORRHAGE; PANCREAS INJURY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; VASCULAR PATENCY;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CAERULEIN; CYTOKINES; FIBRINOLYTIC AGENTS; IN SITU NICK-END LABELING; MALE; MALONDIALDEHYDE; NF-KAPPA B; PANCREAS; PANCREATITIS, ACUTE NECROTIZING; PEROXIDASE; PROTEIN C; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 84859962247     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31823ca26d     Document Type: Article

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