Synthesis of 2'-(5-Chloro-2-Hydroxybenzylidene) benzenesulfanohydrazide schiff base and its anti-ulcer activity in ethanol-induced gastric mucosal lesions in rats

Tropical Journal of Pharmaceutical Research

Volumn 11, Issue 2, 2012, Pages 251-257

  Gwaram, Nura S ^a   Musalam, Laila ^a   Ali, Hapipah M ^a   Abdulla, Mahmood A ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Benzenesulfanohydrazone; Gastric ulcer; Histology; Schiff base

Indexed keywords

2 (5 CHLORO 2 HYDROXYBENZYLIDENE)BENZENESULFANOHYDRAZIDE; ANTIULCER AGENT; CIMETIDINE; SCHIFF BASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; INFRARED SPECTROSCOPY; LOW DRUG DOSE; MALE; MUCOSAL NECROSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH CONTENT; STOMACH MUCOSA LESION; STOMACH MUCUS; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER; STRUCTURE ANALYSIS; TREATMENT DURATION;

EID: 84859953163     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v11i2.11     Document Type: Article

References (13)

1. Patrick LG. An Introduction to Medicinal Chemistry, edn 2, Oxford University Press, New York, 2001.
2. Tawfik H, Magdy MB, Kamal MI. Ligational, thermal, corrosion inhibition and antimicrobial properties of salicyidinebenzenesulphonylhydrazone. Trans Met Chem 1989; 14: 371-374.
3. Hapipah MA, Puvaneswary S, Jefri BW. Synthesis Characterization Electrochemistry and antimicrobial activity of Zinc (II) Complexes of some Hydrazone Schiff Bases. Malay J Sci 2006; 25(1): 107-114.
4. Paola VA, Athina GB, Matteo IA, Bernadetta BG. Synthesis and biological evaluation of benzo[d]isothiazole, benzothiazole and thiazole Schiff bases, J Bioorg Med Chem. 2003; 11: 4785-4789.
5. Wasman SQ, Mahmood AA, Salehhuddin HA, Zahra SI. Cytoprotective activities of Polygonum minus aqueous leaf extract on ethanol-induced gastric ulcer in rats. J Med Pl Res. 2010; 4(24): 2658-2665.
6. Abdulla MA, Ahmed KAA, AL-Bayaty FH, Masood Y. Gastroprotective effect of Phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats. Afr J Pharm Pharmacol 2010; 4(5): 226-230.
7. Mahmood AA, Mariod AA, Al-Bayaty F, Abdel-Wahab DI. Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats. J Med Plant Res 2010; 4(8): 685-691.
8. Al-Shabanah OA, Raza M, Al-Harbi M, Al-Bekairi AM, Qureshi S. Effect of ninhydrin on the biochemical and histopathological changes induced by ethanol in gastric mucosa of rats. J Life Sci. 2000; 67: 559-566.
9. Murakamu S, Kijima H, Isob Y. Effects of salvianolic acid A on gastric H+, K+, -ATPase. Planta Medica. 1990; 56: 360-363.
10. Njar VCO, Adesanwo JK, Raji Y. Methyl Angolensate: The antiulcer agent of stem bark of Etandrophragma angolense, Planta Medica 1995; 61: 91-92.
11. Repetto MG., Liesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcer. Braz J Med Biol Res 2002; 35: 523-534.
12. Rajeshkumar NV, Theresa M, Kuttan Emblica Officinalis Fruits Afford Protection against experimental gastric ulcer. Pharmaceut Biol. 2001; 39(5): 375-380.
13. Hollander D, Tarnwaski A, Gergely H, Zipser RD. Sucralfate protection of gastric mucosa against ethanol-induced injury, Scand J Gastroent 1984; 19: 97-102.