Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats

Journal of Medicinal Plants Research

Volumn 4, Issue 8, 2010, Pages 685-691

  Mahmood, A A ^a   Mariod, Abdalbasit A ^b   Al Bayaty, Fouad ^c   Abdel Wahab, Siddig Ibrahim ^d  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b SUDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Sudan)

^c UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^d NONE

Author keywords

Cytoprotection; Ethanolic extract; Gastric ulcer; Gynura procumbens; Histology

Indexed keywords

ALCOHOL; ANTIULCER AGENT; CARBOXYMETHYLCELLULOSE; GYNURA PROCUMBENS EXTRACT; OMEPRAZOLE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EDEMA; FEMALE; GYNURA PROCUMBENS; HISTOPATHOLOGY; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; RAT; RECOMMENDED DRUG DOSE; SPRAGUE DAWLEY RAT; STOMACH INJURY; STOMACH LESION; STOMACH MUCOSA INJURY; STOMACH PROTECTION; STOMACH ULCER; TOXICITY TESTING; ULCEROGENESIS;

GYNURA; RATTUS;

EID: 77951935453     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Akowuah GA, Sadikun A, Mariam A (2002). Flavonoid identification and hypoglycemic studies of butanol fraction from Gynura procumbens. Pharmaceut. Biol. 40: 405-410.
2. Al-Mofleh IA, Alhaider AA, Mossa JS, AlSohaibani MO, Al-Yahya MA, Rafatulla S, Shaik SA (2008). Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals. Saudi J. Gastroenterol. 14: 128-134.
3. Al-Mofleh IA, Alhaider AA, Mossa JS, Al-Soohaibani MO, Rafatullah S (2007). Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers. World J. Gastroenterol. 13: 1112-1118.
4. Baron TH, Langman MTS, Wastell C (1980). Stomach and duodenum. In: I.A.D/ Bouchier (Ed.), Recent Advances in Gastroenterology. Churehill Livingstone, London pp. 23-29.
5. Bergmeyer HU (1980). IFCC method for the measurement of catalytic concentrations of enzymes. Part 3. IFCC method for alanine minotransferase. Clinica Chimica Acta 105: 147-154.
6. Bou-Abboud CF, Wayland H, Panlsen G, Guth PH (1988). Microcirculatory stasis precedes tissue necrosis in ethanol-induced gastric mucosal injury in rat. Dig. Dis. Sci. 33: 872-877.
7. Cheng CL, Koo MWL (2000). Effect of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sci. 67: 2647-2653.
8. Coelho RG, Gonzalez FG, Sannomiya M, Di Stasi LC, Vilegas W (2009). Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice. Nat. Prod. Res. 23(1): 51-59.
9. De Pasquale R, Germano MP, Keita A, Sanogo R, Lauk L (1995). Antiulcer activity of Pteleopsis suberosa. J. Ethnopharmacol. Ethnopharmacol. 47: 55-58.
10. Devi RS, Kist M, Vani G, Devi CS (2008). Effect of methanolic extract of Terminalia arjuna against Helicobacter pylori 26695 lipopolysaccharide-induced gastric ulcer in rats. J. Pharm. Pharmacol. 60(4): 505-514.
11. Fujita H, Takahashi S, Okabe S (1998). Mechanism by which indomethacin delays the healing of acetic acid-induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities. J. Physiol. Pharmacol. 49: 71-82.
12. Garg GP, Nigam SK, Ogle CW (1993). The gastric antiulcer effects of the leaves of the neem tree. Planta Medica 59: 215-217.
13. Garrick T, Buack S, Bass P (1986). Gastric motility is major factor in cold, restraint induced lesion formation in rats. Am. J. Physiol. 250: 6191-6199.
14. Hiruma-Lima CA, Calvo TR, Rodrigues CM, Andrade FD, Vilegas W, Brito AR (2006). Antiulcerogenic activity of Alchornea castaneafolia: effects on somatostatin, gastrin and prostaglandin. J. ethnopharmacol. 104: 215-224.
15. Iskander MN, Song Y, Coupar IM, Iratchariyakul W (2002). Anti-inflammatory screening of the medicinal plant Gynura procumbens. Plant Foods Human Nutr. 57: 233-244.
16. Kauffman GL, Grossman MI (1978). Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates. Gastroenterology 75: 1099-2102.
17. Khazaei M, Salehi H (2006). Protective effect of Falcaria vulgaris extract on ethanol induced gastric ulcer in rats. Iran J. Pharmacol. Ther. 5: 43-46.
18. Kim M, Lee HL, Wiryowidagdo S, Kim HK (2006). Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats. J. Med. Food 9: 587-590.
19. Kobayashi T, Ohta Y, Yoshino J, Nakazawa S (2001). Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. Pharmacol. Res. 43: 23-30.
20. La Casa C, Villegas I, Alarcon de la Lastra C, Motilva V, Martin Calero MJ (2000). Evidence for protective and antioxidant properties in rutin, a natural flavone, against ethanol induced gastric lesions. J. Ethnopharmacol. 71: 45-53.
21. Lewis DA, Hanson PJ (1991). Antiulcer drugs of plant origin. Progress Med. Chem. 28: 210-229.
22. Li X, Andersson TB, Ahlstom M, Weidolf L (2004). Comparison of inhibitory effects of proton pump inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole on human cytochrome P450 activities. Drug Metab. Dispos. 32: 821-827.
23. Ligumsky M, Sestieri M, Okon F, Ginsburg I (1995). Antioxidants inhibit ethanol-induced gastric injury in the rat. Role of manganese, glycin and carotene. Scandanavian J. Gastroenterol. 30: 854-860.
24. Marhuenda E, Martin MJ, Alarcon de la Lastra C (1993). Antiulcerogenic activity of aescine in different experimental models. Phytother. Res. 7: 13-16.
25. Martin MJ, Marhuenda E, Perez-Guerrero C, Franco JM (1994). Antiulcer effect of naringin on gastric lesion induced by ethanol in rats. Pharmacology 49: 144-150.
26. Mersereau AW, Hinchey EJ (1982). Role of gastric mucosal folds in formation of focal ulcer in rats. Surgery 91: 150-155.
27. Mizui T, Sato H, Hirose F, Doteuchi M (1987). Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats. Life Sci. 41: 755-763.
28. Mutoh H, Hiraishi H, Ota S, Ivey KJ, Terano A, Sugimoto T (1990). Role of oxygen radicals in ethanol-induced damage to cultured gastric mucosal cells. Am. J. Physiol. 258: G603-G609.
29. Nagaya H, Inatomi N, Ohara A, Satoh H (1991). Effects of the enantiomers of lansoprazole (AG-1749) on H+/K+-ATPase activity in canine gastric microsomes and acid formation in isolated canine parietal cells. Biochem. Pharmacol. 42: 1875-1878.
30. Nawawi A, Nakamura N, Hattori M, Kurokawa M, Shiraki K (1999). Inhibitory effects of Indonesian medicinal plants on the infection of herpes simplex virus type-1. Phytother. Res. 13: 37-41.
31. Njar VCO, Adesanwo JK, Raji Y (1995). Methyl angolensate: the antiulcer agent of the stem bark of Entandrophragma angolense. Planta Medica 61: 91-92.
32. Paiva LAF, Rao VSN, Gramosa NV, Silveira FR (1998). Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats. J. Ethnopharmacol. 62: 73-78.
33. Pedernera AM, Guardia T, Caleron CG, Rotelli AF, de la Rocha NF, di Genaro S, Pelze LF (2006). Antiulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. J. Ethnopharmacol. 105: 415-420.
34. Perry LM (1980). Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses, MIT Press, Cambridge, M.A. pp. 94-95.
35. Piper DW, Stiel D (1986). Pathogenesis of chronic peptic ulcer, current thinking and clinical implications. Med. Prog. 2: 7-10.
36. Rosidah YMF, Sadikun A, Ahmad M, Akowuah GA, Asmawi MZ (2009). Toxicology evaluation of standardized methanol extract of g. procumens. J. Ethnopharmacol. 123: 244-249.
37. Satoh H, Inatomi, N, Nagaya H, Ianda I, Nohara, A, Nakamura H (1989). Antisecretory and antiulcer activities of novel proton pump inhibitor AG-1749 in dogs and rats. J. Pharmacol. Exp. Ther. 248: 806-815.
38. Saurez J, Herreta, M.D, Marhuenda E (1996). Hesperidin and neohesperidin dihydrochalcone on different experimental models of induced gastric ulcer. Phytother. Res. 10: 616-618.
39. Shimizu N, Watanabe T, Arakawa T, Fujiwara Y, Higuchi K, Kuroki T (2000). Pentoxifylline accelerates gastric ulcer healing in rats: roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing. Digestion 6: 157-164.
40. Suzuki Y, Ishihara M, Ito M (1998). Anti-ulcer effects of antioxidants, quercetin, α-tocopherol, nifedipine and tetracycline in rats. Japanese J. Pharmacol. 78: 435-441.
41. Szabo S, Kusstatscher S, Sakoulas G, Sandor Z, Vincze AA, Jadus M (1995). 'Growth factors: New "endogeneous drug" for ulcer healing', Scandinavian J. Gastroenterol. 210: 15-18.
42. Takeuch K, Nobuhara Y (1985). Inhibition of gastric motor activity by 16, 16-dimethyl-prostaglandin E2; a probable explanation of cycloprotection. Dig. Dis. Sci. 30: 1181-1188.
43. Takeuchi K, Nishiwakki K, Okabe S (1987). Effect of dopamine on gastric mucosal lesion induced by ethanol in rats-possible involvement of antigastric motor activity mediated with alpha 2 adrenoreceptors. Dig. Dis. Sci. 31: 1100-1107.
44. Tietz NW, Rinker AD, Shaw LM (1983). IFCC methods for the measurement of catalytic concentration of enzymes. Part 5. IFCC method for alkaline phosphatase. J. Clin. Chem. Clin. Biochem. 21: 731-748.
45. Trivedi NP, Rawal UM (2001). Hepatoprotective and antioxidant property of Andrographis paniculata Nees in BHC induced liver damage in mice. Indian J. Exp. Biol. 39: 41-46.
46. Tsukimi Y, Nozue C, Okabe S (1996). Effects of teminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. J. Gastroenterol. Hepatol. 11: 335-340.
47. Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR (2005). Gastroprotective effects of flavonoids in plant extracts. J. Physiol. Pharmacol. 56: 219-231.
48. Zhang XF, Tan BK (2000). Effects of an ethanolic extract of G. procumbens on serum glucose, cholesterol and triglyceride levels in normal and streptozotocin-induced diabetic rats. Singapore Med. J. 41: 9-13.
49. Zimmerman JJ, Ciesielski W, Lewandoski J (1997). Neutrophil-mediated phospholipids peroxidation assessed by gas chromatography-mass spectroscopy. Am. J. Physiol. 273: 653-661.