The DNA glycosylases Ogg1 and Nth1 do not contribute to ig class switching in activated mouse splenic B cells

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Ucher, Anna J ^a   Linehan, Erin K ^a   Teebor, George W ^b   Schrader, Carol E ^a   Stavnezer, Janet ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA GLYCOSYLASE NTH1; DNA GLYCOSYLASE OGG1; DNA GLYCOSYLTRANSFERASE; IMMUNOGLOBULIN HEAVY CHAIN; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); NTH1 PROTEIN, MOUSE; OGG1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ENZYME DEFICIENCY; ENZYME MODIFICATION; GENE INTERACTION; GENE REARRANGEMENT; IMMUNOGLOBULIN STRUCTURE; MOUSE; NONHUMAN; ONCOGENE C MYC; SPLEEN CELL; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; ENZYMOLOGY; GENE INACTIVATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; ONCOGENE MYC; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN;

ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA BREAKS, DOUBLE-STRANDED; DNA GLYCOSYLASES; GENE KNOCKOUT TECHNIQUES; GENES, MYC; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; SPLEEN; TRANSCRIPTION, GENETIC;

EID: 84859949334     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036061     Document Type: Article

References (21)

1. Stavnezer J, Guikema JEJ, Schrader CE, (2008) Mechanism and regulation of class switch recombination. Ann Rev Immunol 26: 261-292.
2. Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, et al. (2008) Two levels of protection for the B cell genome during somatic hypermutation. Nature 451: 841-845.
3. Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, et al. (2008) AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell 135: 1028-1038.
4. Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, et al. (2009) AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 36: 631-641.
5. Yamane A, Resch W, Kuo N, Kuchen S, Li Z, et al. (2011) Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12: 62-69.
6. Staszewski O, Baker RE, Ucher AJ, Martier R, Stavnezer J, et al. (2011) Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells. Mol Cell 41: 232-242.
7. Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, et al. (2007) Regulation of reactive oxygen species by ATM is essential for proper response to DNA double-strand breaks in lymphocytes. J Immunol 178: 103-110.
8. Fedyk ER, Phipps RP, (1994) Reactive oxygen species and not lipoxygenase products are required for mouse B-lymphocyte activation and differentiation. Int J Immunopharmacol 16: 533-546.
9. Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, et al. (2010) p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol 184: 6177-6187.
10. Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, et al. (1999) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A 96: 13300-13305.
11. Ocampo MT, Chaung W, Marenstein DR, Chan MK, Altamirano A, et al. (2002) Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity. Mol Cell Biol 22: 6111-6121.
12. Winter DB, Phung QH, Zeng X, Seeberg E, Barnes DE, et al. (2003) Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase. J Immunol 170: 5558-5562.
13. Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J, (2005) Inducible DNA breaks in Ig S regions are dependent upon AID and UNG. J Exp Med 202: 561-568.
14. Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, et al. (2007) APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med 204: 3017-3026.
15. Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J, (2007) Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J Immunol 179: 6064-6071.
16. Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, et al. (2003) Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat Immunol 4: 1023-1028.
17. Catalan N, Selz F, Imai K, Revy P, Fischer A, et al. (2003) The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region. J Immunol 171: 2504-2509.
18. Peron S, Metin A, Gardes P, Alyanakian MA, Sheridan E, et al. (2008) Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination. J Exp Med 205: 2465-2472.
19. Longerich S, Meira L, Shah D, Samson LD, Storb U, (2007) Alkyladenine DNA glycosylase (AAG) in somatic hypermutation and class switch recombination. DNA Repair (Amst).
20. Chan MK, Ocampo-Hafalla MT, Vartanian V, Jaruga P, Kirkali G, et al. (2009) Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA Repair (Amst) 8: 786-794.
21. Tokuyama H, Tokuyama Y, (1999) The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching. Cell Immunol 192: 41-47.