메뉴 건너뛰기




Volumn 9, Issue 5, 2012, Pages 776-781

Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide

Author keywords

Drug induced QT interval shortening; Proarrhythmia; Rufinamide; Short QT syndrome; sudden cardiac death; SUDEP

Indexed keywords

ETIRACETAM; LAMOTRIGINE; RUFINAMIDE; VALPROIC ACID;

EID: 84859948014     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.01.006     Document Type: Article
Times cited : (48)

References (45)
  • 5
    • 84655160739 scopus 로고    scopus 로고
    • Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)
    • Templin C, Ghadri JR, Rougier JS, et al. Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). Eur Heart J 2011;32:1077-1088.
    • (2011) Eur Heart J , vol.32 , pp. 1077-1088
    • Templin, C.1    Ghadri, J.R.2    Rougier, J.S.3
  • 6
    • 79960920517 scopus 로고    scopus 로고
    • Long-term follow-up of patients with short QT syndrome
    • Giustetto C, Schimpf R, Mazzanti A, et al. Long-term follow-up of patients with short QT syndrome. J Am Coll Cardiol 2011;58:587-595.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 587-595
    • Giustetto, C.1    Schimpf, R.2    Mazzanti, A.3
  • 7
    • 36448981876 scopus 로고
    • Significance of QT prolongation in the electrocardiogram: Based on the study of 168 cases
    • Bellet S, Finkelstein D. Significance of QT prolongation in the electrocardiogram: based on the study of 168 cases. Am J Med Sci 1951;222:263-278.
    • (1951) Am J Med Sci , vol.222 , pp. 263-278
    • Bellet, S.1    Finkelstein, D.2
  • 9
    • 27244456179 scopus 로고    scopus 로고
    • International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice
    • Food and Drug Administration, HHS
    • Food and Drug Administration, HHS. International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice. Fed Regist 2005;70:61134-61135.
    • (2005) Fed Regist , vol.70 , pp. 61134-61135
  • 10
    • 74549126556 scopus 로고    scopus 로고
    • Drug-induced QT interval shortening: Potential harbinger of proarrhythmia and regulatory perspectives
    • Shah RR. Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives. Br J Pharmacol 2010;159:58-69.
    • (2010) Br J Pharmacol , vol.159 , pp. 58-69
    • Shah, R.R.1
  • 11
    • 33845624280 scopus 로고    scopus 로고
    • Is acquired short QT due to digitalis intoxication responsible for malignant venticular arrhythmias?
    • DOI 10.1016/j.jelectrocard.2006.07.003, PII S0022073606001464
    • Garberoglio L, Giustetto C, Wolpert C, Gaita F. Is acquired short QT due to digitalis intoxication responsible for malignant ventricular arrhythmias? J Electrocardiol 2007;40:43-46. (Pubitemid 44958601)
    • (2007) Journal of Electrocardiology , vol.40 , Issue.1 , pp. 43-46
    • Garberoglio, L.1    Giustetto, C.2    Wolpert, C.3    Gaita, F.4
  • 12
    • 33749829255 scopus 로고    scopus 로고
    • The effect of rufinamide concentration on the QT interval in healthy subjects treated during 18 days with multiple ascending doses: A population PKPD analysis
    • Abstract A785
    • Marchand M, Critchley D, Nagy C, Fuseau E. The effect of rufinamide concentration on the QT interval in healthy subjects treated during 18 days with multiple ascending doses: a population PKPD analysis. In: Annual Meeting of the Population Approach Group in Europe; 2005. Abstract A785.
    • Annual Meeting of the Population Approach Group in Europe; 2005
    • Marchand, M.1    Critchley, D.2    Nagy, C.3    Fuseau, E.4
  • 13
    • 84873746225 scopus 로고    scopus 로고
    • Available at: Accessed August 15, 2011
    • European Medicines Agency. Inovelon® (rufinamide) product information; 2009. Available at: http://wwwemaeuropaeu/ema/indexjsp?curl=pages/ medicines/human/medicines/000660/human-med-000837jsp&murl=menus/medicines/ medicinesjsp&mid=WC0b01ac058001d124. Accessed August 15, 2011.
    • (2009) Inovelon® (Rufinamide) Product Information
  • 14
    • 79953220728 scopus 로고    scopus 로고
    • Serum concentrations of rufinamide in children and adults with epilepsy: The influence of dose, age, and comedication
    • May TW, Boor R, Rambeck B, et al. Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication. Ther Drug Monit 2011;33:214-221.
    • (2011) Ther Drug Monit , vol.33 , pp. 214-221
    • May, T.W.1    Boor, R.2    Rambeck, B.3
  • 15
    • 46349102469 scopus 로고    scopus 로고
    • Accurate electrocardiographic assessment of the QT interval: Teach the tangent
    • Postema PG, De Jong JS, Van der Bilt IA, Wilde AA. Accurate electrocardiographic assessment of the QT interval: teach the tangent. Heart Rhythm 2008;5:1015-1018.
    • (2008) Heart Rhythm , vol.5 , pp. 1015-1018
    • Postema, P.G.1    De Jong, J.S.2    Van Der Bilt, I.A.3    Wilde, A.A.4
  • 16
    • 0033379061 scopus 로고    scopus 로고
    • Transmural dispersion of repolarization and arrhythmogenicity: The Brugada syndrome versus the long QT syndrome
    • Antzelevitch C, Yan GX, Shimizu W. Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome. J Electrocardiol 1999;32:158-165. (Pubitemid 30100122)
    • (1999) Journal of Electrocardiology , vol.32 , Issue.SUPPL. , pp. 158-165
    • Antzelevitch, C.1    Yan, G.-X.2    Shimizu, W.3
  • 17
    • 0025797107 scopus 로고
    • Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system
    • Kenneback G, Bergfeldt L, Vallin H, Tomson T, Edhag O. Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system. Am Heart J 1991;121:1421-1429.
    • (1991) Am Heart J , vol.121 , pp. 1421-1429
    • Kenneback, G.1    Bergfeldt, L.2    Vallin, H.3    Tomson, T.4    Edhag, O.5
  • 18
    • 0025735295 scopus 로고
    • Severe oral phenytoin overdose does not cause cardiovascular morbidity
    • Wyte CD, Berk WA. Severe oral phenytoin overdose does not cause cardiovascular morbidity. Ann Emerg Med 1991;20:508-512.
    • (1991) Ann Emerg Med , vol.20 , pp. 508-512
    • Wyte, C.D.1    Berk, W.A.2
  • 19
    • 0018894544 scopus 로고
    • Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression
    • DeSilvey DL, Moss AJ. Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression. Ann Intern Med 1980;93:53-54. (Pubitemid 10072003)
    • (1980) Annals of Internal Medicine , vol.93 , Issue.1 I , pp. 53-54
    • DeSilvey, D.L.1    Moss, A.J.2
  • 20
    • 77955298453 scopus 로고    scopus 로고
    • Adjunctive rufinamide in Lennox-Gastaut syndrome: A long-term, open-label extension study
    • Kluger G, Glauser T, Krauss G, et al. Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study. Acta Neurol Scand 2010;122:202-208.
    • (2010) Acta Neurol Scand , vol.122 , pp. 202-208
    • Kluger, G.1    Glauser, T.2    Krauss, G.3
  • 22
    • 85129694326 scopus 로고    scopus 로고
    • Rufinamide: A novel broad-spectrum antiepileptic drug
    • Wheless JW, Vazquez B. Rufinamide: a novel broad-spectrum antiepileptic drug. Epilepsy Curr 2010;10:1-106.
    • (2010) Epilepsy Curr , vol.10 , pp. 1-106
    • Wheless, J.W.1    Vazquez, B.2
  • 23
    • 84873746381 scopus 로고    scopus 로고
    • Available at: Accessed December 18, 2011
    • European Medicines Agency. Inovelon® (rufinamide) scientific information; 2007. Available at: http://wwwemaeuropaeu/docs/en-GB/document- library/EPARScientific-Discussion/human/000660/WC500032940pdf. Accessed December 18, 2011.
    • (2007) Inovelon® (Rufinamide) Scientific Information
  • 24
    • 58149475094 scopus 로고    scopus 로고
    • Drug induced shortening of the QT/QTc interval: An emerging safety issue warranting further modelling and evaluation in drug research and development?
    • Holbrook M, Malik M, Shah RR, Valentin JP. Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development? J Pharmacol Toxicol Methods 2009;59:21-28.
    • (2009) J Pharmacol Toxicol Methods , vol.59 , pp. 21-28
    • Holbrook, M.1    Malik, M.2    Shah, R.R.3    Valentin, J.P.4
  • 25
    • 80053900545 scopus 로고    scopus 로고
    • QT-interval shortening in spontaneous reports submitted to the FDA: The need for consensus
    • Raschi E, Poluzzi E, Koci A, Boriani G, De Ponti F. QT-interval shortening in spontaneous reports submitted to the FDA: the need for consensus. Br J Clin Pharmacol 2011;72:839-841.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 839-841
    • Raschi, E.1    Poluzzi, E.2    Koci, A.3    Boriani, G.4    De Ponti, F.5
  • 26
    • 79952118531 scopus 로고    scopus 로고
    • Drug-induced QT interval shortening: An emerging component in integrated assessment of cardiac safety of drugs
    • Shah RR, Bjerregaard P, Gussak I. Drug-induced QT interval shortening: an emerging component in integrated assessment of cardiac safety of drugs. J Electrocardiol 2010;43:386-389.
    • (2010) J Electrocardiol , vol.43 , pp. 386-389
    • Shah, R.R.1    Bjerregaard, P.2    Gussak, I.3
  • 27
    • 49549113387 scopus 로고    scopus 로고
    • Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects
    • Dixon R, Job S, Oliver R, et al. Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects. Br J Clin Pharmacol 2008;66:396-404.
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 396-404
    • Dixon, R.1    Job, S.2    Oliver, R.3
  • 28
    • 33846885882 scopus 로고    scopus 로고
    • Lamotrigine in idiopathic epilepsy - Increased risk of cardiac death?
    • DOI 10.1111/j.1600-0404.2006.00730.x
    • Aurlien D, Tauboll E, Gjerstad L. Lamotrigine in idiopathic epilepsy-increased risk of cardiac death? Acta Neurol Scand 2007;115:199-203. (Pubitemid 46219214)
    • (2007) Acta Neurologica Scandinavica , vol.115 , Issue.3 , pp. 199-203
    • Aurlien, D.1    Tauboll, E.2    Gjerstad, L.3
  • 29
    • 41349107220 scopus 로고    scopus 로고
    • Sudden cardiac death secondary to antidepressant and antipsychotic drugs
    • DOI 10.1517/14740338.7.2.181
    • Sicouri S, Antzelevitch C. Sudden cardiac death secondary to antidepressant and antipsychotic drugs. Expert Opin Drug Saf 2008;7:181-194. (Pubitemid 351447701)
    • (2008) Expert Opinion on Drug Safety , vol.7 , Issue.2 , pp. 181-194
    • Sicouri, S.1    Antzelevitch, C.2
  • 30
    • 84873748293 scopus 로고    scopus 로고
    • Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants
    • Minoura Y, JM DID, Barajas-Martinez H, et al. Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. J Cardiovasc Electrophysiol 2011.
    • (2011) J Cardiovasc Electrophysiol
    • Minoura, Y.1    Did, J.M.2    Barajas-Martinez, H.3
  • 32
    • 64649104751 scopus 로고    scopus 로고
    • Prevalence of long and short QT in a young population of 41,767 predominantly male Swiss conscripts
    • Kobza R, Roos M, Niggli B, et al. Prevalence of long and short QT in a young population of 41,767 predominantly male Swiss conscripts. Heart Rhythm 2009;6:652-657.
    • (2009) Heart Rhythm , vol.6 , pp. 652-657
    • Kobza, R.1    Roos, M.2    Niggli, B.3
  • 33
    • 64649085718 scopus 로고    scopus 로고
    • The QT interval: Too long, too short or just right
    • Viskin S. The QT interval: too long, too short or just right. Heart Rhythm 2009;6:711-715.
    • (2009) Heart Rhythm , vol.6 , pp. 711-715
    • Viskin, S.1
  • 35
    • 83255185241 scopus 로고    scopus 로고
    • Sudden unexpected death in epilepsy
    • Shorvon S, Tomson T. Sudden unexpected death in epilepsy. Lancet 2011.
    • (2011) Lancet
    • Shorvon, S.1    Tomson, T.2
  • 37
    • 1342345285 scopus 로고    scopus 로고
    • The potential for QT prolongation by antiepileptic drugs in children
    • DOI 10.1016/S0887-8994(03)00405-3
    • Kwon S, Lee S, Hyun M, et al. The potential for QT prolongation by antiepileptic drugs in children. Pediatr Neurol 2004;30:99-101. (Pubitemid 38249342)
    • (2004) Pediatric Neurology , vol.30 , Issue.2 , pp. 99-101
    • Kwon, S.1    Lee, S.2    Hyun, M.3    Choe, B.-H.4    Kim, Y.5    Park, W.6    Cho, Y.7
  • 38
    • 79251560652 scopus 로고    scopus 로고
    • Post-mortem review and genetic analysis of sudden unexpected death in epilepsy (SUDEP) cases
    • Tu E, Bagnall RD, Duflou J, Semsarian C. Post-mortem review and genetic analysis of sudden unexpected death in epilepsy (SUDEP) cases. Brain Pathol 2011;21:201-208.
    • (2011) Brain Pathol , vol.21 , pp. 201-208
    • Tu, E.1    Bagnall, R.D.2    Duflou, J.3    Semsarian, C.4
  • 39
    • 80054679391 scopus 로고    scopus 로고
    • Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases
    • Tu E, Waterhouse L, Duflou J, Bagnall RD, Semsarian C. Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases. Brain Pathol 2011;21:692-698.
    • (2011) Brain Pathol , vol.21 , pp. 692-698
    • Tu, E.1    Waterhouse, L.2    Duflou, J.3    Bagnall, R.D.4    Semsarian, C.5
  • 41
    • 77954419075 scopus 로고    scopus 로고
    • Cardiac channel molecular autopsy for sudden unexpected death in epilepsy
    • Johnson JN, Tester DJ, Bass NE, Ackerman MJ. Cardiac channel molecular autopsy for sudden unexpected death in epilepsy. J Child Neurol 2010;25:916-921.
    • (2010) J Child Neurol , vol.25 , pp. 916-921
    • Johnson, J.N.1    Tester, D.J.2    Bass, N.E.3    Ackerman, M.J.4
  • 42
    • 45749100010 scopus 로고    scopus 로고
    • 2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice
    • 2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest 2008;118:2230-2245.
    • (2008) J Clin Invest , vol.118 , pp. 2230-2245
    • Lehnart, S.E.1    Mongillo, M.2    Bellinger, A.3
  • 43
    • 60649106155 scopus 로고    scopus 로고
    • New SCN5A mutation in a SUDEP victim with idiopathic epilepsy
    • Aurlien D, Leren TP, Tauboll E, Gjerstad L. New SCN5A mutation in a SUDEP victim with idiopathic epilepsy. Seizure 2009;18:158-160.
    • (2009) Seizure , vol.18 , pp. 158-160
    • Aurlien, D.1    Leren, T.P.2    Tauboll, E.3    Gjerstad, L.4
  • 44
    • 76349116683 scopus 로고    scopus 로고
    • Enhanced QT shortening and persistent tachycardia after generalized seizures
    • Surges R, Scott CA, Walker MC. Enhanced QT shortening and persistent tachycardia after generalized seizures. Neurology 2010;74:421-426.
    • (2010) Neurology , vol.74 , pp. 421-426
    • Surges, R.1    Scott, C.A.2    Walker, M.C.3
  • 45
    • 79958824035 scopus 로고    scopus 로고
    • Combined analysis of risk factors for SUDEP
    • Hesdorffer DC, Tomson T, Benn E, et al. Combined analysis of risk factors for SUDEP. Epilepsia 2011;52:1150-1159.
    • (2011) Epilepsia , vol.52 , pp. 1150-1159
    • Hesdorffer, D.C.1    Tomson, T.2    Benn, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.