Search for clastogenic factors in the plasma of locally irradiated individuals

Radiation Research

Volumn 177, Issue 3, 2012, Pages 298-306

  Lindholm, C ^a   Acheva, A ^a,b   Koivistoinen, A ^a   Perl, M ^a   Heinvaara, S ^a   Jahns, J ^c   Salomaa, S ^a   Hildebrandt, G ^c,d  

^a STUK RADIATION AND NUCLEAR SAFETY AUTHORITY   (Finland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLASTOGEN; GAMMA HISTONE H2AX; HISTONE H2AX; IRIDIUM 192; NONSTEROID ANTIINFLAMMATORY AGENT; STEROID; UNCLASSIFIED DRUG; H2AFX PROTEIN, HUMAN; HISTONE; MUTAGENIC AGENT;

ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; BLOOD LEVEL; BLOOD SAMPLING; BRACHYTHERAPY; CANCER RADIOTHERAPY; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; EPICONDYLOPATHIA HUMERI; FEMALE; GENOTOXICITY; HEEL SPUR; HUMAN; KINETICS; KNEE OSTEOARTHRITIS; LYMPHOCYTE; MALE; MICRONUCLEUS TEST; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; TENDINITIS; CHROMATID; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; MIDDLE AGED; NUCLEAR ACCIDENT; PLASMA; STATISTICAL MODEL;

ADULT; AGED; AGED, 80 AND OVER; CHROMATIDS; CHROMOSOME ABERRATIONS; FEMALE; HISTONES; HUMANS; LOGISTIC MODELS; LYMPHOCYTES; MALE; MIDDLE AGED; MUTAGENS; PLASMA; RADIOACTIVE HAZARD RELEASE; YOUNG ADULT;

EID: 84859935663     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2721.1     Document Type: Article

References (30)

1. Parsons WB, Watkins CH, Pease GL, Childs DS. Changes in sternal bone marrow following roentgen-ray therapy to the spleen in chronic granulocytic leukaemia. Cancer 1954; 7:179-89.
2. Souto J. Tumour development in the rat induced by the blood of irradiated animals. Nature 1962; 195:1317-8.
3. Goh K, Sumner H. Breaks in normal human chromosomes: are they induced by a transferable substance in the plasma of persons exposed to total-body irradiation? Radiat Res 1968; 35:171-81.
4. Hollowell JG Jr, Littlefield LG. Chromosome damage induced by plasma of X-rayed patients: An indirect effect of X-ray. Proc Soc Exp Biol Med 1968; 129:240-4.
5. Littlefield LG, Hollowell JG Jr, Pool WH Jr. Chromosomal aberrations induced by plasma from irradiated patients: An indirect effect of X radiation. Further observations and studies of a control population. Radiology 1969; 93:879-86.
6. Pant GS, Kamada N. Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals. Hiroshima J Med Sci 1977; 26:240-4.
7. Emerit I, Levy A, Cernjavski L, Arutyunyan R, Oganesyan N, Pogosian A, et al. Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor. J Cancer Res Clin Oncol 1994; 120:558-61. (Pubitemid 24246575)
8. Emerit I, Quastel M, Goldsmith J, Merkin L, Levy A, Cernjavski L, et al. Clastogenic factors in the plasma of children exposed at Chernobyl. Mutat Res 1997; 373:47-54. (Pubitemid 27037970)
9. Emerit I. Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radic Biol Med 1994; 16:99-109.
10. Fuchs J, Oelke N, Imhof M, Ochsendorf Schöfer H, Oromek G, Alaoui-Youssefi A, et al. Multiparameter analysis of clastogenic factors, pro-oxidant cytokines, and inflammatory markers in HIV-l-infected patients with asymptomatic disease, opportunistic infections, and malignancies. Mol Med 1998; 4:333-43. (Pubitemid 28361657)
11. Shaham M, Becker Y, Cohen MM. A diffusable clastogenic factor in ataxia telangiectasia. Cytogenet Cell Genet 1980; 27:155-61. (Pubitemid 10124410)
12. Shaham M, Becker Y. The ataxia telangiectasia clastogenic factor is a low molecular weight peptide. Hum Genet 1981; 58:422-4. (Pubitemid 11027649)
13. Emerit I, Levy A, Calzone R, Zatterale A. Transferable clastogenic activity in plasma from patients with Fanconi anemia. Hum Genet 1995; 96:14-20.
14. Emerit I, Oganesian, N. Sarkisian T, Arutyunyan R, Pogosian A, Asrian K, et al. Clastogenic factors in the plasma of Chernobyl accident recovery workers: Anticlastogenic effect of Ginkgo biloba extract. Radiat Res 1995; 144:198-205.
15. Emerit I, Garban F, Vassy J, Levy Filipe P, Freitas J. Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase. Proc Natl Acad Sci USA 1996; 93:12799-804. (Pubitemid 26382723)
16. Emerit I, Oganesian N, Arutyunian R, Pogossian A, Sarkisian, R, Cernjavski L, et al. Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antiox-idant plant phenols, vitamins and oligoelements. Mutat Res 1997; 377:239-46. (Pubitemid 27290610)
17. Emerit I, Khan SH, Esterbau H. Hydroxynonenal, a component of clastogenic factors? Free Radic Biol Med 1991; 10:371-7.
18. Auclair C, Alain G, Levy A, Emerit I. Clastogenic inosine nucleotide as components of the chromosome breakage factor in scleroderma patients. Arch Biochem Biophys 1990; 278:238-44. (Pubitemid 20121896)
19. Rogakou E, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-15. (Pubitemid 29430435)
20. Ismail HI, Wadhra TI, Hammarsten O. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res 2007; 35:1-10.
21. Lindholm C, Salomaa S, Tekkel M, Paile W, Koivistoinen A, Ilus T, et al. Biodosimetry after accidental radiation exposure by conventional chromosome analysis and FISH. Int J Radiat Biol 1996; 70:647-56.
22. Kato TA, Nagasawa H, Weil MM, Little JB, Bedford JS. Levels of c-H2AX foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two AT families and in another apparently normal individual. Radiat Res 2006; 166:443-53. (Pubitemid 44353427)
23. Suzuki M, Suzuki K, Kodama S, Watanabe M. Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation. Radiat Res 2006; 165:269-76.
24. Paillole N, Voisin P. Is micronuclei yield variability a problem for overexposure dose assessment to ionizing radiation? Mutat Res 1998; 413:47-56. (Pubitemid 28218246)
25. Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E. HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte culture. Mutat Res 2003; 534:65-75. (Pubitemid 36015839)
26. Ballardin M, Gemignani F, Bodei L, Mariani G, Ferdeghini M, Rossi AM, et al. Formation of micronuclei and of clastogenic factor(s) in patients receiving therapeutic doses of iodine-131. Mutat Res 2002; 514:77-85. (Pubitemid 34114081)
27. Trott KR, Kamprad F. Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiother Oncol 1999; 51:197-203. (Pubitemid 29305702)
28. Rödel F, Keilholz L, Herrmann M, Sauer R, Hildebrandt G. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int J Radiat Biol 2007; 83:357-66. (Pubitemid 46752383)
29. Emerit I. Clastogenic factors as potential biomarkers of increased superoxide production. Biomark Insights 2007; 2:429-38.
30. Marozik P, Mothersill C, Seymour CB, Mosse I, Melnov S. Bystander effects induced by serum from survivors of the Chernobyl accident. Exp Hematol 2007; 35:55-63. (Pubitemid 46427998)