Reply to Nugue and Wion: Targeting cancer stem cells' hypoxic core

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 16, 2012, Pages

  Conley, Sarah J ^a   Wicha, Max S ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECHINOMYCIN; HYPOXIA INDUCIBLE FACTOR 1; REACTIVE OXYGEN METABOLITE;

ACUTE GRANULOCYTIC LEUKEMIA; ANGIOGENESIS; BREAST CANCER; CANCER STEM CELL; CELL HYPOXIA; CELL POPULATION; CELL STRESS; DNA DAMAGE CHECKPOINT; GLIOMA CELL; LETTER; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION;

EID: 84859932405     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203321109     Document Type: Letter

References (6)

1. Conley SJ, et al. (2012) Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci USA 109:2784-2789.
2. Nugue G, Wion D (2012) Angiogenesis and the tumor space-time continuum. Proc Natl Acad Sci USA 109:E914.
3. Rasheed ZA, Kowalski J, Smith BD, Matsui W (2011) Concise review: Emerging concepts in clinical targeting of cancer stem cells. Stem Cells 29:883-887.
4. Li Z, et al. (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501-513.
5. Wang Y, Liu Y, Malek SN, Zheng P, Liu Y (2011) Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8:399-411.
6. Diehn M, et al. (2009) Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458:780-783.