Decreased mucosal expression of intestinal alkaline phosphatase in children with coeliac disease

Virchows Archiv

Volumn 460, Issue 2, 2012, Pages 157-161

  Molnár, Kriszta ^a   Vannay, Ádám ^a   Sziksz, Erna ^a   Bánki, Nóra Fanni ^b   Győrffy, Hajnalka ^a   Arató, András ^a   Dezsőfi, Antal ^a   Veres, Gabor ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Children; Coeliac disease; Duodenal biopsy; Intestinal alkaline phosphatase; Toll like receptor

Indexed keywords

ALKALINE PHOSPHATASE; MESSENGER RNA; TOLL LIKE RECEPTOR; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 4;

ARTICLE; CELIAC DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DUODENUM MUCOSA; FEMALE; GLUTEN FREE DIET; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; STAINING; WESTERN BLOTTING; ADOLESCENT; BIOSYNTHESIS; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; INFANT; INTESTINE MUCOSA; REAL TIME POLYMERASE CHAIN REACTION;

ADOLESCENT; ALKALINE PHOSPHATASE; BLOTTING, WESTERN; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INFANT; INTESTINAL MUCOSA; MALE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4;

EID: 84859932272     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1188-5     Document Type: Article

References (22)

1. Maynard CL, Weaver CT (2011) Immunology: context is key in the gut. Nature 471:169-170
2. Dickson BC, Streutker CJ, Chetty R (2006) Coeliac disease: an update for pathologists. J Clin Pathol 59:1008-1016 (Pubitemid 44570322)
3. Ensari A (2010) Gluten-sensitive enteropathy (celiac disease): controversies in diagnosis and classification. Arch Pathol Lab Med 134:826-836
4. Cario E (2008) Barrier-protective function of intestinal epithelial Toll-like receptor 2. Mucosal Immunol 1(Suppl 1):S62-S66
5. Abreu M, Fukata M, Arditi M (2005) TLR signaling in the gut in health and disease. J Immunol 174:4453-4460
6. Triantafilou M, Triantafilou K (2002) Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol 23:301-304 (Pubitemid 34628773)
7. Baumgart D, Thomas S, Przesdzing I, Metzke D, Bielecki C, Lehmann S, Lehnardt S, Dörffel Y, Sturm A, Scheffold A, Schmitz J, Radbruch A (2009) Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease. Clin Exp Immunol 157:423-436
8. Szebeni B, Veres G, Dezsofi A, Rusai K, Vannay A, Bokodi G, Vásárhelyi B, Korponay-Szabó I, Tulassay T, Arató A (2007) Increased mucosal expression of Toll-like receptor (TLR)2 and TLR4 in coeliac disease. J Pediatr Gastroenterol Nutr 45:187-193 (Pubitemid 47220526)
9. Cseh Á, Vásárhelyi B, Szalay B, Molnár K, Nagy-Szakál D, Treszl A, Vannay Á, Arató A, Tulassay T, Veres G (2011) Immune phenotype of children with newly diagnosed and gluten-free diettreated celiac disease. Dig Dis Sci 56:792-798
10. Lallès JP (2010) Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet. Nutr Rev 68:323-332
11. Bates J, Akerlund J, Mittge E, Guillemin K (2007) Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe 2:371-382 (Pubitemid 350215326)
12. Goldberg RF, Austen WG, Zhang X, Munene G, Mostafa G, Biswas S, McCormack M, Eberlin KR, Nguyen JT, Tatlidede HS, Warren HS, Narisawa S, Millán JL, Hodin RA (2008) Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A 105:3551-3556 (Pubitemid 351723590)
13. Geddes K, Philpott D (2008) A new role for intestinal alkaline phosphatase in gut barrier maintenance. Gastroenterology 135:8-12 (Pubitemid 351899043)
14. Tuin A, Poelstra K, de Jager-Krikken A, Bok L, Raaben W, Velders M, Dijkstra G (2009) Role of alkaline phosphatase in colitis in man and rats. Gut 58:379-387
15. Lukas M, Drastich P, Konecny M, Gionchetti P, Urban O, Cantoni F, Bortlik M, Duricova D, Bulitta M (2010) Exogenous alkaline phosphatase for the treatment of patients with moderate to severe ulcerative colitis. Inflamm Bowel Dis 16:1180-1186
16. Prasad K, Thapa B, Nain C, Sharma A, Singh K (2008) Brush border enzyme activities in relation to histological lesion in pediatric celiac disease. J Gastroenterol Hepatol 23:e348-e352
17. Ribes-Koninckx C, Mearin M, Korponay-Szabó I, Shamir R, Husby S, Ventura A, Branski D, Catassi C, Koletzko S, Mäki M, Troncone R, Zimmer K, The ESPGHAN Working Group on Coeliac Disease Diagnosis (2012) Coeliac disease diagnosis: espghan 1990 Criteria or need for a change? Results of a questionnaire. J Pediatr Gastroenterol Nutr 54(1):15-19
18. Meijer JW, Wahab PJ, Mulder CJ (2003) Small intestinal biopsies in celiac disease: duodenal or jejunal? Virchows Arch 442:124-128 (Pubitemid 36337659)
19. Dalgic B, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A, Baris Z, TurkishCeliac Study Group (2011) Prevalence of celiac disease in healthy Turkish school children. Am J Gastroenterol 106:1512-1517
20. Gorgun J, Portyanko A, Marakhouski Y, Cherstvoy E (2009) Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study. Virchows Arch 455:363-373
21. Wahab PJ, Meijer JW, Mulder CJ (2002) Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. Am J Clin Pathol 118:459-463 (Pubitemid 37046345)
22. Szakál DN, Gyorffy H, Arató A, Cseh A, Molnár K, Papp M, Dezsofi A, Veres G (2010) Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch 456:245-250