Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: Antimicrobial peptide and protein responses

Pediatric Research

Volumn 71, Issue 5, 2012, Pages 546-551

  Underwood, Mark A ^a   Kananurak, Anchasa ^b   Coursodon, Christine F ^c   Adkins Reick, Camille K ^c   Chu, Hiutung ^b   Bennett, Stephen H ^a   Wehkamp, Jan ^b,d   Castillo, Patricia A ^b   Leonard, Brian C ^b   Tancredi, Daniel J ^a   Sherman, Michael P ^a,e   Dvorak, Bohuslav ^c   Bevins, Charles L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^e University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOZYME; MESSENGER RNA; PHOSPHOLIPASE A2; POLYPEPTIDE ANTIBIOTIC AGENT; PROBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPHYXIA; BIFIDOBACTERIUM BIFIDUM; CHILD DEVELOPMENT; COLD STRESS; CONTROLLED STUDY; GENE EXPRESSION; HISTOLOGY; ILEUM; INTESTINE FLORA; MOUSE; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; ONTOGENY; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFECTIVE AGENTS; BASE SEQUENCE; BIFIDOBACTERIUM; DISEASE MODELS, ANIMAL; DNA PRIMERS; ENTEROCOLITIS, NECROTIZING; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; PEPTIDES; POLYMERASE CHAIN REACTION; PROBIOTICS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84859906323     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.11     Document Type: Article

References (41)

1. Eichenwald EC, Stark AR. Management and outcomes of very low birth weight. N Engl J Med 2008;358:1700-11.
2. Henry MC, Moss RL. Necrotizing enterocolitis. Annu Rev Med 2009;60:111-24.
3. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med 2011;364:255-64.
4. Morowitz MJ, Poroyko V, Caplan M, Alverdy J, Liu DC. Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis. Pediatrics 2010;125:777-85.
5. Guthmann F, Kluthe C, Bührer C. Probiotics for prevention of necrotising enterocolitis: an updated meta-analysis. Klin Padiatr 2010;222:284-90.
6. Caplan MS, Miller-Catchpole R, Kaup S, et al. Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Gastroenterology 1999;117:577-83. (Pubitemid 29409243)
7. Khailova L, Dvorak K, Arganbright KM, et al. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 2009;297:G940-9.
8. Khailova L, Mount Patrick SK, Arganbright KM, Halpern MD, Kinouchi T, Dvorak B. Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 2010;299:G1118-27.
9. Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 2011;9:356-68.
10. Salzman NH, Underwood MA, Bevins CL. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 2007;19:70-83. (Pubitemid 46824070)
11. Mallow EB, Harris A, Salzman N, et al. Human enteric defensins. Gene structure and developmental expression. J Biol Chem 1996;271:4038-45.
12. Salzman NH, Polin RA, Harris MC, et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res 1998;44:20-6. (Pubitemid 28303439)
13. Coutinho HB, da Mota HC, Coutinho VB, et al. Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitis. J Clin Pathol 1998;51:512-14. (Pubitemid 28375030)
14. Puiman PJ, Burger-Van Paassen N, Schaart MW, et al. Paneth cell hyperplasia and metaplasia in necrotizing enterocolitis. Pediatr Res 2011;69:217-23.
15. Termé S, Tollin M, Olsson B, Svenberg T, Agerberth B, Gudmundsson GH. Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptides. Cell Mol Life Sci 2003;60:536-49. (Pubitemid 36459532)
16. Jia HP, Mills JN, Barahmand-Pour F, et al. Molecular cloning and characterization of rat genes encoding homologues of human β-defensins. Infect Immun 1999;67:4827-33. (Pubitemid 29400470)
17. Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 2006;313:1126-30. (Pubitemid 44300239)
18. Iovanna JL, Keim V, Bosshard A, et al. PAP, a pancreatic secretory protein induced during acute pancreatitis, is expressed in rat intestine. Am J Physiol 1993;265:G611-8. (Pubitemid 23325984)
19. Sharma R, Tepas JJ 3rd. Microecology, intestinal epithelial barrier and necrotizing enterocolitis. Pediatr Surg Int 2010;26:11-21.
20. Szajewska H. Probiotics and prebiotics in preterm infants: where are we? Where are we going? Early Hum Dev 2010;86 Suppl 1:81-6.
21. Sherman MP. New concepts of microbial translocation in the neonatal intestine: mechanisms and prevention. Clin Perinatol 2010;37:565-79.
22. Fernandez MI, Regnault B, Mulet C, et al. Maturation of paneth cells induces the refractory state of newborn mice to Shigella infection. J Immunol 2008;180:4924-30.
23. Ménard S, Förster V, Lotz M, et al. Developmental switch of intestinal antimicrobial peptide expression. J Exp Med 2008;205:183-93. (Pubitemid 351185725)
24. Bry L, Falk P, Huttner K, Ouellette A, Midtvedt T, Gordon JI. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc Natl Acad Sci USA 1994;91:10335-9. (Pubitemid 24328991)
25. Mukherjee S, Vaishnava S, Hooper LV. Multi-layered regulation of intestinal antimicrobial defense. Cell Mol Life Sci 2008;65:3019-27.
26. Putsep K, Axelsson LG, Boman A, et al. Germ-free and colonized mice generate the same products from enteric prodefensins. J Biol Chem 2000;275:40478-82. (Pubitemid 32064683)
27. DiGiulio DB, Romero R, Kusanovic JP, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010;64:38-57.
28. Underwood MA, Gilbert WM, Sherman MP. Amniotic fluid: not just fetal urine anymore. J Perinatol 2005;25:341-8. (Pubitemid 40645606)
29. Schröder JM, Harder J. Human β-defensin-2. Int J Biochem Cell Biol 1999;31:645-51.
30. Ciccia F, Bombardieri M, Rizzo A, et al. Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation. Rheumatology (Oxford) 2010;49:2076-83.
31. Jäger S, Stange EF, Wehkamp J. Antimicrobial peptides in gastrointestinal inflammation. Int J Inflam 2010;2010:910283.
32. Bevins CL, Stange EF, Wehkamp J. Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. Gut 2009;58:882-3;discussion 883.
33. Schlee M, Harder J, Köten B, Stange EF, Wehkamp J, Fellermann K. Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2. Clin Exp Immunol 2008;151:528-35. (Pubitemid 351160737)
34. Amit-Romach E, Uni Z, Reifen R. Multistep mechanism of probiotic bacterium, the effect on innate immune system. Mol Nutr Food Res 2010;54:277-84.
35. Möndel M, Schroeder BO, Zimmermann K, et al. Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans. Mucosal Immunol 2009;2:166-72.
36. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979;18:5294-9. (Pubitemid 10140274)
37. Clark JA, Doelle SM, Halpern MD, et al. Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol 2006;291:G938-49. (Pubitemid 44772020)
38. Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000;25:169-93.
39. Wehkamp J, Chu H, Shen B, et al. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett 2006;580:5344-50. (Pubitemid 44419568)
40. Dvorak B, Halpern MD, Holubec H, et al. Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 2002;282:G156-64. (Pubitemid 34650110)
41. Moore KS, Bevins CL, Tomassini N, et al. A novel peptide-producing cell in Xenopus: multinucleated gastric mucosal cell strikingly similar to the granular gland of the skin. J Histochem Cytochem 1992;40: 367-78.