Lys656Asn polymorphism of leptin receptor, leptin levels and insulin resistance in patients with non alcoholic fatty liver disease

European Review for Medical and Pharmacological Sciences

Volumn 16, Issue 3, 2012, Pages 335-341

  Aller, R ^a   De Luis, D A ^b   Izaola, O ^b   Gonzalez Sagrado M ^b   Conde, R ^b   Pacheco, D ^b   Velasco, M C ^b   Ovalle, H F ^b  

^a HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Biopsy; Insulin resistance; Leptin; Lys656Asn polymorphism of leptin receptor

Indexed keywords

ASPARAGINE; GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; LYSINE;

ADULT; BIOCHEMISTRY; BODY FAT; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENOTYPE; HISTOLOGY; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PROTEIN POLYMORPHISM; REVIEW; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WEIGHT; WILD TYPE;

ADULT; ANTHROPOMETRY; BIOPSY; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; DNA; FATTY LIVER; FEMALE; GENOTYPE; HUMANS; INSULIN RESISTANCE; LEPTIN; LIVER; MALE; MIDDLE AGED; OVERWEIGHT; POLYMORPHISM, GENETIC; RECEPTORS, LEPTIN; RISK FACTORS; SAMPLE SIZE; TRIGLYCERIDES;

EID: 84859890601     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (33)

1. LUDWIG J, VIGGIANO TR, MCGILL D, OTT BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic Proc 1980;55:434-438. (Pubitemid 10057164)
2. KRAL JG, SCHAFFNER F, PIERSON RN, WANG J. Body fat topography as an independent predictor of fatty liver. Metabolism 1993;42:548-551. (Pubitemid 23141622)
3. ALLER R, DE LUIS DA, FERNANDEZ L, CALLER F, VELAYOS B, OLCOZ JL, IZAOLA O, GONZALEZ SAGRADO M, CONDE R, GONZALEZ JM. Influence of insulin resistance and adipokines in the grade of steatosis of non-alcoholic fatty liver disease. Dig Dis Sci 2008;53:1088-1092. (Pubitemid 351379844)
4. MARCEAU P, BIRON S, HOULD FS, MARCEAU S, SIMARD S, THUNG SN, KRAL JG. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab 1999;84:1513-1517. (Pubitemid 30644245)
5. HUI JM, HODGE A, FARRELL GC, KENCH JG, KRIKETOS A, GEORGE J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 2004;40:46-54. (Pubitemid 38868922)
6. LEE GH, PROENCA R, MONTEZ JM. Abnormal splicing of leptin receptor in diabetic mice. Nature 1996;379:632-635. (Pubitemid 26053452)
7. CLEMENT K, VAISSE C, LAHLOU N. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;329:398-401. (Pubitemid 28168737)
8. HEO M, LEÍBLE RL, BOYER BB, CHENG WK, KOULU M, KARNOVEN MK, PESONEN U, RISSANEN A, LAAKSO M, UUSITUPA MI, CHAGNON Y, BOUCHARD C, DONOHOUE PA, BURNS TL, SHULDINER AR, SILVER K, ANDERSEN RE, PEDERSEN O, ECHWALD S, SØRENSEN TI, BEHN P, PERMUTT MA, JACOBS KB, ELSTON RC, HOFFMAN DJ, ALLISON DB. Pooling analisis of genetic data: The assocation of leptin receptor (LEPR) polymorphisms with variables related to human adiposity. Genetics 2001;159:1163-1178. (Pubitemid 34033458)
9. KIEFFER TJ, HELLER RS, HABENER J F. Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun 1996:224:522-527. (Pubitemid 26268219)
10. LU H, SUN J, SUN L, SHU X, XU Y, XIE D. Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with NAFLD in China. J Gastroenterol Hepatol 2009;24:228-232.
11. CHEN SH, LI YM, JIANG LL, YU CH. Evaluation of leptin receptor Lys109Arg polymorphism in patients with non-alcoholic fatty liver disease. Zhonghua Gan Zang Bing Za Zhi 2006;6:453-455.
12. BRUNT EM. Non alcoholic steatohepatitis: definition and pathology. Semin Liver Dis 2001;21:3-16. (Pubitemid 32240482)
13. DUART MJ, ARROYO CO, MORENO JL. Validation of a insulin model for the reactions in RIA. Clin Chem Lab Med 2002;40:1161-1167. (Pubitemid 36024452)
14. MATTHEWS DR, HOSKER J P, RUDENSKI AS, NAYLOR BA, TREACHER D F, TURNER RC. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. (Pubitemid 15018832)
15. WAUTERS M, CONSIDINE R, CHAGNON M, MERTENS I, RANKINEN T, BOUCHARD C, VAN GAAL L F. Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women. Obesity Res 2002;10:394-400. (Pubitemid 135688250)
16. DE LUIS DA, GONZALEZ M, ALLER R, IZAOLA O, CONDE R. Influence of Lys565Asn polymorphism of leptin receptor gene on insulin resistance in nondiabetic obese patients. J Diabetes Complications 2008;22:199-204. (Pubitemid 351545844)
17. DE LUIS DA, GONZALEZ SAGRADO M, ALLER R, IZAOLA O, CONDE R. Influence of Lys565Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2. Diabetes Res Clin Pract 2008:81:e9-e11.
18. BERTI L, KELLERER M, CAPP E, HARING H. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a PI3-kinase mediates effect. Diabetologia 1997:40:606-609. (Pubitemid 27186799)
19. CEDDIA R, WILLIAM W, CURI R. Comparing effects of leptin and insulin on glucose metabolis in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation. Int J Obes 1999:23:75-82. (Pubitemid 29008402)
20. KIEFFER TJ, HABENER JF. The adipoinsular axis: effects of leptin on pancreatic beta cells. Am J Physiol Endocrinol Metab 2000:278:E1-E14. (Pubitemid 30101914)
21. MARCHESINI G, BRIZI M, MORSELLI-LABATE A, BIANCHI G, BUGIANESI E, MCCULLOUGH AJ. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999;107:450-454.
22. SANYAL AJ, CAMPBELL SARGENT C, MIRSHASHI F, RIZZO WB, CONTOS MJ, STERLING RK, LUKETIC VA. Non alcoholic steatohepatitis: association of insulin resistance and mitocohondrial abnormalities. Gastroenterology 2001;120:1183-1192. (Pubitemid 32246672)
23. RASHID M, ROBERTS EA. Nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr 2000;30:48-53. (Pubitemid 30349945)
24. CHITTURI S, ABEYGUNASEKERA S, FARRELL GC, HOLMES-WALKER J. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002;73:373-379. (Pubitemid 34106377)
25. VENTURI C, ZOPPINI G, ZAMBONI C, MUGGEO M. Insulin sensivity and hepatic steatosis in obese subjects with normal glucose tolerance. Nutr Metab Cardiovasc Dis 2004:14:200-204. (Pubitemid 39462924)
26. LECLERCQ IA, FARRELL GC, SCHRIEMER R ROBERTSON GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 2002;37:206-213. (Pubitemid 34833082)
27. SAHAI A, MALLADI P, PAN X, PAUL R, MELIN-ALDANA H, GREEN RM, WHITINGTON P F. Obese and diabetic db/db mice develop marked liver fibrosis in a model of non-alcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 2004;287:G1035-G1043. (Pubitemid 39423696)
28. EBIHARA K, KUSAKABE T, HIRATA M, MASUZAKI H, MIYANAGA F, KOBAYASHI N, TANAKA T, CHUSHO H, MIYAZAWA T, HAYASHI T, HOSODA K, OGAWA Y, DEPAOLI AM, FUKUSHIMA M, NAKAO K. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab 2007;92:532-541.
29. LEE JH, CHAN JL, SOURLAS E, RAPTOPOULOS V, MANTZOROS CS. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab 2006;91:2605-2611. (Pubitemid 44024625)
30. SHINTANI M, IKEGAMI H, YAMATO E, KAWAGUCHI Y, FUJISAWA T, NAKAGAWA Y, HAMADA Y, UEDA H, MIKI T, OGIHARA T. A novel micro satellite polymorphism in the human ob gene: a highly polymorphic marker for linkage analysis. Diabetologia 1996;39:1398-1401 (Pubitemid 26356073)
31. LAKKA T, RANKINEN T, WEISNAGEL SJ, CHAGNON YC, LAKKA HM, UKKOLA O, BOULE N. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals. Diabetes 2004;53:1603-1610.
32. ALLER R, DE LUIS DA, FERNADEZ L, CALLE H, VELAYOS B, IZAOLA O, GONZALEZ SAGRADO M, CONDE R, GONZALEZ JM. Influence of Ala 54thr polymorphism of fatty acid binding protein 2 on histological alterations and insulin resistance of non alcoholic fatty liver disease. Eur Rev Med Pharmacol Sci 2009;13:157-162.
33. ALLER R, DE LUIS DA, FERNADEZ L, CALLER F, VELAYOS B, OLCOZ JL, IZAOLA O, GONZALEZ SAGRADO M, CONDE R, GONZALEZ JM. Influence of insulin resistance and adipokines in the grade of steatosis of non-alcoholic fatty liver disease. Dig Dis Sci 2008;53:1088-1092. (Pubitemid 351379844)