Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: Demographic, interpersonal, and intrapersonal factors

Clinical Transplantation

Volumn 26, Issue 2, 2012, Pages 328-335

  Lamba, Sangeeta ^a   Nagurka, Roxanne ^a   Desai, Kunj K ^b   Chun, Shaun J ^a   Holland, Bart ^a   Koneru, Baburao ^b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Adherence; Compliance; Immune suppression; Immune suppressant; Liver transplantation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ADULT; AGED; ARTICLE; DEMOGRAPHY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TREATMENT REFUSAL;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERNAL-EXTERNAL CONTROL; LIVER TRANSPLANTATION; MALE; MEDICATION ADHERENCE; MIDDLE AGED; QUESTIONNAIRES; SOCIAL SUPPORT; SOCIOECONOMIC FACTORS; SUBSTANCE-RELATED DISORDERS; YOUNG ADULT;

EID: 84859868283     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2011.01489.x     Document Type: Article

References (40)

1. Adam R, McMaster P, O'Grady JG et al. Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry. Liver Transpl 2003: 9: 1231.
2. Dew MA, DiMartini AF, De Vito Dabbs A et al. Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 2007: 83: 858.
3. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005: 353: 487.
4. O'Carroll RE, McGregor LM, Swanson V, Masterson G, Hayes PC. Adherence to medication after liver transplantation in Scotland: a pilot study. Liver Transpl 2006: 12: 1862.
5. Cleemput I, Kesteloot K, Vanrenterghem Y, De Geest S. The economic implications of non-adherence after renal transplantation. Pharmacoeconomics 2004: 22: 1217.
6. Haustein SV, McGuire BM, Eckhoff DE et al. Impact of noncompliance and donor/recipient race matching on chronic liver rejection. Transplant Proc 2002: 34: 1497.
7. Dew MA, Dimartini AF. The incidence of nonadherence after organ transplant: ensuring that our efforts at counting really count. Liver Transpl 2006: 12: 1736.
8. DiMartini A, Day N, Dew MA et al. Alcohol use following liver transplantation: a comparison of follow-up methods. Psychosomatics 2001: 42: 55.
9. Gayowski T, Singh N, Keyes L et al. Late-onset renal failure after liver transplantation: role of posttransplant alcohol use. Transplantation 2000: 69: 383.
10. Lucey MR, Carr K, Beresford TP et al. Alcohol use after liver transplantation in alcoholics: a clinical cohort follow-up study. Hepatology 1997: 25: 1223.
11. Pageaux GP, Bismuth M, Perney P et al. Alcohol relapse after liver transplantation for alcoholic liver disease: does it matter? J Hepatol 2003: 38: 629.
12. Osorio RW, Ascher NL, Avery M, Bacchetti P, Roberts JP, Lake JR. Predicting recidivism after orthotopic liver transplantation for alcoholic liver disease. Hepatology 1994: 20: 105.
13. O'Grady JGM, Asderakis A, Bradley R et al. Multidisciplinary insights into optimizing adherence after solid organ transplantation. Transplantation 2010: 89: 627.
14. Garber MC, Nau DP, Erickson SR, Aikens JE, Lawrence JB. The concordance of self-report with other measures of medication adherence: a summary of the literature. Med Care 2004: 42: 649.
15. Walsh JC, Mandalia S, Gazzard BG. Responses to a 1month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome. AIDS 2002: 16: 269.
16. Haynes RB, Taylor DW, Sackett DL, Gibson ES, Baerholz CD, Mukherjee J. Can simple clinical measurements detect patient noncompliance? Hypertension 1980: 2: 757.
17. Schafer-Keller P, Steiger J, Bock A, Denhaerynck K, De Geest S. Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients. Am J Transplant 2008: 8: 616.
18. Denhaerynck K, Manhaeve D, Dobbels F, Garzoni D, Nolte C, De Geest S. Prevalence and consequences of nonadherence to hemodialysis regimens. Am J Crit Care 2007: 16: 222, quiz 236.
19. Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation 2004: 77: 769.
20. Chisholm MA, Lance CE, Williamson GM, Mulloy LL. Development and validation of the immunosuppressant therapy adherence instrument (ITAS). Patient Educ Couns 2005: 59: 13.
21. Russell CL, Kilburn E, Conn VS, Libbus MK, Ashbaugh C. Medication-taking beliefs of adult renal transplant recipients. Clin Nurse Spec 2003: 17: 200, quiz 209-230.
22. Medical Outcomes Study: Social Support Survey. Available at Accessed January 20, 2011.
23. Wallston KA. Multidimensional health locus of control (MHLC) scales. Available at Accessed January 20, 2011.
24. Frazier PA, Davis-Ali SH, Dahl KE. Correlates of noncompliance among renal transplant recipients. Clin Transplant 1994: 8: 550.
25. Raiz LR, Kilty KM, Henry ML, Ferguson RM. Medication compliance following renal transplantation. Transplantation 1999: 68: 51.
26. Greenstein S, Siegal B. Compliance and noncompliance in patients with a functioning renal transplant: a multicenter study. Transplantation 1998: 66: 1718.
27. Beresford TP, Schwartz J, Wilson D, Merion R, Lucey MR. The short-term psychological health of alcoholic and non-alcoholic liver transplant recipients. Alcohol Clin Exp Res 1992: 16: 996.
28. Shemesh E, Shneider BL, Savitzky JK et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 2004: 113: 825.
29. Drent G, Haagsma EB, Geest SD et al. Prevalence of prednisolone (non)compliance in adult liver transplant recipients. Transpl Int 2005: 18: 960.
30. Stilley CS, DiMartini AF, De Vera ME et al. Individual and environmental correlates and predictors of early adherence and outcomes after liver transplantation. Prog Transplant 2010: 20: 58.
31. Berlakovich GA, Langer F, Freundorfer E et al. General compliance after liver transplantation for alcoholic cirrhosis. Transpl Int 2000: 13: 129.
32. Lurie S, Shemesh E, Sheiner PA et al. Non-adherence in pediatric liver transplant recipients--an assessment of risk factors and natural history. Pediatr Transplant 2000: 4: 200.
33. Berquist RK, Berquist WE, Esquivel CO, Cox KL, Wayman KI, Litt IF. Adolescent non-adherence: prevalence and consequences in liver transplant recipients. Pediatr Transplant 2006: 10: 304.
34. Hansen R, Seifeldin R, Noe L. Medication adherence in chronic disease: issues in posttransplant immunosuppression. Transplant Proc 2007: 39: 1287.
35. Dew MA, Kormos RL, Roth LH, Murali S, DiMartini A, Griffith BP. Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation. J Heart Lung Transplant 1999: 18: 549.
36. Chisholm-Burns MA, Kwong WJ, Mulloy LL, Spivey CA. Nonmodifiable characteristics associated with nonadherence to immunosuppressant therapy in renal transplant recipients. Am J Health Syst Pharm 2008: 65: 1242.
37. Kasiske BL, Cohen D, Lucey MR, Neylan JF. Payment for immunosuppression after organ transplantation. American Society of Transplantation. JAMA 2000: 283: 2445.
38. Willoughby LM, Fukami S, Bunnapradist S et al. Health insurance considerations for adolescent transplant recipients as they transition to adulthood. Pediatr Transplant 2007: 11: 127.
39. Stilley CS, Lawrence K, Bender A, Olshansky E, Webber SA, Dew MA. Maturity and adherence in adolescent and young adult heart recipients. Pediatr Transplant 2006: 10: 323.
40. Shemesh E, Annunziato RA, Shneider BL et al. Improving adherence to medications in pediatric liver transplant recipients. Pediatr Transplant 2008: 12: 316.