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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3056-3062

Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors

(18) Fernandez, Maria Carmen a Escribano, Ana a Mateo, Ana I a Parthasarathy, Saravanan b Martin De La Nava, Eva M a Wang, Xiaodong c Cockerham, Sandra L b Beyer, Thomas P b Schmidt, Robert J b Cao, Guoqing c Zhang, Youyan b Jones, Timothy M b Borel, Anthony b Sweetana, Stephanie A b Cannady, Ellen A b Stephenson, Gregory b Frank, Scott b Mantlo, Nathan B b

a ELI LILLY AND COMPANY (Spain)

b ELI LILLY AND COMPANY (United States)

c Hengrui Pharmaceutical ^* (China)

Author keywords

1,5 Tetrahydronaphthyridines; CETP inhibitor; CVD; HDL c

Indexed keywords

1,5 TETRAHYDRONAPHTHYRIDINE DERIVATIVE; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; CORN OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; NAPHTHYRIDINE DERIVATIVE; OLEIC ACID; SOLUTOL HS 15; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CIS ISOMER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG SYNTHESIS; EXPERIMENTAL DOG; EXPERIMENTAL MONKEY; FEMALE; HETEROZYGOTE; IC 50; MALE; MOUSE; NONHUMAN; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

MUS;

EID: 84859848153 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.075 Document Type: Article

Times cited : (24)

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