Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3265-3268

  Nilsson, Magnus ^a   Kalayanov, Genadiy ^a   Winqvist, Anna ^a   Pinho, Pedro ^a   Sund, Christian ^a   Zhou, Xiao Xiong ^a   Wähling, Horst ^a   Belfrage, Anna Karin ^a   Pelcman, Michael ^a   Agback, Tatiana ^a   Benckestock, Kurt ^a   Wikström, Kristina ^a   Boothee, Mirva ^a   Lindqvist, Anneli ^a   Rydegrd, Christina ^a   Jonckers, Tim H M ^b   Vandyck, Koen ^b   Raboisson, Pierre ^b   Lin, Tse I ^b   Lachau Durand, Sophie ^b   De Kock, Herman ^b   Smith, David B ^c   Martin, Joseph A ^c   Klumpp, Klaus ^c   Simmen, Kenneth ^b   Vrang, Lotta ^a   Terelius, Ylva ^a   Samuelsson, Bertil ^a   Rosenquist, Åsa ^a   Johansson, Nils Gunnar ^a   more..

^a MEDIVIR AB   (Sweden)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c ROCHE BIOSCIENCE   (United States)

Author keywords

Antivirals; Hepatitis C virus; NS5B polymerase; Nucleoside; Phosphoramidate; Prodrug

Indexed keywords

4' AZIDO 2' DEOXY 2' METHYLCYTIDINE; 4' AZIDO 2' DEOXY 2' METHYLCYTIDINE DERIVATIVE; ANTIVIRUS AGENT; CYTIDINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; CYTIDINE; DRUG DERIVATIVE; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL LINE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN; LIPOPHILICITY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VIRUS REPLICATION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT;

HEPATITIS C VIRUS; RATTUS;

ANIMALS; ANTIVIRAL AGENTS; CYTIDINE; DRUG DISCOVERY; HEPACIVIRUS; PRODRUGS; RATS; RNA REPLICASE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84859840993     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.021     Document Type: Article

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