Practical synthesis of (2′ R)-2′-deoxy-2′-C-methyluridine by highly diastereoselective homogeneous hydrogenation

Journal of Organic Chemistry

Volumn 76, Issue 1, 2011, Pages 297-300

  Lemaire, Sébastien ^a   Houpis, Ioannis ^a   Wechselberger, Rainer ^a   Langens, Jaak ^a   Vermeulen, Wim A A ^a   Smets, Nico ^a   Nettekoven, Ulrike ^b   Wang, Youchu ^c   Xiao, Tingting ^c   Qu, Haisheng ^c   Liu, Renmao ^c   Jonckers, Tim H M ^d   Raboisson, Pierre ^d   Vandyck, Koen ^d   Nilsson, Karl M ^e   Farina, Vittorio ^a  

^a JOHNSON AND JOHNSON   (United States)

^b SOLVIAS AG   (Switzerland)

^c WUXI APPTEC   (China)

^d TIBOTEC BVBA   (Belgium)

^e MEDIVIR AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIASTEREOSELECTIVE; DIASTEREOSELECTIVE HYDROGENATION; HOMOGENEOUS CONDITIONS; LOW LOADING; RH CATALYSTS; TITLE COMPOUNDS;

PILOT PLANTS; RHODIUM; STEREOSELECTIVITY;

HYDROGENATION;

2' DEOXY 2' METHYLENEURIDINE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DIASTEREOISOMER; HYDROGENATION; STEREOCHEMISTRY; SYNTHESIS;

CATALYSIS; HYDROGENATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STEREOISOMERISM; URIDINE;

EID: 78650872293     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101822j     Document Type: Article

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24. A full description of the screening results can be found in the Supporting Information.