N-terminal acetylation and other functions of Nα- acetyltransferases

Biological Chemistry

Volumn 393, Issue 4, 2012, Pages 291-298

  Hollebeke, Jolien ^a,b   Van Damme, Petra ^a,b   Gevaert, Kris ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

N acetylation; N terminal acetylation of proteins; N acetyltransferases

Indexed keywords

ACYLTRANSFERASE; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; AMINO ACID; CASPASE 2; CASPASE 3; CASPASE 9; CHAPERONE; DNA METHYLTRANSFERASE 1; G PROTEIN COUPLED RECEPTOR KINASE; MYOSIN LIGHT CHAIN; PROTEIN BCL XL; SIGNAL RECOGNITION PARTICLE;

ACETYLATION; APOPTOSIS; ARABIDOPSIS; CELL CYCLE REGULATION; CELL MIGRATION; CELL ORGANELLE; CHLAMYDOMONAS REINHARDTII; CONFERENCE PAPER; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GOLGI COMPLEX; HALF LIFE TIME; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; QUALITY CONTROL; SIGNAL TRANSDUCTION; UBIQUITINATION;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS;

EID: 84859825973     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2011-0228     Document Type: Conference Paper

References (40)

1. Abe, A., Saeki, K., Yasunaga, T., and Wakabayashi, T. (2000). Acetylation at the N-terminus of actin strengthens weak interaction between actin and myosin. Biochem. Biophys. Res. Commun. 268, 14-19. (Pubitemid 30116602)
2. Arnesen, T., Gromyko, D., Horvli, D., Fluge, O., Lillehaug, O., and Varhaug, J.E. (2005a). Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms. Thyroid 15, 1131-1136. (Pubitemid 41720719)
3. Arnesen, T., Kong, X., Evjenth, R., Gromyko, D., Varhaug, J.E., Lin, Z., Sang, N., Caro, J., and Lillehaug, J.R. (2005b). Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha. FEBS Lett. 579, 6428-6432. (Pubitemid 41612163)
4. Behnia, R., Panic, B., Whyte, J.R., and Munro, S. (2004). Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat. Cell Biol. 6, 405-413. (Pubitemid 38607500)
5. Bienvenut, W.V., Espagne, C., Martinez, A., Majeran, W., Valot, B., Zivy, M., Vallon, O., Adam, Z., Meinnel T., and Giglione, C. (2011). Dynamics of post-translational modifications and protein stability in the stroma of Chlamydomonas reinhardtii chloroplasts. Proteomics 11, 1734-1750.
6. Bradshaw, R.A., Brickey, W.W., and Walker, K.W. (1998). N-terminal processing: the methionine aminopeptidase and Nα-acetyl transferase families. Trends Biochem. Sci. 23, 263-267. (Pubitemid 28343371)
7. Brown, J.L. (1979). A comparison of the turnover of alpha-Nacetylated and nonacetylated mouse L-cell proteins. J. Biol. Chem. 254, 1447-1449.
8. Coulton, A.T., East, D.A., Galinska-Rakoczy, A., Lehman, W., and Mulvihill, D.P. (2010). The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. J. Cell Sci. 123, 3235-3243.
9. Forte, G.M., Pool, M.R., and Stirling, C.J. (2011). N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum. PLoS Biol. 9, e1001073.
10. Goetze, S., Qeli, E., Mosimann, C., Staes, A., Gerrits, B., Roschitzki, B., Mohanty, S., Niederer, E.M., Laczko, E., Timmerman, E., et al. (2009). Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol. 7, e1000236.
11. Gromyko, D., Arnesen, T., Ryningen, A., Varhaug, J.E., and Lillehaug, J.R. (2010). Depletion of the human Nalpha-terminal acetyltransferase A induces p53-dependent apoptosis and p53- independent growth inhibition. Int. J. Cancer 127, 2777-2789.
12. Guo, L., Münzberg, H., Stuart, R.C., Nillni, E.A., and Bjørbæk, C. (2004). N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin. Proc. Natl. Acad. Sci. USA 101, 11797-11802. (Pubitemid 39095374)
13. Hershko, A., Heller, H., Eytan, E., Kaklij, G., and Rose, I.A. (1984). Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. Proc. Natl. Acad. Sci. USA 81, 7021-7025. (Pubitemid 15216689)
14. Hofmann, I. and Munro, S. (2006). An N-terminally acetylated Arflike GTPase is localised to lysosomes and affects their motility. J. Cell Sci. 119, 1494-1503. (Pubitemid 43732978)
15. Hole, K., Van Damme, P., Dalva, M., Aksnes, H., Glomnes, N., Varhaug, J.E., Lillehaug, J.R., Gevaert, K., and Arnesen, T. (2011). The human N-alpha-acetyltransferase 40 (hNaa40p/ hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS One 6, e24713.
16. Hua, K.-T., Tan, C.-T., Johansson, G., Lee, J.-M., Yang, P.-W., Lu, H.-Y., Chen, C.-K., Su, J.-L., Chen, P. B., Wu, Y.-L., et al. (2011). N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell 19, 218-231.
17. Hwang, C.-S., Shemorry, A., and Varshavsky, A. (2010). N-terminal acetylation of cellular proteins creates specific degradation signals. Science 327, 973-977.
18. Jeong, J.-W., Bae, M.-K., Ahn, M.-Y., Kim, S.-H., Sohn, T.-K., Bae, M.-H., Yoo, M.-A., Song, E.J., Lee, K.-J., and Kim, K.-W. (2002). Regulation and destabilization of HIF-1α by ARD1- mediated acetylation. Cell 111, 709-720. (Pubitemid 35441252)
19. Kamita, M., Kimura, Y., Ino, Y., Kamp, R.M., Polevoda, B., Sherman, F., and Hirano, H. (2011). N[α]-Acetylation of yeast ribosomal proteins and its effect on protein synthesis. J. Proteomics 74, 431-441.
20. Kuo, M.-L., den Besten, W., Bertwistle, D., Roussel, M.F., and Sherr, C.J. (2004). N-terminal polyubiquitination and degradation of the Arf tumor suppressor. Genes Dev. 18, 1862-1874. (Pubitemid 39025096)
21. Kuo, H.-P., Lee, D.-F., Chen, C.-T., Liu, M., Chou, C.-K., Lee, H.-J., Du, Y., Xie, X., Wei, Y., Xia, W., et al. (2010). ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci. Signal. 3, ra9.
22. Lee, F.J., Lin, L.W., and Smith, J.A. (1988). Purification and characterization of an N α-acetyltransferase from Saccharomyces cerevisiae. J. Biol. Chem. 263, 14948-14955.
23. Lee, C.-F., Ou, D.S.C., Lee, S.-B., Chang, L.-H., Lin, R.-K., Li, Y.-S., Upadhyay, A.K., Cheng, X., Wang, Y.-C., Hsu, H.-S., et al. (2010). hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing. J. Clin. Invest. 120, 2920-2930.
24. Lim, J.H., Park, J.W., and Chun, Y.S. (2006). Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell proliferation. Cancer Res. 66, 10677-10682.
25. Mullen, J.R., Kayne, P.S., Moerschell, R.P., Tsunasawa, S., Gribskov, M., Colavito-Shepanski, M., Grunstein, M., Sherman, F., and Sternglanz, R. (1989). Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J. 8, 2067-2075. (Pubitemid 19273535)
26. Persson, B., Flinta, C., von Heijne, G., and Jörnvall, H. (1985). Structures of N-terminally acetylated proteins. Eur. J. Biochem. 152, 523-527. (Pubitemid 16192357)
27. Pesaresi, P., Gardner, N.A., Masiero, S., Dietzmann, A., Eichacker, L., Wickner, R., Salamini, F., and Leister, D. (2003). Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis. Plant Cell 15, 1817-1832. (Pubitemid 37078337)
28. Polevoda, B. and Sherman, F. (2003). N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J. Mol. Biol. 325, 595-622. (Pubitemid 36268685)
29. Polevoda, B., Norbeck, J., Takakura, H., Blomberg, A., and Sherman, F. (1999). Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. EMBO J. 18, 6155-6168. (Pubitemid 29515690)
30. Polevoda, B., Arnesen, T., and Sherman, F. (2009). A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc. 3 (Suppl 6), S2.
31. Rope, A.F., Wang, K., Evjenth, R., Xing, J., Johnston, J.J., Swensen, J.J., Johnson, W.E., Moore, B., Huff, C.D., Bird, L.M., et al. (2011). Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am. J. Hum. Genet. 89, 28-43.
32. Shin, D.H., Chun, Y.S., Lee, K.H., Shin, H.W., and Park, J.W. (2009). Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase. PLoS One 4, e7451.
33. Starheim, K.K., Arnesen, T., Gromyko, D., Ryningen, A., Varhaug, J.E., and Lillehaug, J.R. (2008). Identification of the human N(alpha)- acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. Biochem. J. 415, 325-331.
34. Starheim, K.K., Gromyko, D., Evjenth, R., Ryningen, A., Varhaug, J.E., Lillehaug, J.R., and Arnesen, T. (2009). Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Mol. Cell. Biol. 29, 3569-3581.
35. Takubo, K., Tsuchiya, H., Kurimasa, A., Arnesen, T., Ryoke, K., and Shiota, G. (2009). Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. Anticancer Drugs 20, 668-675.
36. Van Damme, P., Arnesen, T., and Gevaert, K. (2011a). Protein alpha-N-acetylation studied by N-terminomics. FEBS J. 278, 3822-3834.
37. Van Damme, P., Evjenth, R., Foyn, H., Demeyer, K., De Bock, P.-J., Lillehaug, J.R., Vandekerckhove, J., Arnesen, T., and Gevaert, K. (2011b). Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of Nα-acetyltransferases and point to hNaa10p as the post-translational actin Nα-acetyltransferase. Mol. Cell. Proteomics 10, M110 004580.
38. Van Damme, P., Hole, K., Pimenta-Marques, A., Helsens, K., Vandekerckhove, J., Martinho, R.G., Gevaert, K., and Arnesen, T. (2011c). NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet. 7, e1002169.
39. Yi, C.H., Pan, H., Seebacher, J., Jang, I.-H., Hyberts, S.G., Heffron, G.J., Vander Heiden, M.G., Yang, R., Li, F., Locasale, J.W., et al. (2011). Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell 146, 607-620.
40. Zybailov, B., Rutschow, H., Friso, G., Rudella, A., Emanuelsson, O., Sun, Q., and van Wijk, K.J. (2008). Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. PLoS One 3, e1994.