Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: Validation with peripheral quantitative computed tomography

Journal of Bone and Mineral Metabolism

Volumn 30, Issue 2, 2012, Pages 222-231

  Briggs, Andrew M ^a,b   Perilli, Egon ^c,d   Parkinson, Ian H ^c,d   Kantor, Susan ^b   Wrigley, Tim V ^b   Fazzalari, Nicola L ^c,d   Wark, John D ^b  

^a CURTIN UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c HANSON INSTITUTE   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Bone mineral density; DXA; PQCT; Subregion; Vertebra

Indexed keywords

AGED; ARTICLE; BONE DENSITOMETRY; BONE DENSITY; BONE STRENGTH; CADAVER; CLINICAL ASSESSMENT TOOL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INSTRUMENT VALIDATION; MALE; OSTEOPOROSIS; PREDICTIVE VALIDITY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SENSITIVITY ANALYSIS; SPINE RADIOGRAPHY; VERTEBRA BODY; VERTEBRA FRACTURE; VOLUMETRY;

ABSORPTIOMETRY, PHOTON; BONE DENSITY; DENSITOMETRY; FEMALE; HUMANS; LINEAR MODELS; MALE; SPINE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84859810325     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-011-0307-3     Document Type: Article

References (53)

1. Genant HK, Engelke K, Prevrhal S (2008) Advanced CT bone imaging in osteoporosis. Rheumatology (Oxford) 47(Suppl 4):9-16
2. Marin F, Gonzalez-Macias J, Diez-Perez A, Palma S, Delgado- Rodriguez M (2006) Relationship between bone quantitative ultrasound and fractures: a meta-analysis. J Bone Miner Res 21:1126-1135 (Pubitemid 43962842)
3. Bauer JS, Link TM (2009) Advances in osteoporosis imaging. Eur J Radiol 71:440-449
4. Blake GM, Fogelman I (2009) The clinical role of dual energy X-ray absorptiometry. Eur J Radiol 71:406-414
5. Jergas M, Breitenseher M, Gluer CC, Yu W, Genant HK (1995) Estimates of volumetric bone density from projectional measurements improve the discriminatory capability of dual X-ray absorptiometry. J Bone Miner Res 10:1101-1110
6. Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254-1259 (Pubitemid 26147662)
7. Yu W, Gluer CC, Grampp S, Jergas M, Fuerst T, Wu CY, Lu Y, Fan B, Genant HK (1995) Spinal bone mineral assessment in postmenopausal women: a comparison between dual X-ray absorptiometry and quantitative computed tomography. Osteoporos Int 5:433-439
8. Johnell O, Kanis JA, Oden A, Johansson H, De Laet C, Delmas P, Eisman JA, Fujiwara S, Kroger H, Mellstrom D, Meunier PJ, Melton LJ, O'Neill T, Pols H, Reeve J, Silman A, Tenenhouse A (2005) Predictive value of BMD for hip and other fractures. J Bone Miner Res 20:1185-1194 (Pubitemid 40863806)
9. Briggs AM, Greig AM, Wark JD (2007) The vertebral fracture cascade in osteoporosis. A review of aetiopathogenesis. Osteoporos Int 18:575-584 (Pubitemid 46525549)
10. Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX(™) and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385-397
11. Rabier B, Heraud A, Grand-Lenoir C, Winzenrieth R, Hans D (2010) A multicentre, retrospective case-control study assessing the role of trabecular bone score (TBS) in menopausal Caucasian women with low areal bone mineral density (BMDa): analysis of the odds of vertebral fracture. Bone 46:176-181
12. Chen P, Miller PD, Binkley NC, Kendler DL, Wong M, Krohn K (2008) Use of lowest single lumbar spine vertebra bone mineral density T-score and other T-score approaches for diagnosing osteoporosis and relationships with vertebral fracture status. J Clin Densitom 11:525-531
13. Antonacci MD, Hanson DS, Leblanc A, Heggeness MH (1997) Regional variation in vertebral bone density and trabecular architecture are influenced by osteoarthritic change and osteoporosis. Spine 22:2393-2401
14. Banse X, Devogelaer JP, Munting E, Delloye C, Cornu O, Grynpas M (2001) Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body. Bone 28:563-571 (Pubitemid 32410008)
15. Briggs AM, Perilli E, Parkinson IH, Wrigley TV, Fazzalari NL, Kantor S, Wark JD (2010) Novel assessment of subregional bone mineral density using DXA and pQCT, and subregional micro-architecture using micro-CT in whole human vertebrae: applications, methods, and correspondence between technologies. J Clin Densitom 13:161-174
16. Briggs AM, Wark JD, Greig AM, Fazzalari NL, Kantor S, Bennell KL (2009) Subregional bone mineral density measurement in the lumbar spine using DXA: potential for the application to osteoporosis and vertebral fractures. In: Mattingly BE, Pillare AC (eds) Osteoporosis: etiology, diagnosis and treatment. Nova Publishers, New York, pp 1-50
17. Briggs AM, Wark JD, Kantor S, Fazzalari NL, Greig AM, Bennell KL (2006) Bone mineral density distribution in thoracic and lumbar vertebrae: an ex vivo study using dual energy X-ray absorptiometry. Bone 38:286-288 (Pubitemid 43165795)
18. Cvijanovic O, Bobinac D, Zoricic S, Ostojic Z, Maric I, Crncevic- Orlic Z, Kristofic I, Ostojic L (2004) Age- and region-dependent changes in human lumbar vertebral bone. A histomorphometric study. Spine 24:2370-2375 (Pubitemid 40353290)
19. Keller TS, Moeljanto E, Main JA, Spengler DM (1992) Distribution and orientation of bone in the human lumbar vertebral centrum. J Spinal Disord 5:60-74
20. Krueger D, Todd H, Haffa A, Bruner J, Yandow D, Binkley N (1999) Central region-of-interest analysis of lumbar spine densitometry demonstrates lower bone mass in older rhesus monkeys. Bone 24:29-33 (Pubitemid 28546703)
21. Lu WW, Zheng YG, Holmes A, Zhu QG, Luk KDK, Zhong SZ, Leong JCY (2000) Bone mineral density variations along the lumbosacral spine. Clin Orthop Relat Res 378:255-263
22. Nepper-Rasmussen HJ, Mosekilde L (1989) Local differences in mineral content in vertebral trabecular bone measured by dual-energy computed tomography. Acta Radiol 4:369-371
23. Oda K, Shibayama V, Abe M, Onomura T (1998) Morphogenesis of vertebral deformities in involutional osteoporosis - age-related, three-dimensional trabecular structure. Spine 23:1050-1055
24. Pollintine P, Dolan P, Tobias JH, Adams MA (2004) Intervertebral disc degeneration can lead to "stress-shielding" of the anterior vertebral body - a cause of osteoporotic vertebral fracture? Spine 29:774-782 (Pubitemid 38437527)
25. Sandor TA, Felsenberg D, Kalender WA, Brown E (1991) Global and regional variations in the spinal trabecular bone: single and dual energy examinations. J Clin Endocrinol Metab 72:1157-1168 (Pubitemid 21921822)
26. Simpson EK, Parkinson IH, Manthey B, Fazzalari NL (2001) Intervertebral disc disorganisation is related to trabecular bone architecture in the lumbar spine. J Bone Miner Res 16:681-687 (Pubitemid 32230596)
27. Engelke K, Fuerst T, Dasic G, Davies RY, Genant HK (2010) Regional distribution of spine and hip QCT BMD responses after one year of once-monthly ibandronate in postmenopausal osteoporosis. Bone 46:1626-1632
28. McCubbery DA, Cody DD, Peterson EL, Kuhn JL, Flynn MJ, Goldstein SA (1995) Static and fatigue failure properties of thoracic and lumbar vertebral bodies and their relation to regional density. J Biomech 28:891-899
29. Kim DG, Hunt CA, Zauel R, Fyhrie DP, Yeni YN (2007) The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies. Ann Biomed Eng 35:1907-1913 (Pubitemid 47631061)
30. Briggs AM, Wark JD, Kantor S, Teh R, Greig AM, Fazzalari NL, Bennell KL (2005) In vivo intra-rater and inter-rater precision of measuring apparent bone mineral density in vertebral subregions using supine lateral dual-energy x-ray absorptiometry (DXA). J Clin Densitom 8:314-319 (Pubitemid 41112848)
31. Edmondston SJ, Singer KP, Day RE, Breidahl PD, Price RI (1994) Formalin fixation effects on vertebral bone density and failure mechanics. An in vitro study of human and sheep vertebrae. Clin Biomech 9:175-179 (Pubitemid 24127339)
32. Bürklein D, Lochmuller EM, Kuhn V, Grimm J, Barkmann R, Muller R, Eckstein F (2001) Correlation of thoracic and lumbar vertebral failure loads with in situ vs. ex situ dual energy X-ray absorptiometry. J Biomech 34:579-587 (Pubitemid 32328245)
33. Edmondston SJ, Singer KP, Price RI, Breidahl PD (1993) Accuracy of lateral dual-energy X-ray absorptiometry for the determination of bone mineral content in the thoracic and lumbar spine: an in vitro study. Br J Radiol 66:309-313 (Pubitemid 23120024)
34. Kaymakci B, Wark JD (1994) Precise accurate mineral measurements of excised sheep bones using X-ray densitometry. Bone Min 25:231-246 (Pubitemid 24183712)
35. Singer K, Edmondston S, Day R, Breidahl P, Price R (1995) Prediction of thoracic and lumbar vertebral body compressive strength: correlations with bone mineral density and vertebral region. Bone 17:167-174
36. Sran MM, Khan KM, Keiver K, Chew JB, McKay HA, Oxland TR (2005) Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume. Eur Spine J 14:971-976 (Pubitemid 41798048)
37. Jones G, White C, Nguyen T, Sambrook PN, Kelly PJ, Eisman JA (1996) Prevalent vertebral deformities: relationship to bone mineral density and spinal osteophytosis in elderly men and women. Osteoporos Int 6:233-239 (Pubitemid 26171277)
38. Briggs AM (2006) Pathomechanics of spinal osteoporosis: sub-regional bone mineral density and physiologic loading [Ph.D. thesis]. The University of Melbourne, Melbourne
39. Silva MJ, Keaveny TM, Hayes WC (1997) Load sharing between the shell and centrum in the lumbar vertebral body. Spine 22:140-150 (Pubitemid 27081629)
40. Homminga J, Weinans H, Gowin W, Felsenberg D, Huiskes R (2001) Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution. Spine 24:1555-1561
41. Eckstein F, Fischbeck M, Kuhn V, Link TM, Priemel M, Lochmuller EM (2004) Determinants and heterogeneity of mechanical competence throughout the thoracolumbar spine of elderly women and men. Bone 35:364-374 (Pubitemid 38953181)
42. Pollintine P, Przybyla AS, Dolan P, Adams MA (2004) Neural arch load-bearing in old and degenerated spines. J Biomech 37:197-204 (Pubitemid 38050050)
43. Grant JP, Oxland TR, Dvorak MF (2001) Mapping the structural properties of the lumbosacral vertebral endplates. Spine 26:889-896 (Pubitemid 32373975)
44. Meng XL, Roesenthal R, Rubin DB (1992) Comparing correlated correlation coefficients. Psychol Bull 111:172-175
45. Briggs AM, Kantor S, Greig AM, Fazzalari N, Wark JD (2006) Subregional BMD is a better predictor of vertebral morphology than standard DXA-derived BMD measures. Australian and New Zealand Bone and Mineral Society and International Osteoporosis Federation Scientific Meeting; 2006; Cairns, Australia
46. Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L (1999) Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing. Bone 25:713-724 (Pubitemid 29525438)
47. Lochmuller EM, Burklein D, Kuhn V, Glaser C, Muller R, Gluer CC, Eckstein F (2002) Mechanical strength of the thoracolumbar spine in the elderly: prediction from in situ dual-energy X-ray absorptiometry, quantitative computed tomography (QCT), upper and lower limb peripheral QCT, and quantitative ultrasound. Bone 31:77-84 (Pubitemid 34754429)
48. Prevrhal S, Shepherd JA, Faulkner KG, Gaither KW, Black DM, Lang TE (2008) Comparison of DXA hip structural analysis with volumetric QCT. J Clin Densitom 11:232-236
49. Sosa M, Hernandez D, Estevez S, Rodriguez M, Liminana JM, Saavedra P, Lainez P, Diaz P, Betancor P (1998) The range of bone mineral density in healthy Canarian women by dual X-ray absorptiometry radiography and quantitative computer tomography. J Clin Densitom 1:385-393 (Pubitemid 128348661)
50. Grampp S, Genant HK, Mathur A, Lang P, Jergas M, Takada M, Gluer CC, Lu Y, Chavez M (1997) Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification. J Bone Miner Res 12:697-711 (Pubitemid 27200321)
51. Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde LI (1998) Vertebral bone density evaluated by DXA and QCT in vitro. Bone 23:283-290
52. Cheng XG, Nicholson PHF, Boonen S, Lowet G, Brys P, Aerssens J, VanderPerre G, Dequeker J (1997) Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound. J Bone Miner Res 12:1721-1728 (Pubitemid 27422374)
53. Kopperdahl DL, Morgan EF, Keaveny TM (2002) Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone. J Orthop Res 20:801-805 (Pubitemid 34823001)