Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 8, 2012, Pages

  Gallego Martin, Teresa ^a   Fernandez Martinez, Silvia ^a   Rigual, Ricardo ^a   Obeso, Ana ^a   Gonzalez, Constancio ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Catecholamine; Glucoreceptor; Hypoglycemia; Intracellular calcium

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM; CATECHOLAMINE; GLUCORECEPTOR; GLUCOSE; NIFEDIPINE; SODIUM ION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAROTID BODY CHEMORECEPTOR; CELL ACTIVITY; CONTROLLED STUDY; FEMALE; FLUORESCENCE; GLUCOSE HOMEOSTASIS; GLYCOLYSIS; HYPOGLYCEMIA; HYPOXIA; MALE; MICROENVIRONMENT; NEUROSECRETION; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; RAT; SODIUM CELL LEVEL;

ANIMALS; CALCIUM; CAROTID BODY; CATECHOLAMINES; CELL CULTURE TECHNIQUES; CELL HYPOXIA; CHEMORECEPTOR CELLS; FEMALE; GLUCOSE; GLYCOLYSIS; HYPOGLYCEMIA; IMMUNOHISTOCHEMISTRY; MALE; NIFEDIPINE; POTASSIUM; RATS; RATS, WISTAR; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 84859795582     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00196.2011     Document Type: Article

References (59)

1. Almaraz L, Obeso A, Gonzalez C. Metabolic dissociation of carotid body chemoreceptors responses to different types of stimulation: preliminary findings. In: The Peripheral Arterial Chemoreceptors, edited by Pallot DJ. New York: Oxford University Press, 1984. p. 141-151.
2. Alvarez-Buylla R, Alvarez-Buylla ER. Carotid sinus receptors participate in glucose homeostasis. Respir Physiol 723: 347-359, 1988.
3. Bertram R, Satin LS, Pedersen MG, Luciani DS, Sherman A. Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Biophys J 92: 1544-1555, 2007.
4. Bin-Jaliah I, Maskell PD, Kumar P. Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat. J Physiol 556: 225-266, 2004.
5. Bin-Jaliah I, Maskell PD, Kumar P. Carbon dioxide sensitivity during hypoglycaemia-induced, elevated metabolism in the anaesthetized rat. J Physiol 563: 883-893, 2005.
6. Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev 79: 763-854, 1999.
7. Buckler KJ, Vaughan-Jones RD. Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J Physiol 476: 423-428, 1994.
8. Caceres AI, Obeso A, Gonzalez C, Rocher A. Molecular identification and functional role of voltage-gated sodium channels in rat carotid body chemoreceptor cells. Regulation of expression by chronic hypoxia in vivo. J Neurochem 102: 231-245, 2007.
9. Caceres AI, Gonzalez-Obeso E, Gonzalez C, Rocher A. RT-PCR and pharmacological analysis of L-and T-type calcium channels in rat carotid body. Adv Exp Med Biol 648: 105-112, 2009.
10. Cho S, Wood A, Bowlby MR. Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics. Curr Neuropharmacol 5: 19-33, 2007.
11. Conde SV, Obeso A, Gonzalez C. Low glucose effects on rat carotid body chemoreceptor cells' secretory responses and action potential frequency in the carotid sinus nerve. J Physiol 585: 721-730, 2007.
12. Dai G, Tsukurov O, Orkin RW, Abbott WM, Kamm RD, Gertler JP. An in vitro cell culture system to study the influence of external pneumatic compression on endothelial function. J Vasc Surg 32: 977-987, 2000.
13. Drexler B, Hentschke H, Antkowiak B, Grasshoff C. Organotypic cultures as tools for testing neuroactive drugs-link between in-vitro and in-vivo experiments. Curr Med Chem 17: 4538-4550, 2010.
14. Eisner DA, Lederer WJ, Vaughan Jones RD. The quantitative relationship between twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres. J Physiol 355: 251-266, 1984.
15. Fidone SJ, Gonzalez C. Catecholamine synthesis in rabbit carotid body in vitro. J Physiol 333: 69-79, 1982.
16. Fidone S, Gonzalez C. Initiation and control of chemoreceptor activity in the carotid body. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 1, chapt. 9, p. 247-312.
17. Fitzgerald RS, Shirahata M. Systemic responses elicited by stimulating the carotid body: primary and secondary mechanisms. In: Carotid Body Chemoreceptors, edited by Gonzalez C. New York: Springer-Verlag, 1997, p. 171-202.
18. Gähwiler BH, Capogna M, Debanne D, McKinney RA, Thompson SM. Organotypic slice cultures: a technique has come of age. Trends Neurosci 20: 471-477, 1997.
19. Gallego R, Belmonte C. The effects of blood osmolality changes on cat carotid body chemoreceptors in vivo. Pflügers Arch 380: 53-58, 1979.
20. García AG, García-De-Diego AM, Gandía L, Borges R, García-Sancho J. Calcium signaling and exocytosis in adrenal chromaffin cells. Physiol Rev 86: 1093-1131, 2006.
21. Garcia-Fernandez M, Ortega-Saenz P, Castellano A, Lopez-Barneo J. Mechanisms of low-glucose sensitivity in carotid body glomus cells. Diabetes 56: 2893-2900, 2007.
22. Gauda EB. Gene expression in peripheral arterial chemoreceptors. Microsc Res Tech 59: 153-167, 2002.
23. Gauda EB, Cooper R, Johnson SM, McLemore GL, Marshall C. Autonomic microganglion cells: a source of acetylcholine in the rat carotid body. J Appl Physiol 96: 384-391, 2004.
24. Gomez-Nino A, Obeso A, Baranda JA, Santo-Domingo J, Lopez-Lopez JR, Gonzalez C. MaxiK potassium channels in the function of chemoreceptor cells of the rat carotid body. Am J Physiol Cell Physiol 297: C715-C722, 2009.
25. Gonzalez C, Almaraz L, Obeso A, Rigual R. Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci 15: 146-153, 1992.
26. Gonzalez C, Almaraz L, Obeso A, Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74: 829-898, 1994.
27. Heinert G, Paterson DJ, Bisgard GE, Xia N, Painter R, Nye PC. The excitation of carotid body chemoreceptors of the cat by potassium and noradrenaline. Adv Exp Med Biol 393: 323-330, 1995.
28. 2+ levels and secretion of catecholamines in cultured adrenal chromaffin cells. Neurochem Int 28: 325-334, 1996.
29. Honda Y. Role of carotid chemoreceptors in control of breathing at rest and in exercise: studies on human subjects with bilateral carotid body resection. Jpn J Physiol 35: 535-544, 1985.
30. Ishihara H, Wollheim CB. What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion? IUBMB Life 49: 391-395, 2000.
31. Koyama Y, Coker RH, Denny JC, Lacy DB, Jabbour K, Williams PE, Wasserman DH. Role of carotid bodies in control of the neuroendocrine response to exercise. Am J Physiol Endocrinol Metab 281: E742-E748, 2001.
32. Koyama Y, Coker RH, Stone EE, Lacy DB, Jabbour K, Williams PE, Wasserman DH. Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes 49: 1434-1442, 2000.
33. Kumar P. How sweet it is: sensing low glucose in the carotid body. J Physiol 578: 627, 2007.
34. + current modulated by PO2 in type I chemoreceptor cells. Science 241: 580-582, 1988.
35. 2+ homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures. Neuroscience 128: 729-740, 2004.
36. McTaggart JS, Clark RH, Ashcroft FM. The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet. J Physiol 588: 3201-3209, 2010.
37. Mir AK, Al-Neamy K, Pallot DJ, Nahorski SR. Catecholamines in the carotid body of several mammalian species: effects of surgical and chemical sympathectomy. Brain Res 252: 335-342, 1982.
38. Neher E, Sakaba T. Multiple roles of calcium ions in the regulation of neurotransmitter release. Neuron 59: 861-872, 2008.
39. Obeso A, Almaraz L, Gonzalez C. Effects of 2-deoxy-D-glucose on in vitro cat carotid body. Brain Res 371: 25-36, 1986.
40. Pardal R, Lopez-Barneo L. Low glucose-sensing cells in the carotid body. Nat Neurosci 5: 197-198, 2002.
41. Paterson DJ, Nye PC. The effect of beta adrenergic blockade on the carotid body response to hyperkalaemia in the cat. Respir Physiol 74: 229-237, 1988.
42. Peers C. Interactions of chemostimuli at the single cell level: studies in a model system. Exp Physiol 89: 60-65, 2004.
43. Randall KJ, Turton J, Foster JR. Explant culture of gastrointestinal tissue: a review of methods and applications. Cell Biol Toxicol 27: 267-284, 2011.
44. Reyes EP, Fernandez R, Larrain C, Zapata P. Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro. Respir Physiol Neurobiol 156: 17-22, 2007.
45. Reyes EP, Fernandez R, Larrain C, Zapata P. Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic block. Respir Physiol Neurobiol 156: 23-32, 2007.
46. Rocher A, Obeso A, Gonzalez C, Herreros B. Ionic mechanisms for the transduction of acidic stimuli in rabbit carotid body glomus cells. J Physiol 433: 533-548, 1991.
47. Rocher A, Geijo-Barrientos E, Caceres AI, Rigual R, Gonzalez C, Almaraz L. Role of voltage-dependent calcium channels in stimulussecretion coupling in rabbit carotid body chemoreceptor cells. J Physiol 562: 407-420, 2005.
48. Sener A, Kawazu S, Hutton JC, Boschero AC, Devis G, Somers G, Herchuelz A, Malaisse WJ. The stimulus-secretion coupling of glucoseinduced insulin release. Effect of exogenous pyruvate on islet function. Biochem J 176: 217-232, 1978.
49. Teppema LJ, Dahan A. The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis. Physiol Rev 90: 675-754, 2010.
50. Vicario I, Rigual R, Obeso A, Gonzalez C. Characterization of the synthesis and release of catecholamine in the rat carotid body in vitro. Am J Physiol Cell Physiol 278: C490-C499, 2000.
51. Ward DS, Voter WA, Karan S. The effects of hypo- and hyperglycaemia on the hypoxic ventilatory response in humans. J Physiol 582: 859-869, 2007.
52. Ward DS, Voter WA, Karan S. The role of the carotid bodies in the counterregulatory response to hypoglycemia. Adv Exp Med Biol 648: 273-280, 2009.
53. Watts AG, Donovan CM. Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation. Front Neuroendocrinol 31: 32-43, 2010.
54. Wehrwein EA, Basu R, Basu A, Curry TB, Rizza RA, Joyner MJ. Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies? J Physiol 588: 4593-4601, 2010.
55. Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton 60: 24-34, 2005.
56. Yoshino H, Morita I, Murota SI, Ishikawa I. Mechanical stress induces production of angiogenic regulators in cultured human gingival and periodontal ligament fibroblasts. J Periodontal Res 38: 405-410, 2003.
57. Zapata P. Chemosensory activity in the carotid nerve: effects of pharmacological agents. In: The Carotid Body Chemoreceptors, edited by Gonzalez C. New York: Springer-Verlag, 1997, p. 119-146.
58. Zhang M, Zhong H, Vollmer C, Nurse CA. Co-release of ATP and ACh mediates hypoxic signaling at rat carotid body chemoreceptors. J Physiol 525: 143-158, 2000.
59. Zhang M, Buttigieg J, Nurse C. Neurotransmitter mechanisms mediating low-glucose signalling in co-cultures and fresh tissue slices of rat carotid body. J Physiol 578: 735-750, 2007.