Vascular endothelial cadherin modulates renal interstitial fibrosis

Nephron - Experimental Nephrology

Volumn 120, Issue 1, 2012, Pages

  Yamaguchi, Ikuyo ^a,b   Tchao, Bie Nga ^b   Burger, Megan L ^b   Yamada, Muneharu ^b   Hyodo, Toshitake ^b   Giampietro, Costanza ^c   Eddy, Allison A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

Renal fibrosis; Renal microcirculation; Unilateral ureteral obstruction; Vascular endothelial cadherin

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; MESSENGER RNA; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY DENSITY; CELL EXPANSION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE EXPRESSION; KIDNEY FIBROSIS; MICROCIRCULATION; MOUSE; MYOFIBROBLAST; NONHUMAN; PERICYTE; PRIORITY JOURNAL; UPREGULATION; URETER OBSTRUCTION;

ANIMALS; ANTIGENS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BLOTTING, WESTERN; CADHERINS; CAPILLARY PERMEABILITY; COLLAGEN TYPE I; COLLAGEN TYPE III; DISEASE MODELS, ANIMAL; FIBRONECTINS; FIBROSIS; GENE EXPRESSION; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; KIDNEY; MACROPHAGES; MICE; MICE, KNOCKOUT; MYOFIBROBLASTS; PROTEOGLYCANS; RENAL CIRCULATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; URETERAL OBSTRUCTION;

EID: 84859791006     PISSN: None     EISSN: 16602129     Source Type: Journal    
DOI: 10.1159/000332026     Document Type: Article

References (45)

1. Collins AJ, Foley RN, Herzog C, Chavers BM, Gilbertson D, Ishani A, Kasiske BL, Liu J, Mau LW, McBean M, Murray A, St Peter W, Guo H, Li Q, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers PW, Agodoa L: Excerpts from the US Renal Data System 2009 Annual Data Report. Am J Kidney Dis 2010; 55:S1-S420, A426-A427.
2. Hallan SI, Coresh J, Astor BC, Asberg A, Powe N R, Romundsta d S, Hallan H A, Lydersen S, Holmen J: International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Ne-phrol 2006; 17:2275-2284. (Pubitemid 44141918)
3. Wasse H, McClellan W: Risk for progression to ESRD: further evidence from population-based studies. J Am Soc Nephrol 2006; 17: 2092-2093. (Pubitemid 44141894)
4. Eddy AA: Molecular basis of renal fibrosis. Pediatr Nephrol 2000; 15:290-301.
5. Chevalier RL, Forbes MS, Thornhill BA: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 2009; 75: 1145-1152.
6. Boor P, Ostendorf T, Floege J: Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 2010; 6:643-656.
7. Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ: Impaired angiogenesis in the remnant kidney model. II. Vascular en-dothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001; 12:1448-1457. (Pubitemid 32666327)
8. Kang DH, Joly AH, Oh SW, Hugo C, Ker-jaschki D, Gordon KL, Mazzali M, Jefferson JA, Hughes J, Madsen KM, Schreiner GF, Johnson RJ: Impaired angiogenesis in the remnant kidney model. I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 2001; 12:1434-1447. (Pubitemid 32666326)
9. Zhang B, Liang X, Shi W, Ye Z, He C, Hu X, Liu S: Role of impaired peritubular capillary and hypoxia in progressive interstitial fibro-sis after 56 subtotal nephrectomy of rats. Ne-phrology (Carlton) 2005; 10:351-357. (Pubitemid 41725510)
10. Ohashi R, Shimizu A, Masuda Y, Kitamura H, Ishizaki M, Sugisaki Y, Yamanaka N: Peritubular capillary regression during the progression of experimental obstructive ne-phropathy. J Am Soc Nephrol 2002; 13: 1795-1805. (Pubitemid 34700604)
11. Rouschop KM, Claessen N, Pals ST, Weening JJ, Florquin S: CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis. J Am Soc Nephrol 2006; 17:746-753.
12. Ishii Y, Sawada T, Kubota K, Fuchinoue S, Teraoka S, Shimizu A: Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathy. Kidney Int 2005; 67:321-332. (Pubitemid 40019255)
13. Choi YJ, Chakraborty S, Nguyen V, Nguyen C, Kim BK, Shim SI, Suki WN, Truong LD: Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endo-thelial growth factor. Hum Pathol 2000; 31: 1491-1497. (Pubitemid 32049007)
14. Seron D, Alexopoulos E, Raftery MJ, Hartley B, Cameron JS: Number of interstitial capillary cross-sections assessed by monoclonal antibodies: relation to interstitial damage. Nephrol Dial Transplant 1990; 5:889-893.
15. Manotham K, Tanaka T, Matsumoto M, Ohse T, Miyata T, Inagi R, Kurokawa K, Fujita T, Nangaku M: Evidence of tubular hyp oxia in the early phase in the remnant kidney model. J Am Soc Nephrol 2004; 15: 1277-1288. (Pubitemid 38526009)
16. Matsumoto M, Tanaka T, Yamamoto T, Noiri E, Miyata T, Inagi R, Fujita T, Nangaku M: Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis. J Am Soc Nephrol 2004; 15: 1574-1581. (Pubitemid 38679682)
17. Vestweber D, Winderlich M, Cagna G, Not-tebau m A F: C el l ad he s ion dy n a m ics at endo-thelial junctions: VE-cadherin as a major player. Trends Cell Biol 2009; 19: 8-15.
18. Lin SL, Kisseleva T, Brenner DA, Duffield JS: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627.
19. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre J V, Valerius MT, McMahon AP, Duffield JS: Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176:85-97.
20. Zeisberg EM, Potenta SE, Sugimoto H, Zeis-berg M, Kalluri R: Fibroblasts in kidney fi-brosis emerge via endothelial-to-mesenchy-mal transition. J Am Soc Nephrol 2008; 19: 2282-2287.
21. Dejana E: Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol 2004; 5: 261-270. (Pubitemid 38480607)
22. Dejana E, Bazzoni G, Lampugnani MG: Vascular endothelial (VE)-cadherin: only an intercellular glue? Exp Cell Res 1999; 252:13-19. (Pubitemid 29485122)
23. Dejana E, Tournier-Lasserve E, Weinstein BM: The control of vascular integrity by en-dothelial cell junctions: molecular basis and pathological implications. Dev Cell 2009; 16: 209-221.
24. Gavard J: Breaking the VE-cadherin bonds. FEBS Let t 2009; 583: 1-6.
25. Wallez Y, Vilgrain I, Huber P: Angiogenesis: the VE-cadherin switch. Trends Cardiovasc Med 2006; 16:55-59. (Pubitemid 43214527)
26. Gu l i no D, D e l ach a na l E, C oncord E, Genou x Y, Morand B, Valiron MO, Sulpice E, Scaife R, Alema ny M, Vernet T: Alteration of endo-thelial cell monolayer integrity triggers re-synthesis of vascular endothelium cadherin. J Biol Chem 1998; 273: 29786-29793. (Pubitemid 28509991)
27. Matsuo S, Lopez-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA: Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpress-ing mice. Kidney Int 20 05; 67: 2221-2238. (Pubitemid 41623383)
28. Yamaguchi I, Lopez-Guisa JM, Cai X, Collins SJ, Okamura DM, Eddy AA: Endogenous urokinase lacks antifibrotic activity during progressive renal injury. Am J Physi-ol Renal Physiol 2007; 293:F12-F19. (Pubitemid 47344995)
29. Zhang G, Kim H, Cai X, Lopez-Guisa JM, Alpers CE, Liu Y, Carmeliet P, Eddy AA: Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy. J Am Soc Nephrol 2003; 14:1254-1271. (Pubitemid 36514666)
30. Zhang G, Kim H, Cai X, Lopez-Guisa JM, Carmeliet P, Eddy AA: Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol 2003; 14:1234-1253. (Pubitemid 36514665)
31. Gerber HP, Hillan KJ, Ryan AM, Kowalski J, Keller GA, Rangell L, Wright BD, Radtke F, Aguet M, Ferrara N: VEGF is required for growth and survival in neonatal mice. Development 1999; 126:1149-1159. (Pubitemid 29182112)
32. Kang DH, Anderson S, Kim YG, Mazzalli M, Suga S, Jefferson JA, Gordon KL, Oyama TT, Hughes J, Hugo C, Kerjaschki D, Schreiner GF, Johnson RJ: Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis 2001; 37: 601-611. (Pubitemid 32195301)
33. Sutton TA, Mang HE, Campos SB, Sandoval RM, Yoder MC, Molitoris BA: Injury of the renal microvascular endothelium alters barrier function after ischemia. Am J Physiol Renal Physiol 2003; 285:F191-F198. (Pubitemid 36871191)
34. Schumacher J, Puchakayala MR, Binkowski K, Eichler W, Dendorfer A, Klotz KF: Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats. Br J Anaesth 2006; 96:437-443.
35. Rogers DF, Boschetto P, Barnes PJ: Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo. J Pharmacol Methods 1989; 21:309-315. (Pubitemid 19188105)
36. Ricardo SD, van Goor H, Eddy AA: Macro-phage diversity in renal injury and repair. J Clin Invest 2008; 118: 3522-3530.
37. Horbelt M, Lee SY, Mang HE, Knipe NL, Sado Y, Kribben A, Sutton TA: Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol 2007; 293:F688-F695. (Pubitemid 47403338)
38. Roussoulieres A, McGregor B, Chalabreysse L, Cerutti C, Garnier JL, Boissonnat P, Bas-tien O, Scoazec JY, Thivolet-Bejui F, Sebbag L, J LM: Expression of VE-cadherin in peri-tubular endothelial cells during acute rejection after human renal transplantation. J Biomed Biotechnol 2007; 2007: 41705.
39. Lelievre E, Mattot V, Huber P, Vandenbunder B, Soncin F: ETS1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin. Onco-gene 2000; 19: 2438-2446. (Pubitemid 30323477)
40. Birdsey GM, Dryden NH, Amsellem V, Geb-hardt F, Sahnan K, Haskard DO, Dejana E, Mason JC, Randi AM: Transcription factor ERG regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood 2008; 111: 3498-3506.
41. Deleuze V, Chalhoub E, El-Hajj R, Dohet C, Le Clech M, Couraud PO, Huber P, Mathieu D: TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells. Mol Cell Biol 2007; 27: 2687-2697. (Pubitemid 46581358)
42. Lopez D, Niu G, Huber P, Carter WB: Tumor-induced upregulation of twist, snail, and slug represses the activity of the human VE-cadherin promoter. Arch Biochem Bio-phys 2009; 482:77-82.
43. Wernert N, Raes MB, Lassalle P, Dehouck MP, Gosselin B, Vandenbunder B, Stehelin D: C-ETS1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans. Am J Pathol 1992; 140: 119-127.
44. Diaz-Flores L, Gutierrez R, Madrid JF, Varela H, Valladares F, Acosta E, Martin-Vasallo P, Diaz-Flores L Jr: Pericytes. Morpho-function, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 20 09; 24: 909-969.
45. von Tell D, Armulik A, Betsholtz C: Pericytes and vascular stability. Exp Cell Res 2006; 312: 623-629. (Pubitemid 43290338)