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Volumn 129, Issue SUPPL. 2, 2012, Pages

Novel molecules for the correction of factor Xa generation and phenotype in hemophilia

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; BAY 86 6150; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A; NEUTRALIZING ANTIBODY; RECOMBINANT BLOOD CLOTTING FACTOR 7A; UNCLASSIFIED DRUG;

EID: 84859790047     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2012.02.033     Document Type: Article
Times cited : (2)

References (38)
  • 1
    • 0026337077 scopus 로고
    • The coagulation cascade: Initiation, maintenance, and regulation
    • Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: Initiation, maintenance, and regulation. Biochemistry 1991;30:10363-70.
    • (1991) Biochemistry , vol.30 , pp. 10363-10370
    • Davie, E.W.1    Fujikawa, K.2    Kisiel, W.3
  • 3
    • 0025819780 scopus 로고
    • Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma
    • Nordfang O, Valentin S, Beck TC, Hedner U. Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma. Thromb Haemost 1991;66:464-7.
    • (1991) Thromb Haemost , vol.66 , pp. 464-467
    • Nordfang, O.1    Valentin, S.2    Beck, T.C.3    Hedner, U.4
  • 4
    • 0029073453 scopus 로고
    • Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced haemophilia A
    • Erhardtsen E, Ezban M, Madsen MT, Diness V, Glazer S, Hedner U, et al. Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced haemophilia A. Blood Coagul Fibrinolysis 1995;6:388-94.
    • (1995) Blood Coagul Fibrinolysis , vol.6 , pp. 388-394
    • Erhardtsen, E.1    Ezban, M.2    Madsen, M.T.3    Diness, V.4    Glazer, S.5    Hedner, U.6
  • 5
    • 84859794239 scopus 로고    scopus 로고
    • The extensive epitope overlap of the humanized monoclonal antibody mAb 2021 with the FXa binding site on K2 explains its neutralizing effect on TFPI
    • P-MO-111 abstract.
    • Breinholt J, Svensson LA, Hilden I, Krogh BO, Olsen OH, Pass J, et al. The extensive epitope overlap of the humanized monoclonal antibody mAb 2021 with the FXa binding site on K2 explains its neutralizing effect on TFPI. J Thromb Haemost 2011;9(Suppl. 2):P-MO-111 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Breinholt, J.1    Svensson, L.A.2    Hilden, I.3    Krogh, B.O.4    Olsen, O.H.5    Pass, J.6
  • 6
    • 84859806397 scopus 로고    scopus 로고
    • A monoclonal antibody mAb 2021 blocking tissue factor pathway inhibitor (TFPI) enhances haemostasis under haemophilia A-like conditions
    • P-MO-123 abstract
    • Sorensen BB, Hilden I, Petersen LC, Hermit MB, Petersen HH, Balling KW. A monoclonal antibody mAb 2021 blocking tissue factor pathway inhibitor (TFPI) enhances haemostasis under haemophilia A-like conditions. J Thromb Haemost 2011;9(Suppl. 2):P-MO-123 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Sorensen, B.B.1    Hilden, I.2    Petersen, L.C.3    Hermit, M.B.4    Petersen, H.H.5    Balling, K.W.6
  • 7
    • 84859798157 scopus 로고    scopus 로고
    • Blocking of tissue factor pathway inhibitor (TFPI) with mAb 2021 promotes thrombin generation in FVIII-deficient plasma
    • P-TU-137 abstract
    • Petersen LC, Hilden I, Bjoern S, Soerensen BB. Blocking of tissue factor pathway inhibitor (TFPI) with mAb 2021 promotes thrombin generation in FVIII-deficient plasma. J Thromb Haemost 2011;9(Suppl. 2):P-TU-137 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Petersen, L.C.1    Hilden, I.2    Bjoern, S.3    Soerensen, B.B.4
  • 8
    • 84859798156 scopus 로고    scopus 로고
    • Amonoclonal anti- TFPI antibody,mAb 2021, reduces bleeding in haemophilic rabbits after intravenous and subcutaneous administration
    • P-MO-120 abstract
    • Lauritzen B,HermitMB, Balling KW, AgersoeH, Sorensen BB,Hilden I. Amonoclonal anti- TFPI antibody,mAb 2021, reduces bleeding in haemophilic rabbits after intravenous and subcutaneous administration. J Thromb Haemost 2011;9(Suppl. 2):P-MO-120 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Lauritzen, B.1    Hermit, M.B.2    Balling, K.W.3    Agersoe, H.4    Sorensen, B.B.5    Hilden, I.6
  • 9
    • 84859802805 scopus 로고    scopus 로고
    • A monoclonal anti-TFPI antibody, mAb 2021, reduces an ongoing bleeding in haemophilic rabbits with a similar effect as rFVIIa
    • O-TU-113 abstract
    • Lauritzen B, Hilden I, Sorensen BB. A monoclonal anti-TFPI antibody, mAb 2021, reduces an ongoing bleeding in haemophilic rabbits with a similar effect as rFVIIa. J Thromb Haemost 2011;9(Suppl. 2):O-TU-113 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Lauritzen, B.1    Hilden, I.2    Sorensen, B.B.3
  • 10
    • 79956299608 scopus 로고    scopus 로고
    • Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor
    • Waters EK, Genga RM, Schwartz MC, Nelson JA, Schaub RG, Olson KA, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood 2011;117:5514-22.
    • (2011) Blood , vol.117 , pp. 5514-5522
    • Waters, E.K.1    Genga, R.M.2    Schwartz, M.C.3    Nelson, J.A.4    Schaub, R.G.5    Olson, K.A.6
  • 11
    • 84859806395 scopus 로고    scopus 로고
    • Inhibition of tissue factor inhibitor by ARC19499 (BAX499) improves ex vivo clotting in hemophilia patients
    • O-TU-028 abstract
    • Gorczyca M, Male C, Pabinger I, Reitter S, Knoebl P, McGinness KE, et al. Inhibition of tissue factor inhibitor by ARC19499 (BAX499) improves ex vivo clotting in hemophilia patients. J Thromb Haemost 2011;9(Suppl. 2):O-TU-028 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Gorczyca, M.1    Male, C.2    Pabinger, I.3    Reitter, S.4    Knoebl, P.5    McGinness, K.E.6
  • 12
    • 84859806396 scopus 로고    scopus 로고
    • Aptamer BAX499, a potent and specific inhibitor of TFPI, corrects hemostasis parameters of hemohilic blood
    • O-TU-076 abstract
    • Shenbagapriya P, Chandran NS, Mercy D, Aby A, Vikram M, Alok S. Aptamer BAX499, a potent and specific inhibitor of TFPI, corrects hemostasis parameters of hemohilic blood. J Thromb Haemost 2011;9(Suppl. 2):O-TU-076 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Shenbagapriya, P.1    Chandran, N.S.2    Mercy, D.3    Aby, A.4    Vikram, M.5    Alok, S.6
  • 13
    • 84859801631 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor aptamer as a potential drug for hemophilia treatment
    • O-MO-114 abstract
    • Butenas S, Gissel M, Orfeo T, Mann KG. Tissue factor pathway inhibitor aptamer as a potential drug for hemophilia treatment. J Thromb Haemost 2011;9(Suppl. 2): O-MO-114 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Butenas, S.1    Gissel, M.2    Orfeo, T.3    Mann, K.G.4
  • 14
    • 84883819993 scopus 로고    scopus 로고
    • Peptides binding to Kunitz domain 1 of tissue factor pathway inhibitor inhibit the interaction with factor Xa
    • O-MO-057 abstract
    • Dockal M, Fries M, Brandstetter J, Ludwiczek M, Kontaxis G, Prohaska K, et al. Peptides binding to Kunitz domain 1 of tissue factor pathway inhibitor inhibit the interaction with factor Xa. J Thromb Haemost 2011;9(Suppl. 2):O-MO-057 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Dockal, M.1    Fries, M.2    Brandstetter, J.3    Ludwiczek, M.4    Kontaxis, G.5    Prohaska, K.6
  • 15
    • 84859798155 scopus 로고    scopus 로고
    • Inhibition of tissue factor pathway inhibitor (TFPI) by small peptides protects FXa and enhances FXa and thrombin formation in model systems and in plasma
    • O-MO-112 abstract
    • DockalM, Thomassen CLGD, Heinzmann ACA, Duckers C, Hartmann R, Scheiflinger F, et al. Inhibition of tissue factor pathway inhibitor (TFPI) by small peptides protects FXa and enhances FXa and thrombin formation in model systems and in plasma. J Thromb Haemost 2011;9(Suppl. 2):O-MO-112 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Dockal, M.1    Thomassen, C.L.G.D.2    Heinzmann, A.C.A.3    Duckers, C.4    Hartmann, R.5    Scheiflinger, F.6
  • 16
    • 84859806393 scopus 로고    scopus 로고
    • Improvement of hemostasis in hemophilia by peptides inhibiting tissue factor pathway inhibitor
    • P-TU-129 abstract
    • Dockal M, Hartmann R, Polakowski T, Osterkamp F, Kammlander W, Panholzer E, et al. Improvement of hemostasis in hemophilia by peptides inhibiting tissue factor pathway inhibitor. J Thromb Haemost 2011;9(Suppl. 2):P-TU-129 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Dockal, M.1    Hartmann, R.2    Polakowski, T.3    Osterkamp, F.4    Kammlander, W.5    Panholzer, E.6
  • 19
    • 38349145384 scopus 로고    scopus 로고
    • Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A
    • Prasad S, Lillicrap D, Labelle A, Knappe S, Keller T, Burnett E, et al. Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A. Blood 2008;111:672-9.
    • (2008) Blood , vol.111 , pp. 672-679
    • Prasad, S.1    Lillicrap, D.2    Labelle, A.3    Knappe, S.4    Keller, T.5    Burnett, E.6
  • 21
    • 33847054740 scopus 로고    scopus 로고
    • A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia
    • Allen GA, Persson E, Campbell RA, Ezban M, Hedner U, Wolberg AS. A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia. Arterioscler Thromb Vasc Biol 2007;27: 683-9.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 683-689
    • Allen, G.A.1    Persson, E.2    Campbell, R.A.3    Ezban, M.4    Hedner, U.5    Wolberg, A.S.6
  • 22
    • 33947494621 scopus 로고    scopus 로고
    • Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A
    • DOI 10.1111/j.1365-2141.2007.06534.x
    • Sørensen B, Persson E, Ingerslev J. Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation inwhole blood from patientswith severe haemophilia A. Br J Haematol 2007;137:158-65. (Pubitemid 46474712)
    • (2007) British Journal of Haematology , vol.137 , Issue.2 , pp. 158-165
    • Sorensen, B.1    Persson, E.2    Ingerslev, J.3
  • 23
    • 69249216581 scopus 로고    scopus 로고
    • Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice
    • Holmberg H, Lauritzen B, Tranholm M, Ezban M. Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice. J Thromb Haemost 2009;7:1517-22.
    • (2009) J Thromb Haemost , vol.7 , pp. 1517-1522
    • Holmberg, H.1    Lauritzen, B.2    Tranholm, M.3    Ezban, M.4
  • 24
    • 84855374941 scopus 로고    scopus 로고
    • Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: A randomized controlled trial
    • De Paula EV, Kavakli K, Mahlangu J, Ayob Y, Lentz SR, Morfini M, et al. Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial. J Thromb Haemost 2012;10:81-9.
    • (2012) J Thromb Haemost , vol.10 , pp. 81-89
    • De Paula, E.V.1    Kavakli, K.2    Mahlangu, J.3    Ayob, Y.4    Lentz, S.R.5    Morfini, M.6
  • 26
    • 0037424297 scopus 로고    scopus 로고
    • Mutagenesis of the γ-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site
    • DOI 10.1074/jbc.M211629200
    • Harvey SB, StoneMD,MartinezMB,NelsestuenGL.Mutagenesis of the γ-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site. J Biol Chem 2003;278:8363-9. (Pubitemid 36800585)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8363-8369
    • Harvey, S.B.1    Stone, M.D.2    Martinez, M.B.3    Nelsestuen, G.L.4
  • 27
    • 84859794238 scopus 로고    scopus 로고
    • BAY 86-6150, a novel recombinant factor VIIa variant, has a significantly higher therapeutic index than eptacog alfa (activated) in rabbit bleeding and thrombosis models
    • O-TU-114 abstract
    • Sim DS, Koellnberger M, Gu JM, Bornaes C, Kragh M, Clausen SK, et al. BAY 86-6150, a novel recombinant factor VIIa variant, has a significantly higher therapeutic index than eptacog alfa (activated) in rabbit bleeding and thrombosis models. J Thromb Haemost 2011;9(Suppl. 2):O-TU-114 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Sim, D.S.1    Koellnberger, M.2    Gu, J.M.3    Bornaes, C.4    Kragh, M.5    Clausen, S.K.6
  • 28
    • 84859802803 scopus 로고    scopus 로고
    • Targeting factor VIIa to platelet receptors results in enhanced activity
    • O-TU-078 abstract
    • Salas J, Ashworth T, Kistanova E, Patel R, Sakorafas P, Pape B, et al. Targeting factor VIIa to platelet receptors results in enhanced activity. J Thromb Haemost 2011;9(Suppl. 2):O-TU-078 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Salas, J.1    Ashworth, T.2    Kistanova, E.3    Patel, R.4    Sakorafas, P.5    Pape, B.6
  • 29
    • 31544434253 scopus 로고    scopus 로고
    • Asoluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties
    • DOI 10.1182/blood-2005-07-2733
    • Huang X, Ding WQ, Vaught JL, Wolf RF, Morrissey JH, Harrison RG, et al. A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties. Blood 2006;107:980-6. (Pubitemid 43156295)
    • (2006) Blood , vol.107 , Issue.3 , pp. 980-986
    • Huang, X.1    Ding, W.-Q.2    Vaught, J.L.3    Wolf, R.F.4    Morrissey, J.H.5    Harrison, R.G.6    Lind, S.E.7
  • 31
    • 77955443085 scopus 로고    scopus 로고
    • Generation of a novel factor IX with augmented clotting activities in vitro and in vivo
    • Lin CN, Kao CY, Miao CH, Hamaguchi N, Wu HL, Shi GY, et al. Generation of a novel factor IX with augmented clotting activities in vitro and in vivo. J Thromb Haemost 2010;8:1773-83.
    • (2010) J Thromb Haemost , vol.8 , pp. 1773-1783
    • Lin, C.N.1    Kao, C.Y.2    Miao, C.H.3    Hamaguchi, N.4    Wu, H.L.5    Shi, G.Y.6
  • 32
    • 77955445478 scopus 로고    scopus 로고
    • FIX-Triple, a gain-of-function factor IX variant, improves haemostasis in mouse models without increased risk of thrombosis
    • Kao CY, Lin CN, Yu IS, Tao MH, Wu HL, Shi GY, et al. FIX-Triple, a gain-of-function factor IX variant, improves haemostasis in mouse models without increased risk of thrombosis. Thromb Haemost 2010;104:355-65.
    • (2010) Thromb Haemost , vol.104 , pp. 355-365
    • Kao, C.Y.1    Lin, C.N.2    Yu, I.S.3    Tao, M.H.4    Wu, H.L.5    Shi, G.Y.6
  • 33
    • 84855832171 scopus 로고    scopus 로고
    • Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice
    • Milanov P, Ivanciu L, Abriss D, Quade-Lyssy P, Miesbach W, Alesci S, et al. Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice. Blood 2012;119:602-11.
    • (2012) Blood , vol.119 , pp. 602-611
    • Milanov, P.1    Ivanciu, L.2    Abriss, D.3    Quade-Lyssy, P.4    Miesbach, W.5    Alesci, S.6
  • 34
    • 38349137399 scopus 로고    scopus 로고
    • Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies
    • Scheiflinger F, Dockal M, Rosing J, Kerschbaumer RJ. Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies. J Thromb Haemost 2008;6:315-22.
    • (2008) J Thromb Haemost , vol.6 , pp. 315-322
    • Scheiflinger, F.1    Dockal, M.2    Rosing, J.3    Kerschbaumer, R.J.4
  • 35
    • 84859806394 scopus 로고    scopus 로고
    • Synthetic peptides discovered by phage display enhance the activity of hFIXa in functional coagulation assays
    • O-TU-075 abstract
    • Thorn K, Toby G, Hsiao KC, Seidel S, Donnelly R, Rakhe S, et al. Synthetic peptides discovered by phage display enhance the activity of hFIXa in functional coagulation assays. J Thromb Haemost 2011;9(Suppl. 2):O-TU-075 abstract.
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 2
    • Thorn, K.1    Toby, G.2    Hsiao, K.C.3    Seidel, S.4    Donnelly, R.5    Rakhe, S.6
  • 37
    • 78650988916 scopus 로고    scopus 로고
    • Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro
    • Bunce MW, Toso R, Camire RM. Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro. Blood 2011;117: 290-8.
    • (2011) Blood , vol.117 , pp. 290-298
    • Bunce, M.W.1    Toso, R.2    Camire, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.