Inhibition of Ca 2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

Molecular Pain

Volumn 8, Issue , 2012, Pages

  Shirahama, Masafumi ^a   Ushio, Soichiro ^a   Egashira, Nobuaki ^a   Yamamoto, Shota ^a   Sada, Hikaru ^a   Masuguchi, Ken ^a   Kawashiri, Takehiro ^a   Oishi, Ryozo ^a  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; ELPLAT; KN 92; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; OXALIPLATIN; PROTEIN SERINE THREONINE KINASE INHIBITOR; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; BENZYLAMINE DERIVATIVE; NEUROLEPTIC AGENT; PHENOL DERIVATIVE; PIPERIDINE DERIVATIVE; PLATINUM COMPLEX; SULFONAMIDE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; HYPERALGESIA; LUMBAR SPINAL CORD; MALE; MOTOR COORDINATION; NONHUMAN; PAIN THRESHOLD; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ROTAROD TEST; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZYLAMINES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; HYPERALGESIA; MALE; ORGANOPLATINUM COMPOUNDS; PHENOLS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; TRIFLUOPERAZINE;

EID: 84859781643     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-26     Document Type: Article

References (26)

1. Saif MW, Reardon J. Management of oxaliplatin-induced peripheral neuropathy. Ther Clin Risk Manag 2005, 1:249-258. 1661634, 18360567.
2. Sakurai M, Egashira N, Kawashiri T, Yano T, Ikesue H, Oishi R. Oxaliplatin-induced neuropathy in the rat: Involvement of oxalate in cold hyperalgesia but not mechanical allodynia. Pain 2009, 147:165-174. 10.1016/j.pain.2009.09.003, 19782472.
3. Mihara Y, Egashira N, Sada H, Kawashiri T, Ushio S, Yano T, Ikesue H, Oishi R. Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. Mol Pain 2011, 7:8. 10.1186/1744-8069-7-8, 3033350, 21247499.
4. Womack MD, MacDermott AB, Jessell TM. Sensory transmitters regulate intracellular calcium in dorsal horn neurons. Nature 1988, 334:351-353. 10.1038/334351a0, 2455871.
5. Lisman J, Schulman H, Cline H. The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 2002, 3:175-190. 10.1038/nrn753, 11994750.
6. Dai Y, Wang H, Ogawa A, Yamanaka H, Obata K, Tokunaga A, Noguchi K. Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy. Eur J Neurosci 2005, 21:2467-2474. 10.1111/j.1460-9568.2005.04091.x, 15932604.
7. Chen Y, Luo F, Yang C, Kirkmire CM, Wang ZJ. Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice. J Pharmacol Exp Ther 2009, 330:650-659. 10.1124/jpet.109.152165, 2713096, 19478130.
8. Katano T, Nakazawa T, Nakatsuka T, Watanabe M, Yamamoto T, Ito S. Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain. Neuropharmacology 2010, 60:609-616.
9. Matsumura S, Kunori S, Mabuchi T, Katano T, Nakazawa T, Abe T, Watanabe M, Yamamoto T, Okuda-Ashitaka E, Ito S. Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472. Eur J Neurosci 2010, 32:798-810. 10.1111/j.1460-9568.2010.07348.x, 20722721.
10. Choi SS, Seo YJ, Shim EJ, Kwon MS, Lee JY, Ham YO, Suh HW. Involvement of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse formalin pain model. Brain Res 2006, 1108:28-38. 10.1016/j.brainres.2006.06.048, 16863646.
11. Luo F, Yang C, Chen Y, Shukla P, Tang L, Wang LX, Wang ZJ. Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II. J Pharmacol Exp Ther 2008, 325:267-275. 10.1124/jpet.107.132167, 18178903.
12. Prozialeck WC, Weiss B. Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships. J Pharmacol Exp Ther 1982, 222:509-516.
13. Sumi M, Kiuchi K, Ishikawa T, Ishii A, Hagiwara M, Nagatsu T, Hidaka H. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun 1991, 181:968-975. 10.1016/0006-291X(91)92031-E, 1662507.
14. Gao L, Blair LA, Marshall J. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun 2006, 345:1606-1610. 10.1016/j.bbrc.2006.05.066, 16730662.
15. Qu XX, Cai J, Li MJ, Chi YN, Liao FF, Liu FY, Wan Y, Han JS, Xing GG. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Exp Neurol 2009, 215:298-307. 10.1016/j.expneurol.2008.10.018, 19046970.
16. Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S. Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci 2005, 22:1445-1454. 10.1111/j.1460-9568.2005.04340.x, 16190898.
17. Wilson JA, Garry EM, Anderson HA, Rosie R, Colvin LA, Mitchell R, Fleetwood-Walker SM. NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists. Pain 2005, 117:421-432. 10.1016/j.pain.2005.07.005, 16150544.
18. Hardingham GE, Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci 2010, 11:682-696. 10.1038/nrn2911, 2948541, 20842175.
19. Yashiro K, Philpot BD. Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity. Neuropharmacology 2008, 55:1081-1094. 10.1016/j.neuropharm.2008.07.046, 2590778, 18755202.
20. Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg 2003, 97:1108-1116.
21. Ye XF, Lu Y, Zhang P, Liang JH. Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats. Eur J Pharmacol 2004, 486:265-271. 10.1016/j.ejphar.2004.01.002, 14985048.
22. Bhargava KP, Chandra OM. Tranquillizing and hypotensive activities of twelve phenothiazines. Br J Pharmacol Chemother 1964, 22:154-161. 1703905, 14126045.
23. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110. 10.1016/0304-3959(83)90201-4, 6877845.
24. Egashira N, Hirakawa S, Kawashiri T, Yano T, Ikesue H, Oishi R. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci 2010, 112:473-476. 10.1254/jphs.10012SC, 20308797.
25. Kawashiri T, Egashira N, Watanabe H, Ikegami Y, Hirakawa S, Mihara Y, Yano T, Ikesue H, Oishi R. Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model. Eur J Pain 2011, 15:344-350. 10.1016/j.ejpain.2010.08.006, 20829082.
26. Egashira N, Tanoue A, Higashihara F, Mishima K, Fukue Y, Takano Y, Tsujimoto G, Iwasaki K, Fujiwara M. V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze. Neurosci Lett 2004, 356:195-198. 10.1016/j.neulet.2003.11.050, 15036628.