Mexiletine reverses Oxaliplatin-Induced neuropathic pain in rats

Journal of Pharmacological Sciences

Volumn 112, Issue 4, 2010, Pages 473-476

  Egashira, Nobuaki ^a   Hirakawa, Shingo ^a   Kawashiri, Takehiro ^a   Yano, Takahisa ^a   Ikesue, Hiroaki ^a   Oishi, Ryozo ^a  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Mexiletine; Neuropathic pain; Oxaliplatin

Indexed keywords

LIDOCAINE; MEXILETINE; OXALIPLATIN;

ACUTE DRUG ADMINISTRATION; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; HYPERALGESIA; MALE; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; RAT; SPRAGUE DAWLEY RAT;

EID: 77951211682     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10012SC     Document Type: Article

References (14)

1. Pasetto LM, D'Andrea MR, Rossi E, Monfardini S. Oxaliplatinrelated neurotoxicity: how and why? Crit Rev Oncol Hematol. 2006;59:159-168.
2. Dejgard A, Petersen P, Kastrup J. Mexiletine for treatment of chronic painful diabetic neuropathy. Lancet. 1988;1:9-11.
3. Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. Vincristine-induced allodynia in the rat. Pain. 2001;93:69-76.
4. Yamamoto H, Shimoshige Y, Yamaji T, Murai N, Aoki T, Matsuoka N. Pharmacological characterization of standard analgesics on mechanical allodynia in streptozotocin-induced diabetic rats. Neuropharmacology. 2009;57:403-408.
5. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109-110.
6. Sakurai M, Egashira N, Kawashiri T, Yano T, Ikesue H, Oishi R. Oxaliplatin-induced neuropathy in the rat: involvement of oxalate in cold hyperalgesia but not mechanical allodynia. Pain. 2009; 147:165-174.
7. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55-63.
8. Flatters SJ, Bennett GJ. Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain. 2004; 109:150-161.
9. Tremont-Lukats IW, Challapalli V, McNicol ED, Lau J, Carr DB. Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis. Anesth Analg. 2005;101:1738-1749.
10. Ling B, Authier N, Balayssac D, Eschalier A, Coudore F. Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. Pain. 2007;128:225-234.
11. Asano K, Sameshima T, Shirasawa H, Hisamitsu T. Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus. J Pharm Pharmacol. 2003;55: 1365-1370.
12. Adelsberger H, Quasthoff S, Grosskreutz J, Lepier A, Eckel F, Lersch C. The chemotherapeutic oxaliplatin alters voltage-gated Na+ channel kinetics on rat sensory neurons. Eur J Pharmacol. 2000;406:25-32.
13. Grolleau F, Gamelin L, Boisdron-Celle M, Lapied B, Pelhate M, Gamelin E. A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol. 2001;85:2293-2297.
14. Black JA, Cummins TR, Plumpton C, Chen YH, Hormuzdiar W, Clare JJ, et al. Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. J Neurophysiol. 1999;82:2776-2785.