Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

Scientific Reports

Volumn 1, Issue , 2011, Pages

  Guillamot, María ^a   Manchado, Eusebio ^a   Chiesa, Massimo ^a   Gṕmez López, Gonzalo ^a   Pisano, David G ^a   Sacristán, María P ^b   Malumbres, Marcos ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CDC14B PROTEIN, MOUSE; DUAL SPECIFICITY PHOSPHATASE; PHOSPHATE; RNA POLYMERASE II;

ALLELE; ANIMAL; ARTICLE; BINDING SITE; CELL CULTURE; CELL CYCLE; CHEMISTRY; CYTOLOGY; EXON; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; METABOLISM; MITOSIS; MOUSE; PHOSPHORYLATION; TRANSCRIPTION INITIATION;

ALLELES; ANIMALS; BINDING SITES; CELL CYCLE; CELLS, CULTURED; DUAL-SPECIFICITY PHOSPHATASES; EPIGENESIS, GENETIC; EXONS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MITOSIS; PHOSPHATES; PHOSPHORYLATION; RNA POLYMERASE II; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84859772362     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00189     Document Type: Article

References (28)

1. Malumbres, M. & Barbacid, M. Mammalian cyclin-dependent kinases. Trends Biochem Sci 30, 630-641 (2005). (Pubitemid 41540083)
2. Stegmeier, F. & Amon, A. Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet 38, 203-232 (2004). (Pubitemid 40013728)
3. Queralt, E. & Uhlmann, F. Cdk-counteracting phosphatases unlock mitotic exit. Curr Opin Cell Biol 20, 661-668 (2008).
4. Vazquez-Novelle, M. D., Esteban, V., Bueno, A. & Sacristan, M. P. Functional homology among human and fission yeast Cdc14 phosphatases. J Biol Chem 280, 29144-29150 (2005). (Pubitemid 41161365)
5. Li, L., Ernsting, B. R., Wishart, M. J., Lohse, D. L. & Dixon, J. E. Afamily of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem 272, 29403-29406 (1997). (Pubitemid 27508017)
6. Schmitz, M. H. et al. Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol 12, 886-893 (2010).
7. Manchado, E. et al. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55alpha, delta phosphatase. Cancer Cell 18, 641-654 (2010).
8. Sacristan, M. P., Ovejero, S. & Bueno, A. Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G/M transition. Cell Cycle 10, 387-391 (2011).
9. Mocciaro, A. & Schiebel, E. Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci 123, 2867-2876 (2010).
10. Chiesa, M., Guillamot, M., Bueno, M. J. & Malumbres, M. The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway. Cell Cycle 10, 1607-1617 (2011).
11. Berdougo, E., Nachury, M. V., Jackson, P. K. & Jallepalli, P. V. The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle 7, 1184-1190 (2008). (Pubitemid 351749271)
12. Mocciaro, A. et al. Vertebrate cells genetically deficient for Cdc14A or Cdc14B retainDNAdamage checkpoint proficiency but are impaired inDNArepair. J Cell Biol 189, 631-639 (2010).
13. Wei, Z. et al. Early-onset aging and defective DNA damage response in Cdc14bdeficient mice. Mol Cell Biol 31, 1470-1477 (2011).
14. Vazquez-Novelle, M. D., Mailand, N., Ovejero, S., Bueno, A. & Sacristan, M. P. Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B. J Biol Chem 285, 40544-40553 (2010).
15. Tumurbaatar, I., Cizmecioglu, O., Hoffmann, I., Grummt, I. & Voit, R. Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS One 6, e14711 (2011).
16. Egloff, S. & Murphy, S. Cracking the RNA polymerase II CTD code. Trends Genet 24, 280-288 (2008).
17. Govind, C. K., Zhang, F., Qiu, H., Hofmeyer, K. & Hinnebusch, A. G. Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Mol Cell 25, 31-42 (2007). (Pubitemid 46049060)
18. Ginsburg, D. S., Govind, C. K. & Hinnebusch, A. G. NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Mol Cell Biol 29, 6473-6487 (2009).
19. Buratowski, S. Progression through the RNA polymerase II CTD cycle. Mol Cell 36, 541-546 (2009).
20. Brookes, E. & Pombo, A. Modifications of RNA polymerase II are pivotal in regulating gene expression states. EMBO Rep 10, 1213-1219 (2009).
21. Wu, J. Q. et al. PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol 11, 644-651 (2009).
22. Bembenek, J. & Yu, H. Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. J Biol Chem 276, 48237-48242 (2001).
23. Bassermann, F. et al. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damageresponse checkpoint. Cell 134, 256-267 (2008). (Pubitemid 352010329)
24. Garcia-Higuera, I. et al. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10, 802-811 (2008).
25. Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1, 222-231 (2001). (Pubitemid 33741897)
26. Buratowski, S. The CTD code. Nat Struct Biol 10, 679-680 (2003). (Pubitemid 37052403)
27. Palancade, B. & Bensaude, O. Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation. Eur J Biochem 270, 3859-3870 (2003). (Pubitemid 37193863)
28. Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545-15550 (2005). (Pubitemid 41528093)