Synthesis of 2-N-substituted benzothiazoles via domino condensation-hetero cyclization process, mediated by copper oxide nanoparticles under ligand-free conditions

Tetrahedron Letters

Volumn 53, Issue 20, 2012, Pages 2518-2521

  Satish, G ^a   Reddy, K Harsha Vardhan ^a   Ramesh, K ^a   Karnakar, K ^a   Nageswar, Y V D ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

2 N substituted benzothiazole; Carbon disulfide; CuO nanoparticles; Piperidine; Recyclability

Indexed keywords

CARBON DISULFIDE; COPPER OXIDE; DIMETHYL SULFOXIDE; LIGAND; NANOPARTICLE; PIPERIDINE; POTASSIUM HYDROXIDE; SOLVENT; THIAZOLE DERIVATIVE;

ARTICLE; CATALYST; CYCLIZATION; REACTION ANALYSIS; SUBSTITUTION REACTION;

EID: 84859762895     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.03.012     Document Type: Article

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26. 4. After removal of the solvent in vacuo, the residue was purified by silica-gel chromatography to give the desired benzothiazole. Experimental procedure for recovering of CuO nanoparticles: After work-up, the aqueous layer containing CuO nanoparticles was carefully centrifuged at 8000 rpm for 60 min and washed several times with water and acetone. The retrieved particles were oven dried at 80°C and used for the next cycle. Likewise, the recovered CuO nanoparticles were recyclable up to three cycles. The native and used CuO nanoparticles were analyzed by powder XRD and TEM analysis. As observed from the powder XRD and TEM studies the used CuO nanoparticles are intact in size and shape even after three cycles, as compared to the native ones. The powder XRD spectra of both used and native are comparable, thus confirming the intactness of the particles even after three cycles.
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