Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction

Gynecological Endocrinology

Volumn 28, Issue 5, 2012, Pages 370-374

  Pepene, Carmen Emanuela ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Androgens; Cell adhesion molecules; Drospirenone; Flow mediated vasodilatation; Insulin resistance; Metformin; Platelet endothelial cell adhesion molecule 1; Polycystic ovary syndrome

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; DROSPIRENONE PLUS ETHINYLESTRADIOL; INSULIN; LYMPHOCYTE ANTIGEN; METFORMIN; SEX HORMONE BINDING GLOBULIN; SOLUBLE PLATELET ENDOTHELIAL CELL ADHESION MOLECULE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTERIAL WALL THICKNESS; ARTERY BLOOD FLOW; ARTICLE; BODY WEIGHT; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CLINICAL ARTICLE; COLORIMETRY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM INJURY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; INSULIN RESISTANCE; LOW CALORY DIET; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RISK ASSESSMENT; SMOKING; TREATMENT DURATION; VASODILATATION;

ANDROSTENES; ANTIGENS, CD31; CASE-CONTROL STUDIES; ENDOTHELIUM, VASCULAR; ETHINYL ESTRADIOL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; POLYCYSTIC OVARY SYNDROME; REGRESSION ANALYSIS; REPRODUCTIVE CONTROL AGENTS; VASODILATION; YOUNG ADULT;

EID: 84859750431     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2011.632792     Document Type: Article

References (29)

1. Diamanti-Kandarakis E, Paterakis T, Alexandraki K, Piperi C, Aessopos A, Katsikis I, Katsilambros N, et al. Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin. Hum Reprod 2006;21:1426-1431.
2. Glintborg D, Andersen M. An update on the pathogenesis, inflammation, and metabolism in hirsutism and polycystic ovary syndrome. Gynecol Endocrinol 2010;26:281-296.
3. Arikan S, Akay H, Bahceci M, Tuzcu A, Gokalp D. The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function. Fertil Steril 2009;91:450-455.
4. Orio F Jr, Palomba S, Cascella T, De Simone B, Di Biase S, Russo T, Labella D, et al. Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89:4588-4593.
5. Kravariti M, Naka KK, Kalantaridou SN, Kazakos N, Katsouras CS, Makrigiannakis A, Paraskevaidis EA, et al. Predictors of endothelial dysfunction in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:5088-5095.
6. Mancini F, Cianciosi A, Reggiani GM, Facchinetti F, Battaglia C, de Aloysio D. Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: A pilot study. Fertil Steril 2009;91:2537-2544.
7. Wang Y, Sheibani N. PECAM-1 isoform-specific activation of MAPK/ERKs and small GTPases: Implications in inflammation and angiogenesis. J Cell Biochem 2006;98:451-468.
8. Martin J, Collot-Teixeira S, McGregor L, McGregor JL. The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. Curr Pharm Des 2007;13:1751-1759.
9. Blankenberg S, Barbaux S, Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis 2003;170:191-203.
10. Solowiej A, Biswas P, Graesser D, Madri JA. Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis. Am J Pathol 2003;162:953-962.
11. Gao C, Sun W, Christofidou-Solomidou M, Sawada M, Newman DK, Bergom C, Albelda SM, et al. PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. Blood 2003;102:169-179.
12. Cao G, Fehrenbach ML, Williams JT, Finklestein JM, Zhu JX, Delisser HM. Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice. Am J Pathol 2009;175:903-915.
13. Werner N, Wassmann S, Ahlers P, Kosiol S, Nickenig G. Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2006;26:112-116.
14. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar- Morreale HF, Futterweit W, Janssen OE, et al. Androgen Excess Society. Positions statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An Androgen Excess Society guideline. J Clin Endocrinol Metab 2006;91:4237-4245.
15. Pepene CE, Ilie IR, Marian I, Duncea I. Circulating osteoprotegerin and soluble receptor activator of nuclear factor ? B ligand in polycystic ovary syndrome: Relationships to insulin resistance and endothelial dysfunction. Eur J Endocrinol 2011;164:61-68.
16. Luque-Ramirez M, Mendieta-Azcona C, del Rey Sanchez JM, Maties M, Escobar-Morreale HF. Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: Influence of obesity and smoking. Eur J Endocrinol 2009;160:469-480.
17. Nasiek M, Kos-Kudla B, Ostrowska Z, Marek B, Kajdaniuk D, Sieminska L, Foltyn W. Plasma concentration of soluble intercellular adhesion molecule-1 in women with polycystic ovary syndrome. Gynecol Endocrinol 2004;19:208-215.
18. Gonzalez F, Rote NS, Minium J, Kirwan JP. Evidence of proatherogenic inflammation in polycystic ovary syndrome. Metab Clin Exp 2009;58:954-962.
19. Mohlig M, Spranger J, Osterhoff M, Ristow M, Pfeiffer AF, Schill T, Schlosser HW, et al. The polycystic ovary syndrome per se is not associated with increased chronic inflammation. Eur J Endocrinol 2004;150:525-532.
20. Okouchi M, Okayama N, Imai S, Omi H, Shimizu M, Fukutomi T, Itoh M. High insulin enhances neutrophil transendothelial migration through increasing surface expression of platelet endothelial cell adhesion molecule-1 via activation of mitogen activated protein kinase. Diabetologia 2002;45:1449-1456.
21. Okouchi M, Okayama N, Omi H, Imaeda K, Fukutomi T, Nakamura A, Itoh M. The antidiabetic agent, gliclazide, reduces high insulinenhanced neutrophil-transendothelial migration through direct effects on the endothelium. Diabetes Metab Res Rev 2004;20:232-238.
22. Death AK, McGrath KC, Sader MA, Nakhla S, Jessup W, Handelsman DJ, Celermajer DS. Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-?B-dependent pathway. Endocrinology 2004;145:1889-1897.
23. Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993;178:449-460.
24. Bogen S, Pak J, Garifallou M, Deng X, Muller WA. Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J Exp Med 1994;179:1059-1064.
25. Stevens HY, Melchior B, Bell KS, Yun S, Yeh JC, Frangos JA. PECAM-1 is a critical mediator of atherosclerosis. Dis Model Mech 2008;1:175-81; discussion 179.
26. Serebruany VL, Murugesan SR, Pothula A, Atar D, Lowry DR, O'Connor CM, Gurbel PA. Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy. Eur J Heart Fail 1999;1:243-249.
27. Romualdi D, Costantini B, Selvaggi L, Giuliani M, Cristello F, Macri F, Bompiani A, et al. Metformin improves endothelial function in normoinsulinemic PCOS patients: A new prospective. Hum Reprod 2008;23:2127-2133.
28. Bilgir O, Kebapcilar L, Taner C, Bilgir F, Kebapcilar A, Bozkaya G, Yildiz Y, et al. The effect of ethinylestradiol (EE)/cyproterone acetate (CA) and EE/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS). Intern Med 2009;48:1193-1199.
29. Seeger H, Wallwiener D, Mueck AO. Effects of drospirenone on cardiovascular markers in human aortic endothelial cells. Climacteric 2009;12:80-87.