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1
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75149152971
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Positive end-expiratory pressure
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This important review thoroughly discusses the rationale as well as the methods to titrate optimal PEEP levels in patients with ALI/ARDS
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Gattinoni L, Carlesso E, Brazzi L, et al. Positive end-expiratory pressure. Curr Opin Crit Care 2010; 16:39-44. This important review thoroughly discusses the rationale as well as the methods to titrate optimal PEEP levels in patients with ALI/ARDS.
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Curr Opin Crit Care
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Gattinoni, L.1
Carlesso, E.2
Brazzi, L.3
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2
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70350237010
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Meta-analysis: Ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury
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Putensen C, Theuerkauf N, Zinserling J, et al. Meta-analysis: Ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009; 151:566-576.
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Ann Intern Med
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Putensen, C.1
Theuerkauf, N.2
Zinserling, J.3
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3
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75149171452
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Ventilatory support for acute respiratory failure: New and ongoing pathophysiological, diagnostic and therapeutic developments
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Del Sorbo L, Slutsky AS. Ventilatory support for acute respiratory failure: New and ongoing pathophysiological, diagnostic and therapeutic developments. Curr Opin Crit Care 2010; 16:1-7.
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Curr Opin Crit Care
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Del Sorbo, L.1
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Ventilator-induced lung injury: From the bench to the bedside
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Tremblay LN, Slutsky AS. Ventilator-induced lung injury: From the bench to the bedside. Intensive Care Med 2006; 32:24-33. (Pubitemid 43039374)
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Intensive Care Medicine
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Tremblay, L.N.1
Slutsky, A.S.2
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5
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0343893748
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Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome The Acute Respiratory Distress Syndrome Network
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Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342:1301-1308.
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N Engl J Med
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6
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Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome
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DOI 10.1164/rccm.200607-915OC
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Terragni PP, Rosboch G, Tealdi A, et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2007; 175:160-166. (Pubitemid 46115087)
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American Journal of Respiratory and Critical Care Medicine
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Terragni, P.P.1
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Tealdi, A.3
Corno, E.4
Menaldo, E.5
Davini, O.6
Gandini, G.7
Herrmann, P.8
Mascia, L.9
Quintel, M.10
Slutsky, A.S.11
Gattinoni, L.12
Ranieri, V.M.13
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7
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3242703034
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Higher versus lower positive endexpiratory pressures in patients with the acute respiratory distress syndrome
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Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive endexpiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004; 351:327-336.
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N Engl J Med
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Brower, R.G.1
Lanken, P.N.2
MacIntyre, N.3
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Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: A randomized controlled trial
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DOI 10.1001/jama.299.6.637
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Meade MO, Cook DJ, Guyatt GH, et al. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. J Am Med Assoc 2008; 299:637-645. (Pubitemid 351252725)
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JAMA - Journal of the American Medical Association
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Meade, M.O.1
Cook, D.J.2
Guyatt, G.H.3
Slutsky, A.S.4
Arabi, Y.M.5
Cooper, D.J.6
Davies, A.R.7
Hand, L.E.8
Zhou, Q.9
Thabane, L.10
Austin, P.11
Lapinsky, S.12
Baxter, A.13
Russell, J.14
Skrobik, Y.15
Ronco, J.J.16
Stewart, T.E.17
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9
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39049161097
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Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: A randomized controlled trial
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DOI 10.1001/jama.299.6.646
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Mercat A, Richard JC, Vielle B, et al. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. J Am Med Assoc 2008; 299:646-655. (Pubitemid 351252726)
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JAMA - Journal of the American Medical Association
, vol.299
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Mercat, A.1
Richard, J.-C.M.2
Vielle, B.3
Jaber, S.4
Osman, D.5
Diehl, J.-L.6
Lefrant, J.-Y.7
Prat, G.8
Richecoeur, J.9
Nieszkowska, A.10
Gervais, C.11
Baudot, J.12
Bouadma, L.13
Brochard, L.14
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10
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77649221588
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How much PEEP in acute lung injury
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Rubenfeld GD. How much PEEP in acute lung injury. J Am Med Assoc 2010; 303:883-884.
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J Am Med Assoc
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Rubenfeld, G.D.1
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11
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79955603078
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Use of computed tomography scanning to guide lung recruitment and adjust positive-end expiratory pressure
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A recent and comprehensive review on the use of computed tomography scanning to titrate ventilator settings
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Pelosi P, Rocco PR, de Abreu MG. Use of computed tomography scanning to guide lung recruitment and adjust positive-end expiratory pressure. Curr Opin Crit Care 2011; 17:268-274. A recent and comprehensive review on the use of computed tomography scanning to titrate ventilator settings.
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(2011)
Curr Opin Crit Care
, vol.17
, pp. 268-274
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Pelosi, P.1
Rocco, P.R.2
De Abreu, M.G.3
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13
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78650413922
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Extrapolation from ten sections can make CT-based quantification of lung aeration more practicable
-
An important methodological study showing that the use of 10 slices combined with a simple trapezoidal interpolation procedure permits an accurate estimation of lung aeration. This technique will allow quantitative CT scanning at much lower radiation exposure and faster image analysis
-
Reske AW, Reske AP, Gast HA, et al. Extrapolation from ten sections can make CT-based quantification of lung aeration more practicable. Intensive Care Med 2010; 36:1836-1844. An important methodological study showing that the use of 10 slices combined with a simple trapezoidal interpolation procedure permits an accurate estimation of lung aeration. This technique will allow quantitative CT scanning at much lower radiation exposure and faster image analysis.
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(2010)
Intensive Care Med
, vol.36
, pp. 1836-1844
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Reske, A.W.1
Reske, A.P.2
Gast, H.A.3
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14
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33646115657
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Lung recruitment in patients with the acute respiratory distress syndrome
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Gattinoni L, Caironi P, Cressoni M, et al. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 2006; 354:1775-1786.
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(2006)
N Engl J Med
, vol.354
, pp. 1775-1786
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Gattinoni, L.1
Caironi, P.2
Cressoni, M.3
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15
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77749316982
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Lung opening and closing during ventilation of acute respiratory distress syndrome
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An important study in patients with ARDS, showing that -in the presence of high recruitability -the benefical impact of reducing intratidal alveolar opening and closing by increasing PEEP prevails over the effects of increasing alveolar strain
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Caironi P, Cressoni M, Chiumello D, et al. Lung opening and closing during ventilation of acute respiratory distress syndrome. Am J Respir Crit Care Med 2010; 181:578-586. An important study in patients with ARDS, showing that -in the presence of high recruitability -the benefical impact of reducing intratidal alveolar opening and closing by increasing PEEP prevails over the effects of increasing alveolar strain.
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(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 578-586
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Caironi, P.1
Cressoni, M.2
Chiumello, D.3
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16
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77649203752
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Higher vs. lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: Systematic review and meta-analysis
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Briel M, Meade M, Mercat A, et al. Higher vs. lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: Systematic review and meta-analysis. J Am Med Assoc 2010; 303:865-873.
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(2010)
J Am Med Assoc
, vol.303
, pp. 865-873
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Briel, M.1
Meade, M.2
Mercat, A.3
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17
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70349677952
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Tidal volume lower than 6 ml/kg enhances lung protection: Role of extracorporeal carbon dioxide removal
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Terragni PP, Del Sorbo L, Mascia L, et al. Tidal volume lower than 6 ml/kg enhances lung protection: Role of extracorporeal carbon dioxide removal. Anesthesiology 2009; 111:826-835.
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(2009)
Anesthesiology
, vol.111
, pp. 826-835
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Terragni, P.P.1
Del Sorbo, L.2
Mascia, L.3
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18
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0027024613
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Open up the lung and keep the lung open
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Lachmann B. Open up the lung and keep the lung open. Intensive Care Med 1992; 18:319-321.
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(1992)
Intensive Care Med
, vol.18
, pp. 319-321
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Lachmann, B.1
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19
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56749168884
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Recruitment maneuvers for acute lung injury: A systematic review
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Fan E, Wilcox ME, Brower RG, et al. Recruitment maneuvers for acute lung injury: A systematic review. Am J Respir Crit Care Med 2008; 178:1156-1163.
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(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1156-1163
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Fan, E.1
Wilcox, M.E.2
Brower, R.G.3
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20
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77950218712
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Lung morphology predicts response to recruitment maneuver in patients with acute respiratory distress syndrome
-
This study showed that lung morphology at ZEEP predicts the response to recruitment maneuvers. Patients with focal lung morphology were at substantial risk for significant hyperinflation during the recruitment maneuver, whereas lung recruitment was very limited. On the basis of these findings, the authors strongly advise a computed tomography assessment of the patient if lung morphology is not evident on chest radiograph
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Constantin JM, Grasso S, Chanques G, et al. Lung morphology predicts response to recruitment maneuver in patients with acute respiratory distress syndrome. Crit Care Med 2010; 38:1108-1117. This study showed that lung morphology at ZEEP predicts the response to recruitment maneuvers. Patients with focal lung morphology were at substantial risk for significant hyperinflation during the recruitment maneuver, whereas lung recruitment was very limited. On the basis of these findings, the authors strongly advise a computed tomography assessment of the patient if lung morphology is not evident on chest radiograph.
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(2010)
Crit Care Med
, vol.38
, pp. 1108-1117
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Constantin, J.M.1
Grasso, S.2
Chanques, G.3
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21
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79959657722
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Quantitative computed tomography in porcine lung injury with variable versus conventional ventilation: Recruitment and surfactant replacement
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By using quantitative computed tomography, this study showed that biologically variable ventilation resulted in significant recruitment, probably because of the intermittent high tidal volume breaths, or 'sighs'
-
Ruth Graham M, Goertzen AL, Girling LG, et al. Quantitative computed tomography in porcine lung injury with variable versus conventional ventilation: Recruitment and surfactant replacement. Crit Care Med 2011; 39:1721-1730. By using quantitative computed tomography, this study showed that biologically variable ventilation resulted in significant recruitment, probably because of the intermittent high tidal volume breaths, or 'sighs'.
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(2011)
Crit Care Med
, vol.39
, pp. 1721-1730
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Ruth Graham, M.1
Goertzen, A.L.2
Girling, L.G.3
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22
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79959652628
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Recruitability, recruitment, and tidal volume interactions: Is biologically variable ventilation a possible answeř
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Gattinoni L, Carlesso E, Cressoni M. Recruitability, recruitment, and tidal volume interactions: Is biologically variable ventilation a possible answeř Crit Care Med 2011; 39:1839-1840.
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(2011)
Crit Care Med
, vol.39
, pp. 1839-1840
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Gattinoni, L.1
Carlesso, E.2
Cressoni, M.3
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23
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79954570108
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Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury
-
Another study supporting the benefits of biologically variable ventilation using a remarkable technique combining dynamic CT and microsphere-based perfusion measurements
-
Carvalho AR, Spieth PM, Guldner A, et al. Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury. J Appl Physiol 2011; 110:1083-1092. Another study supporting the benefits of biologically variable ventilation using a remarkable technique combining dynamic CT and microsphere-based perfusion measurements.
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(2011)
J Appl Physiol
, vol.110
, pp. 1083-1092
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Carvalho, A.R.1
Spieth, P.M.2
Guldner, A.3
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24
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79955610444
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Positron emission tomography in ARDS: A new look at an old syndrome
-
Excellent review on the principles and use of positron emission tomography in ALI/ARDS
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Bellani G, Amigoni M, Pesenti A. Positron emission tomography in ARDS: A new look at an old syndrome. Minerva Anestesiol 2011; 77:439-447. Excellent review on the principles and use of positron emission tomography in ALI/ARDS.
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(2011)
Minerva Anestesiol
, vol.77
, pp. 439-447
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Bellani, G.1
Amigoni, M.2
Pesenti, A.3
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25
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78651423833
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Positron emission tomography: A tool for better understanding of ventilator-induced and acute lung injury
-
Excellent review on the principles and use of positron emission tomography in ALI/ARDS
-
Musch G. Positron emission tomography: A tool for better understanding of ventilator-induced and acute lung injury. Curr Opin Crit Care 2011; 17:7-12. Excellent review on the principles and use of positron emission tomography in ALI/ARDS.
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(2011)
Curr Opin Crit Care
, vol.17
, pp. 7-12
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Musch, G.1
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26
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77950956188
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Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen
-
An important PET/CT study illustrating the difference between aeration and ventilation
-
Wellman TJ, Winkler T, Costa EL, et al. Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen. J Nucl Med 2010; 51:646-653. An important PET/CT study illustrating the difference between aeration and ventilation.
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(2010)
J Nucl Med
, vol.51
, pp. 646-653
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Wellman, T.J.1
Winkler, T.2
Costa, E.L.3
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27
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67649766888
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Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-D-glucose PET/CT study
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Bellani G, Messa C, Guerra L, et al. Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-D-glucose PET/CT study. Crit Care Med 2009; 37:2216-2222.
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(2009)
Crit Care Med
, vol.37
, pp. 2216-2222
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Bellani, G.1
Messa, C.2
Guerra, L.3
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28
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79955490275
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Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury
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A landmark study using PET/CT to assess lung inflammation. This study showed a pronounced increase in lung inflammation at plateau pressures above 26-27cmH2O, reemphasizing that the concept of 'safe plateau pressures' needs reevaluation
-
Bellani G, Guerra L, Musch G, et al. Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med 2011; 183:1193-1199. A landmark study using PET/CT to assess lung inflammation. This study showed a pronounced increase in lung inflammation at plateau pressures above 26-27cmH2O, reemphasizing that the concept of 'safe plateau pressures' needs reevaluation.
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(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 1193-1199
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Bellani, G.1
Guerra, L.2
Musch, G.3
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29
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81355132770
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Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation
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A remarkable study revealing the full potential of PET/CT by assessing lung regional ventilation, perfusion and inflammation
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de Prost N, Costa EL, Wellman T, et al. Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation. J Appl Physiol 2011; 111:1249-1258. A remarkable study revealing the full potential of PET/CT by assessing lung regional ventilation, perfusion and inflammation.
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(2011)
J Appl Physiol
, vol.111
, pp. 1249-1258
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De Prost, N.1
Costa, E.L.2
Wellman, T.3
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30
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79955640279
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Lung impedance measurements to monitor alveolar ventilation
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Excellent review on electrical impedance tomography with a strong focus on methodological aspects and limitations of this technique
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Moerer O, Hahn G, Quintel M. Lung impedance measurements to monitor alveolar ventilation. Curr Opin Crit Care 2011; 17:260-267. Excellent review on electrical impedance tomography with a strong focus on methodological aspects and limitations of this technique.
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(2011)
Curr Opin Crit Care
, vol.17
, pp. 260-267
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Moerer, O.1
Hahn, G.2
Quintel, M.3
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31
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77952425944
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Impedance tomography as a new monitoring technique
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A comprehensive review on the current use of impedance tomography with a detailed discussion of different approaches to optimize ventilation
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Muders T, Luepschen H, Putensen C. Impedance tomography as a new monitoring technique. Curr Opin Crit Care 2010; 16:269-275. A comprehensive review on the current use of impedance tomography with a detailed discussion of different approaches to optimize ventilation.
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(2010)
Curr Opin Crit Care
, vol.16
, pp. 269-275
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Muders, T.1
Luepschen, H.2
Putensen, C.3
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32
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78651472672
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A new nonradiological method to assess potential lung recruitability: A pilot study in ALI patients
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Using a sophisticated technique incorporating electrical impedance data, the authors show how EIT-based approaches can be used to determine lung recruitability. As a high difference in potentially recruitable lung volume was observed, this technique may be useful to determine the need for recruitment maneuver and higher levels of PEEP
-
Lowhagen K, Lindgren S, Odenstedt H, et al. A new nonradiological method to assess potential lung recruitability: A pilot study in ALI patients. Acta Anaesthesiol Scand 2011; 55:165-174. Using a sophisticated technique incorporating electrical impedance data, the authors show how EIT-based approaches can be used to determine lung recruitability. As a high difference in potentially recruitable lung volume was observed, this technique may be useful to determine the need for recruitment maneuver and higher levels of PEEP.
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(2011)
Acta Anaesthesiol Scand
, vol.55
, pp. 165-174
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Lowhagen, K.1
Lindgren, S.2
Odenstedt, H.3
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33
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78651255186
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Regional intratidal gas distribution in acute lung injury and acute respiratory distress syndrome: Assessed by electric impedance tomography
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Lowhagen K, Lundin S, Stenqvist O. Regional intratidal gas distribution in acute lung injury and acute respiratory distress syndrome: Assessed by electric impedance tomography. Minerva Anestesiol 2010; 76:1024-1035.
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(2010)
Minerva Anestesiol
, vol.76
, pp. 1024-1035
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Lowhagen, K.1
Lundin, S.2
Stenqvist, O.3
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34
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33745828382
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Positive end-expiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery
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DOI 10.1111/j.1399-6576.2006.01079.x
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Erlandsson K, Odenstedt H, Lundin S, et al. Positive end-expiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery. Acta Anaesthesiol Scand 2006; 50:833-839. (Pubitemid 44034234)
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(2006)
Acta Anaesthesiologica Scandinavica
, vol.50
, Issue.7
, pp. 833-839
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Erlandsson, K.1
Odenstedt, H.2
Lundin, S.3
Stenqvist, O.4
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35
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77649305606
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PEEP titration guided by ventilation homogeneity: A feasibility study using electrical impedance tomography
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Zhao Z, Steinmann D, Frerichs I, et al. PEEP titration guided by ventilation homogeneity: A feasibility study using electrical impedance tomography. Crit Care 2010; 14:R8.
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(2010)
Crit Care
, vol.14
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Zhao, Z.1
Steinmann, D.2
Frerichs, I.3
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36
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Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre
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Dargaville PA, Rimensberger PC, Frerichs I. Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre. Intensive Care Med 2010; 36:1953-1961.
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Intensive Care Med
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Dargaville, P.A.1
Rimensberger, P.C.2
Frerichs, I.3
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37
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79960357037
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Effect of PEEP on regional ventilation during laparoscopic surgery monitored by electrical impedance tomography
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Karsten J, Luepschen H, Grossherr M, et al. Effect of PEEP on regional ventilation during laparoscopic surgery monitored by electrical impedance tomography. Acta Anaesthesiol Scand 2011; 55:878-886.
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(2011)
Acta Anaesthesiol Scand
, vol.55
, pp. 878-886
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Karsten, J.1
Luepschen, H.2
Grossherr, M.3
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78149236338
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Can heterogeneity in ventilation be good?
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Costa EL, Amato MB. Can heterogeneity in ventilation be good? Crit Care 2010; 14:134.
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Crit Care
, vol.14
, pp. 134
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Costa, E.L.1
Amato, M.B.2
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39
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80051488276
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Electrical impedance tomography measured at two thoracic levels can visualize the ventilation distribution changes at the bedside during a decremental positive end-expiratory pressure (PEEP) trial
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This study using simultaneous EIT measurements at a cranial and caudal thoracic level showed different behavior between caudal and cranial lung levels during a decremental PEEP trial. This work is helpful to better understand the differences in ventilation distribution throughout the lung
-
Bikker IG, Preis C, Egal M, et al. Electrical impedance tomography measured at two thoracic levels can visualize the ventilation distribution changes at the bedside during a decremental positive end-expiratory pressure (PEEP) trial. Crit Care 2011; 15:R193. This study using simultaneous EIT measurements at a cranial and caudal thoracic level showed different behavior between caudal and cranial lung levels during a decremental PEEP trial. This work is helpful to better understand the differences in ventilation distribution throughout the lung.
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(2011)
Crit Care
, vol.15
-
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Bikker, I.G.1
Preis, C.2
Egal, M.3
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40
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79960447066
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Changes in lung volume and ventilation during lung recruitment in high-frequency ventilated preterm infants with respiratory distress syndrome
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A very informative study showing the use of EIT in preterm infant in order to optimize lung recruitment during high-frequency oscillatory ventilation
-
Miedema M, de Jongh FH, Frerichs I, et al. Changes in lung volume and ventilation during lung recruitment in high-frequency ventilated preterm infants with respiratory distress syndrome. J Pediatr 2011; 159:199-205; e2. A very informative study showing the use of EIT in preterm infant in order to optimize lung recruitment during high-frequency oscillatory ventilation.
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J Pediatr 2011
, vol.159
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Miedema, M.1
De Jongh, F.H.2
Frerichs, I.3
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41
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79551537170
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Basic principles and current applications of lung ultrasonography in the intensive care unit
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A current review on lung ultrasonography, nicely explaining an illustrating the different lung signs, points, lines and patterns
-
Stefanidis K, Dimopoulos S, Nanas S. Basic principles and current applications of lung ultrasonography in the intensive care unit. Respirology 2011; 16:249-256. A current review on lung ultrasonography, nicely explaining an illustrating the different lung signs, points, lines and patterns.
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Respirology
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, pp. 249-256
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Stefanidis, K.1
Dimopoulos, S.2
Nanas, S.3
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42
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Lung ultrasound in critically ill patients: Comparison with bedside chest radiography
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Xirouchaki N, Magkanas E, Vaporidi K, et al. Lung ultrasound in critically ill patients: Comparison with bedside chest radiography. Intensive Care Med 2011; 37:1488-1493.
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Intensive Care Med
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Xirouchaki, N.1
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Vaporidi, K.3
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Ultrasound assessment of antibioticinduced pulmonary reaeration in ventilator-associated pneumonia
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Bouhemad B, Liu ZH, Arbelot C, et al. Ultrasound assessment of antibioticinduced pulmonary reaeration in ventilator-associated pneumonia. Crit Care Med 2010; 38:84-92.
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