The limits of reductionism in the life sciences

History and Philosophy of the Life Sciences

Volumn 33, Issue 4, 2011, Pages 453-476

  Kaiser, Marie I ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Decomposition; Part whole; Reductionism; Reductive explanation; Simplification

Indexed keywords

ARTICLE; BIOMEDICINE; MEDICAL RESEARCH; METHODOLOGY; PHILOSOPHY;

BIOLOGICAL SCIENCE DISCIPLINES; BIOMEDICAL RESEARCH; PHILOSOPHY;

EID: 84859745999     PISSN: 03919714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Ahn A.C., Tewari M., Poon C. and Phillips R.S., 2006a, "The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?", PLoS Medicine, 3: 709-713.
2. Ahn A.C., Tewari M., Poon C. and Phillips R.S., 2006b, "The Clinical Applications of a Systems Approach", PLoS Medicine, 3: 1-5.
3. Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P., 2008, Molecular Biology of the Cell, Fifth Edition, New York: Garland Science.
4. Ayala F.J., 1974, "Introduction", in: Ayala F.J., Dobzhansky T. (eds), Studies in the Philosophy of Biology, Berkeley: University of California Press, vii-xvi.
5. Bechtel W., Richardson R.C., 2010, Discovering Complexity: Decomposition and Localization as Strategies in Scientific Research, Cambridge: MIT Press.
6. Bickle J., 1998, Psychoneural Reduction: The New Wave, Cambridge: MIT Press.
7. Bickle J., 2006, "Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience", Synthese, 151: 411-434. (Pubitemid 44326852)
8. Bizzarri M., Cucina A., Conti F. and D'Anselmi F., 2008, "Beyond the Oncogene Paradigm: Understanding Complexity in Carcinogenesis", Acta Biotheoretica, 56: 173-196.
9. Brandon R.N., 1996, Concepts and Methods in Evolutionary Biology, Cambridge: Cambridge University Press.
10. Brigandt I., Love A., 2008, "Reductionism in Biology", The Stanford Encyclopedia of Philosophy (Fall 2008 Edition), Zalta, E.N. (ed.), URL = http://plato.stanford.edu/archives/fall2008/entries/reduction-biology/>.
11. Broad C.D., 1925, The Mind and Its Place in Nature, London: Routledge and Kegan Paul.
12. Buchanan A.V., Weiss K.M., Fullerton S.M., 2006, "Dissecting complex disease: the quest for the Philosopher's Stone?", International Journal of Epidemiology, 35: 562-571. (Pubitemid 43985537)
13. Campbell N.A. and Reece J.B., 2011, Biology, 9th Edition, Boston: Pearson.
14. Casadevall A., Fang F.C. and Pirofski L., 2011, "Microbial Virulence as an Emergent Property: Consequences and Opportunities", PLoS Pathogens, 7: 1-3.
15. Craver C.F., 2005, "Beyond Reduction: Mechanisms, Multifield Integration and the Unity of Neuroscience", Studies in the History and Philosophy of Biological and Biomedical Sciences, 36: 373-395. (Pubitemid 40757851)
16. Craver C.F., 2007, Explaining the Brain. Mechanisms and the Mosaic Unity of Neuroscience, Oxford: Clarendon Press.
17. Crick F.H.C., 1966, Of Molecules and Men, Seattle: University of Washington Press.
18. Chong L. and Ray L.B., 2002, "Whole-istic Biology", Science, 295: 1661. (Pubitemid 34202892)
19. Dawkins R., 1996, The Blind Watchmaker. Why the Evidence of Evolution Reveals a Universe Without Design, New York: Norton & Company.
20. Darden L., 2005, "Relations Among Fields: Mendelian, Cytological and Molecular Mechanisms", Studies in History and Philosophy of Biological and Biomedical Sciences, 36: 357-371.
21. Darden L. and Maull N., 1977, "Interfield Theories", Philosophy of Science, 44: 43-64.
22. Darden L. and Tabery J., 2010, "Molecular Biology", in: Zalta E.N. (ed.), The Stanford Encyclopedia of Philosophy, Fall 2010 Edition, URL = http://plato.stanford.edu/archives/fall2010/entries/molecular-biology/.
23. Dizadji-Bahmani F., Frigg R. and Hartmann S., 2010, "Who Is Afraid of Nagelian Reduction?", Erkenntnis, 73: 393-412.
24. Elser J.J. and Hamilton, A., 2007, "Stoichiometry and the New Biology: The future Is Now", PLoS Biology, 5: 1403-1405. (Pubitemid 47105329)
25. Fang F.C., Casadevall A., 2011, "Reductionistic and Holistic Science", Infection and Immunity, 79: 1401-1404.
26. Gallagher R. and Appenzeller T., 1999, "Beyond Reductionism", Science, 284: 79. (Pubitemid 29282049)
27. Glennan S.S., 2002, "Rethinking Mechanistic Explanation", Philosophy of Science, 69: 342-353.
28. Grizzi F. and Chiriva-Internati M., 2005, "The Complexity of Anatomical Systems", Theoretical Biology and Medical Modelling, 2: 26-34.
29. Huttemann A. and Love A.C., 2011, "Aspects of Reductive Explanation in Biological Science: Intrinsicality, Fundamentality, and Temporality", British Journal for Philosophy of Science, 62: 519-549.
30. Huston M., DeAngelis D. and Post W., 1988, "New Computer Models Unify Ecological Theory", BioScience, 38, 682-691.
31. Joyner M.J. and Pedersen B.K., 2011, "Ten Questions About Systems Biology", The Journal of Physiology: 1017-1030.
32. Kaiser M.I., forthcoming, "Why It Is Time To Move Beyond Nagelian Reduction", in: Dieks D., Gonzalez W.J., Hartmann S., Stoeltzner M., Weber M. (eds), Probabilities, Laws, and Structures (The Philosophy of Science in a European Perspective, Vol. 3), Heidelberg: Springer, 255-272.
33. Kauffman S.A., 1970, "Articulation of Parts Explanation in Biology and the Rational Search for them", Boston Studies in the Philosophy of Science, 8: 257-272.
34. Keller E.F., 2005, "The Century Beyond the Gene", Journal of Bioscience, 30: 3-10. (Pubitemid 40571494)
35. Kitano H., 2002, "Systems Biology: A Brief Overview", Science, 295: 1662-1664. (Pubitemid 34202893)
36. Kitcher P., 1984, "1953 and All That: A Tale of Two Sciences", Philosophical Review, 93: 335-373.
37. Levenstein S., 2009, "Against Reductionism", British Medical Journal, 339: 709.
38. Lidicker W.Z., 1988, "The Synergistic Effects of Reductionist and Holistic Approaches in Animal Ecology", OIKOS, 53: 278-281.
39. Machamer P., Darden L. and Craver CF., 2000, "Thinking about Mechanisms", Philosophy of Science, 67: 1-25.
40. Malaterre C., 2007, "Organicism and Reductionism in Cancer Research: Towards a Systemic Approach", International Studies in the Philosophy of Science, 21: 57-73.
41. Mayr E., 1988, "The Limits of Reductionism", Nature, 331: 475-476.
42. Mayr E., 2004, What Makes Biology Unique? Considerations on the Autonomy of a Scientific Discipline, Cambridge: Cambridge University Press.
43. Mazzocchi F., 2008, "Complexity in Biology. Exceeding the Limits of Reductionism and Determinism Using Complexity Theory", EMBO reports, 9: 10-14.
44. McClelland E.E., Bernhardt P. and Casadevall A., 2005, "Coping with Multiple Virulence Factors: Which Is Most Important?", PLoS Pathogens, 1: 287-288.
45. Mikkelson G.M., 2004, "Biological Diversity, Ecological Stability, and Downward Causation", in: Oksanen M., Pietarinen J. (eds), Philosophy and Biodiversity, Cambridge: Cambridge University Press, 119-129.
46. Mitchell S.D., 2009, Unsimple Truths. Science, Complexity, and Policy, Chicago/London: University of Chicago Press.
47. Nagel E., 1961, The Structure of Science. Problems in the Logic of Scientific Explanation, London: Routledge.
48. Powell K., 2004, "All Systems Go", The Journal of Cell Biology, 165: 299-303. (Pubitemid 38649905)
49. Rosenberg A., 2006, Darwinian Reductionism. Or, How to Stop Worrying and Love Molecular Biology, Cambridge: University of Chicago Press.
50. Roukos D.H., 2011, "Networks Medicine: From Reductionism to Evidence of Complex Dynamic Biomolecular Interactions", Pharmacogenomics, 12: 695-698.
51. Sarkar S., 1992, "Models of Reduction and Categories of Reductionism", Synthese, 91: 167-194.
52. Sarkar S., 1998, Genetics and Reductionism, Cambridge: Cambridge University Press.
53. Sarkar S., 2005a, Molecular Models of Life. Philosophical Papers on Molecular Biology, Cambridge: MIT Press.
54. Sarkar S., 2005b, "Ecology", The Stanford Encyclopedia of Philosophy (Spring 2009 Edition), Zalta E.N. (ed.), URL = .
55. Schaffner K.F., 1993, Discovery and Explanation in Biology and Medicine, Chicago/London: University of Chicago Press.
56. Schaffner K.F., 2006, "Reduction: The Cheshire Cat Problem and a Return to Roots", Synthese, 151: 377-402. (Pubitemid 44326850)
57. Schoener T.W., 1986, "Mechanistic Approaches to Community Ecology: A New Reductionism?", American Zoologist, 26: 81-106.
58. Service R.F., 1999, "Exploring the Systems Life", Science, 284: 80-83.
59. Sorger P.K., 2005, "A Reductionist's Systems Biology", Current Opinion in Cell Biology, 17: 9-11.
60. Soto A.M., Rubin B.S. and Sonnenschein C., 2009, "Interpreting endocrine disruption from an integrative biology perspective", Molecular and Cellular Endocrinology, 304: 3-7.
61. Soto A.M. and Sonnenschein C., 2005, "Emergentism as a Default: Cancer as a Problem of Tissue Organization", Journal of Bioscience, 30: 103-118. (Pubitemid 40571505)
62. Soto A.M. and Sonnenschein C., 2006, "Emergentism by Default: A View From the Bench", Synthese, 151: 361-376. (Pubitemid 44326849)
63. Van Regenmortel M.H.V., 2004, "Reductionism and Complexity in Molecular Biology", EMBO reports, 5: 1016-1020.
64. Venter J.C. et al., 2001, "The Sequence of the Human Genome", Science, 291: 1304-1348.
65. Weinberg R.A., 1998, One Renegade Cell: The Quest for the Origin of Cancer, New York: Basic Books.
66. Wimsatt W.C., 2007, Re-Engineering Philosophy for Limited Beings: Piecewise Approximations to Reality, Cambridge: Harvard University Press.