Corticoadrenal activity regulates in rat betaine-homocysteine S-methyltransferase expression with opposites effects in liver and kidney

Journal of Biosciences

Volumn 37, Issue 1, 2012, Pages 115-123

  Fridman, Osvaldo ^a,b,c   Morales, Analía V ^a   Bortoni, Laura E ^b   Turk Noceto, Paula C ^a   Prieto, Elio A ^a  

^a UNIVERSIDAD ABIERTA INTERAMERICANA   (Argentina)

^b Instituto de Oncologia Angel H Roffo   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Betaine; homocysteine; methylation; osmolyte

Indexed keywords

BETAINE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CORTICOSTEROID; METHYLPREDNISOLONE; PRIMER DNA;

ENZYME ACTIVITY; GENE EXPRESSION; METHYLATION; MODELING; RODENT;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BHMT GENE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE; GENE EXPRESSION REGULATION; KIDNEY; KIDNEY CORTEX; KIDNEY DISTAL TUBULE; LIVER; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SODIUM ABSORPTION; UPREGULATION; WATER ABSORPTION; ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALIA; RATTUS;

ADRENAL CORTEX HORMONES; ADRENALECTOMY; ANALYSIS OF VARIANCE; ANIMALS; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; BLOTTING, WESTERN; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KIDNEY; LIVER; MALE; METHYLPREDNISOLONE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84859740079     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-011-9171-5     Document Type: Article

References (40)

1. Adachi H, Hirai Y, Fujiura Y, Matsuoka H, Satoh A and Imaizumi T 2002 Plasma homocysteine levels and atherosclerosis in Japan: epidemiological study by use of carotid ultrasonography. Stroke 33 2177-2181 (Pubitemid 35014625)
2. Albert CM, Rifai N, Stampfer MJ and Ridker PM 2002 Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 105 2595-2599 (Pubitemid 34596034)
3. Ali R, Amlal H, Burnham CE and Soleimani M 2000 Glucocorticoids enhance the expression of the basolateral Na+:HCO3- cotransporter in renal proximal tubules. Kidney Int. 57 1063-1071 (Pubitemid 30434795)
4. Bagnasco S, Balaban R, Fales HM, Yang YM and Burg M 1986 Predominant osmotically active organic solutes in rat and rabbit renal medullas. J. Biol. Chem. 261 5872-5877 (Pubitemid 17207418)
5. Bailey MA, Mullins JJ and Kenyon CJ 2009 Mineralocorticoid and glucocorticoid receptors stimulate epithelium channel activity in a mouse model of Cushing syndrome. Hypertension 54 890-896
6. Bradford MM 1972 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 248-254
7. Bruno A, Carucci P, Cassader M, Cavallo-Perin P, Gruden G, Olivetti C and Pagano G 1994 Serum glucose, insulin and C-peptide response to oral glucose after intravenous administration of hydrocortisone and methylprednisolone in man. Eur. J. Clin. Pharmacol. 46 411-415 (Pubitemid 24199200)
8. Chen LH, Liu ML, Hwang HY, Chen LS, Korenberg J and Shane B 1997 Human methionine synthase. cDNA cloning, gene localization, and expression. J. Biol. Chem. 272 3628-3634
9. De Zwart FJ, Slow S, Payne RJ, Lever M, George PM, Gerrard JA and Chambers ST 2003 Glycine betaine and glycine betaine analogues in common foods. Food Chem. 83 197-204
10. Delgado-Reyes CV and Garrow TA 2005 High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 R182-R187 (Pubitemid 40023929)
11. Delgado-Reyes CV, Wallig MA and Garrow TA 2001 Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney. Arch. Biochem. Biophys. 393 184-186 (Pubitemid 32808374)
12. Duerre JA and Miller CH 1966 Preparation of L-homocysteine from L-homocysteine thiolactone. Anal. Biochem. 17 310-315
13. Finkelstein JD, Harris BJ, Martin JJ and Kyle WE 1982 Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem. Biophys. Res. Commun. 108 344-348
14. Finkelstein JD, Kyle WE and Harris BJ 1971 Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue. Arch. Biochem. Biophys. 146 84-92
15. Finkelstein JD and Martin JJ 1986 Methionine metabolism in mammals. Adaptation to methionine excess. J. Biol. Chem. 261 1582-1587 (Pubitemid 17204987)
16. Finkelstein JD and Mudd SH 1967 Trans-sulfuration in Mammals. The methionine sparing effect of cysteine. J. Biol. Chem. 242 873-880
17. Fischer LM, Scearce JA, Mar M-H, Patel JR, Blanchard RT, Macintosh BA, Busby MG and Zeisel SH 2005 Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level. J. Nutr. 135 826-829 (Pubitemid 40464112)
18. Gaeggeler HP, Gonzalez-Rodriguez E, Jaeger NF, Loffing-Cueni D, Norregaard R, Loffing J, Horisberger JD and Rossier BC 2005 Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line. J. Am. Soc. Nephrol. 16 878-891 (Pubitemid 41710298)
19. Garcia-Perez A and Burg MB 1991 Renal medullary osmolytes. Physiol. Rev. 71 1081-1115
20. Garrow TA 1996 Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J. Biol. Chem. 271 22831-22838 (Pubitemid 26304732)
21. Häussinger D 1996 The role of cellular hydration in the regulation of cell function. Biochem. J. 313 697-710 (Pubitemid 26050797)
22. Mangos GJ, Turner SW, Fraser TB and Whitworth JA 2000 The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat. J. Hypertens. 18 1849-1855
23. McKeever MP, Weir DG, Molloy A and Scott JM 1991 Betainehomocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin. Sci. 81 551-556
24. Millian NS and Garrow TA 1998 Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Arch. Biochem. Biophys. 356 93-98 (Pubitemid 28364359)
25. Ortiz PA and Garvin JL 2001 Intrarenal transport and vasoactive substances in hypertension. Hypertension 38 621-624
26. Park EI and Garrow TA 1999 Interaction between dietary methionine and methyl donor intake on rat liver betainehomocysteine methyltransferase gene expression and organization of the human gene. J. Biol. Chem. 274 7816-7824
27. Park EI, Renduchintala MS and Garrow TA 1997 Diet-induced changes in hepatic betaine-homocysteine methyltransferase activity are mediated by changes in the steady-state level of its mRNA. J. Nutr. Biochem. 8 541-545 (Pubitemid 27421345)
28. Quinkler M and Stewart PM 2003 Hypertension and the cortisolcortisone shuttle. J. Clin. Endocrinol. Metab. 88 2384-2392
29. Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME and Brosnan JT 2006 Effects of diabetes and insulin on betainehomocysteine S-methyltransferase expression in rat liver. Am. J. Physiol. 290 E933-E939
30. Schäfer C, Hoffmann L, Heldt K, Lornejad-Schäfer MR, Brauers G, Gehrmann T, Garrow TA, Häussinger D, Mayatepek E, Schwahn BC and Schliess F 2007 Osmotic regulation of betaine homocytine- S-methyltransferase expression in H4IIE rat hepatoma cells. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G1089-G1098 (Pubitemid 46557778)
31. Schliess F and Häussinger D 2002 The cellular hydration state: a critical determinant for cell death and survival. Biol. Chem. 383 577-583 (Pubitemid 34506294)
32. Sizeland PC, Chambers ST, Lever M, Bason LM and Robson RA 1995 Shortterm response of nonurea organic osmolytes in human kidney to a water load and water deprivation. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 268 F227-F233
33. Slow S and Garrow TA 2006 Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J. Nutr. 136 2279-2283 (Pubitemid 44329982)
34. Sunden SLF, Renduchintala MS, Park EI, Miklasz SD and Garrow TA 1997 Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch. Biochem. Biophys. 345 171-174 (Pubitemid 27374220)
35. Sundström J, Sullivan L, D'Agostino RB, Jacques PF, Selhub J, Rosenberg IH, Wilson PWF, Levy D and Vasan RS 2003 Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study. Hypertension 42 1100-1105 (Pubitemid 37549062)
36. Teng YW, Mehedint MG, Garrow TA and Zeisel SH 2011 Deletion of betaine-homocysteine s-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in Fatty liver and hepatocellular carcinomas. J. Biol. Chem. 286 36258-36267
37. Wehner F, Olsen H, Tinel H, Kinne-Saffran E and Kinne RKH 2003 Cell volume regulation: osmolytes, osmolyte transport and signal transduction. Rev. Physiol. Biochem. Pharmacol. 148 1-80
38. Zeisel SH and Blusztajn JK 1994 Choline and human nutrition. Annu. Rev. Nutr. 14 269-296 (Pubitemid 24261839)
39. Zeisel SH, Mar M-H, Howe JC and Holden JM 2003 Concentrations of choline-containing compounds and betaine in common foods. J. Nutr. 133 1302-1307 (Pubitemid 36548698)
40. Zhang J, Blusztajn JK and Zeisel SH 1992 Measurement of the formation of betaine aldehyde and betaine in rat livermitochondria by high pressure liquid chromatography-radioenzymatic assay. Biochim. Biophys. Acta 1117 333-339