-
1
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok, T. S.; Wu, Y. L.; Thongprasert, S.; Yang, C. H.; Chu, D. T.; Saijo, N.; Sunpaweravong, P.; Han, B.; Margono, B.; Ichinose, Y.; Nishiwaki, Y.; Ohe, Y.; Yang, J. J.; Chewaskulyong, B.; Jiang, H.; Duffield, E. L.; Watkins, C. L.; Armour, A. A.; Fukuoka, M. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361:947-957; 2009.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
Sunpaweravong, P.7
Han, B.8
Margono, B.9
Ichinose, Y.10
Nishiwaki, Y.11
Ohe, Y.12
Yang, J.J.13
Chewaskulyong, B.14
Jiang, H.15
Duffield, E.L.16
Watkins, C.L.17
Armour, A.A.18
Fukuoka, M.19
-
2
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo, M.; Inoue, A.; Kobayashi, K.; Sugawara, S.; Oizumi, S.; Isobe, H.; Gemma, A.; Harada, M.; Yoshizawa, H.: Kinoshita, I.; Fujita, Y.; Okinaga, S.; Hirano, H.; Yoshimori, K.; Harada, T.; Oqura, T.; Ando, M.; Miyazawa, H.; Tanaka, T.; Saijo, Y.; Haqiwara, K.; Morita, S.; Nukiwa, T. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362:2380-2388; 2010.
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
Gemma, A.7
Harada, M.8
Yoshizawa, H.9
Kinoshita, I.10
Fujita, Y.11
Okinaga, S.12
Hirano, H.13
Yoshimori, K.14
Harada, T.15
Oqura, T.16
Ando, M.17
Miyazawa, H.18
Tanaka, T.19
Saijo, Y.20
Haqiwara, K.21
Morita, S.22
Nukiwa, T.23
more..
-
3
-
-
17844390172
-
Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions
-
Pao, W.; Miller, V. A. Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions. J. Clin. Oncol. 23:2556-2568; 2005.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 2556-2568
-
-
Pao, W.1
Miller, V.A.2
-
4
-
-
58149218582
-
Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment
-
Chin, T. M.; Quinlan, M. P.; Singh, A.; Sequist, L. V.; Lynch, T. J.; Haber, D. A.; Sharma, S. V.; Settleman, J. Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment. Clin. Cancer Res. 14:6867-6876; 2008.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6867-6876
-
-
Chin, T.M.1
Quinlan, M.P.2
Singh, A.3
Sequist, L.V.4
Lynch, T.J.5
Haber, D.A.6
Sharma, S.V.7
Settleman, J.8
-
5
-
-
45749120442
-
Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy
-
Yang, C. H.; Yu, C. J.; Shih, J. Y.; Chang, Y. C.; Hu, F. C.; Tsai, M. C.; Chen, K. Y.; Lin, Z. Z.; Huang, C. J.; Shun, C. T.; Huang, C. L.; Bean, J.; Cheng, A. L.; Pao, W.; Yang, P. C. Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy. J. Clin. Oncol. 26:2745-2753; 2008.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2745-2753
-
-
Yang, C.H.1
Yu, C.J.2
Shih, J.Y.3
Chang, Y.C.4
Hu, F.C.5
Tsai, M.C.6
Chen, K.Y.7
Lin, Z.Z.8
Huang, C.J.9
Shun, C.T.10
Huang, C.L.11
Bean, J.12
Cheng, A.L.13
Pao, W.14
Yang, P.C.15
-
6
-
-
75749152586
-
Influence of first-line chemotherapy and EGFR mutations on second-line gefitinib in advanced non-small cell lung cancer
-
Wu, J. Y.; Yu, C. J.; Shih, J. Y.; Yang, C. H.; Yang, P. C. Influence of first-line chemotherapy and EGFR mutations on second-line gefitinib in advanced non-small cell lung cancer. Lung Cancer 67:348-354; 2010.
-
(2010)
Lung Cancer
, vol.67
, pp. 348-354
-
-
Wu, J.Y.1
Yu, C.J.2
Shih, J.Y.3
Yang, C.H.4
Yang, P.C.5
-
7
-
-
57349172709
-
Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib
-
Servidei, T.; Riccardi, A.; Mozzetti, S.; Ferlini, C.; Riccardi, R. Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib. Int. J. Cancer 123:2939-2949; 2008.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 2939-2949
-
-
Servidei, T.1
Riccardi, A.2
Mozzetti, S.3
Ferlini, C.4
Riccardi, R.5
-
8
-
-
14644435131
-
Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines
-
Dai, Q.; Ling, Y. H.; Lia, M.; Zou, Y. Y.; Kroog, G.; Iwata, K. K.; Perez-Soler, R. Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines. Clin. Cancer Res. 11:1572-1578; 2005.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1572-1578
-
-
Dai, Q.1
Ling, Y.H.2
Lia, M.3
Zou, Y.Y.4
Kroog, G.5
Iwata, K.K.6
Perez-Soler, R.7
-
9
-
-
0023130372
-
Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemo-sensitivity testing
-
Carmichael, J.; DeGraff, W. G.; Gazdar, A. F.; Minna, J. D.; Mitchell, J. B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemo-sensitivity testing. Cancer Res. 47:936-942; 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 936-942
-
-
Carmichael, J.1
DeGraff, W.G.2
Gazdar, A.F.3
Minna, J.D.4
Mitchell, J.B.5
-
10
-
-
72449198117
-
The role of MET activation in determining the sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors
-
Rho, J. K.; Choi, Y. J.; Lee, J. K.; Ryoo, B. Y.; Na, I. I.; Yang, S. H.; Lee, S. S.; Kim, C. H.; Yoo, Y. D.; Lee, J. C. The role of MET activation in determining the sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors. Mol. Cancer Res. 7:1736-1743; 2009.
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 1736-1743
-
-
Rho, J.K.1
Choi, Y.J.2
Lee, J.K.3
Ryoo, B.Y.4
Na, I.I.5
Yang, S.H.6
Lee, S.S.7
Kim, C.H.8
Yoo, Y.D.9
Lee, J.C.10
-
11
-
-
4444332925
-
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
-
Cappuzzo, F.; Magrini, E.; Ceresoli, G. L.; Bartolini, S.; Rossi, E.; Ludovini, V.; Gregorc, V.; Ligorio, C.; Cancellieri, A.; Damiani, S.; Spreafico, A.; Paties, C. T.; Lombardo, L.; Calandri, C.; Bellezza, G.; Tonato, M.; Crinò, L. Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J. Natl. Cancer Inst. 96:1133-1141; 2004.
-
(2004)
J. Natl. Cancer Inst.
, vol.96
, pp. 1133-1141
-
-
Cappuzzo, F.1
Magrini, E.2
Ceresoli, G.L.3
Bartolini, S.4
Rossi, E.5
Ludovini, V.6
Gregorc, V.7
Ligorio, C.8
Cancellieri, A.9
Damiani, S.10
Spreafico, A.11
Paties, C.T.12
Lombardo, L.13
Calandri, C.14
Bellezza, G.15
Tonato, M.16
Crinò, L.17
-
12
-
-
33749435816
-
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
-
Engelman, J. A.; Mukohara, T.; Zejnullahu, K.; Lifshits, E.; Borraaposs, A. M.; Gale, C. M.; Naumov, G. N.; Yeap, B. Y.; Jarrell, E.; Sun, J.; Tracy, S.; Zhao, X.; Heymach, J. V.; Johnson, B. E.; Cantley, L. C.; Jänne, P. A. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J. Clin. Invest. 116:2695-2706; 2006.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2695-2706
-
-
Engelman, J.A.1
Mukohara, T.2
Zejnullahu, K.3
Lifshits, E.4
Borraaposs, A.M.5
Gale, C.M.6
Naumov, G.N.7
Yeap, B.Y.8
Jarrell, E.9
Sun, J.10
Tracy, S.11
Zhao, X.12
Heymach, J.V.13
Johnson, B.E.14
Cantley, L.C.15
Jänne, P.A.16
-
13
-
-
34250898667
-
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt
-
Yamasaki, F.; Johansen, M. J.; Zhang, D.; Krishnamurthy, S.; Felix, E.; Bartholomeusz, C.; Aquilar, R. J.; Kurisu, K.; Mills, G. B.; Hortobagyi, G. N.; Ueno, N. T. Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt. Cancer Res. 67:5779-5788; 2007.
-
(2007)
Cancer Res.
, vol.67
, pp. 5779-5788
-
-
Yamasaki, F.1
Johansen, M.J.2
Zhang, D.3
Krishnamurthy, S.4
Felix, E.5
Bartholomeusz, C.6
Aquilar, R.J.7
Kurisu, K.8
Mills, G.B.9
Hortobagyi, G.N.10
Ueno, N.T.11
-
14
-
-
26644449670
-
The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
-
She, Q. B.; Solit, D. B.; Ye, Q.; O'Reilly, K. E.; Lobo, J.; Rosen, N. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 8:287-297; 2005.
-
(2005)
Cancer Cell
, vol.8
, pp. 287-297
-
-
She, Q.B.1
Solit, D.B.2
Ye, Q.3
O'Reilly, K.E.4
Lobo, J.5
Rosen, N.6
-
15
-
-
38049097938
-
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
-
McDermott, U.; Sharma, S. V.; Dowell, L.; Greninger, P.; Montagut, C.; Lamb, J.; Archibald, H.; Raudales, R.; Tam, A.; Lee, D.; Rothenberg, S. M.; Supko, J. G.; Sordella, R.; Ulkus, L. E.; Iafrate, A. J.; Maheswaran, S.; Njauw, C. N.; Tsao, H.; Drew, L.; Hanke, J. H.; Ma, X. J.; Erlander, M. G.; Gray, N. S.; Haber, D. A.; Settleman, J. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc. Natl. Acad. Sci. USA 104:19936-19941; 2007.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19936-19941
-
-
McDermott, U.1
Sharma, S.V.2
Dowell, L.3
Greninger, P.4
Montagut, C.5
Lamb, J.6
Archibald, H.7
Raudales, R.8
Tam, A.9
Lee, D.10
Rothenberg, S.M.11
Supko, J.G.12
Sordella, R.13
Ulkus, L.E.14
Iafrate, A.J.15
Maheswaran, S.16
Njauw, C.N.17
Tsao, H.18
Drew, L.19
Hanke, J.H.20
Ma, X.J.21
Erlander, M.G.22
Gray, N.S.23
Haber, D.A.24
Settleman, J.25
more..
-
16
-
-
65949086609
-
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
-
Sos, M. L.; Koker, M.; Weir, B. A.; Heynck, S.; Rabinovsky, R.; Zander, T.; Seeger, J. M.; Weiss, J.; Fischer, F.; Frommolt, P.; Michel, K.; Peifer, M.; Mermel, C.; Girard, L.; Peyton, M.; Gazdar, A. F.; Minna, J. D.; Garraway, L. A.; Kashkar, H.; Pao, W.; Meyerson, M.; Thomas, R. K. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 69:3256-3261; 2009.
-
(2009)
Cancer Res.
, vol.69
, pp. 3256-3261
-
-
Sos, M.L.1
Koker, M.2
Weir, B.A.3
Heynck, S.4
Rabinovsky, R.5
Zander, T.6
Seeger, J.M.7
Weiss, J.8
Fischer, F.9
Frommolt, P.10
Michel, K.11
Peifer, M.12
Mermel, C.13
Girard, L.14
Peyton, M.15
Gazdar, A.F.16
Minna, J.D.17
Garraway, L.A.18
Kashkar, H.19
Pao, W.20
Meyerson, M.21
Thomas, R.K.22
more..
-
17
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
Gong, Y.; Somwar, R.; Politi, K.; Balak, M.; Chmielecki, J.; Jiang, X.; Pao, W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 4: e294; 2007.
-
(2007)
PLoS Med.
, vol.4
-
-
Gong, Y.1
Somwar, R.2
Politi, K.3
Balak, M.4
Chmielecki, J.5
Jiang, X.6
Pao, W.7
-
18
-
-
34547204635
-
Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in asso ciation with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lines
-
Ling, Y. H.; Li, T.; Yuan, Z.; Haigentz, Jr., M.; Weber, T. K.; Perez-Soler, R. Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in asso ciation with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lines. Mol. Pharmacol. 72:248-258; 2007.
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 248-258
-
-
Ling, Y.H.1
Li, T.2
Yuan, Z.3
Haigentz Jr., M.4
Weber, T.K.5
Perez-Soler, R.6
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