Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Macia, Laurence ^a,b   Tsai, Vicky Wang Wei ^c   Nguyen, Amy D ^a   Johnen, Heiko ^c   Kuffner, Tamara ^c   Shi, Yan Chuan ^a   Lin, Shu ^a   Herzog, Herbert ^a,c   Brown, David A ^c   Breit, Samuel N ^c   Sainsbury, Amanda ^a,c,d  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH DIFFERENTIATION FACTOR 15;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; ENERGY EXPENDITURE; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPOPHAGIA; LEAN BODY WEIGHT; LIPID DIET; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PHYSICAL ACTIVITY; PROTEIN FUNCTION; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; EATING; FEMALE; GENETICS; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ANIMALS; BODY WEIGHT; EATING; FEMALE; GLUCOSE; GROWTH DIFFERENTIATION FACTOR 15; MICE; MICE, TRANSGENIC; OBESITY;

EID: 84859733519     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034868     Document Type: Article

References (25)

1. Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, et al. (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci U S A 94: 11514-11519.
2. Breit SN, Johnen H, Cook AD, Tsai VW, Mohammad MG, et al. (2011) The TGF-beta superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth factors 29: 187-195.
3. Brown DA, Breit SN, Buring J, Fairlie WD, Bauskin AR, et al. (2002) Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet 359: 2159-2163.
4. Brown DA, Hance KW, Rodgers CJ, Sansbury LB, Albert PS, et al. (2011) Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15): a potential screening tool for the prevention of colon cancer? Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
5. Wiklund FE, Bennet AM, Magnusson PK, Eriksson UK, Lindmark F, et al. (2010) Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality. Aging cell 9: 1057-1064.
6. Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, et al. (2007) Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med 13: 1333-1340.
7. Dostalova I, Roubicek T, Bartlova M, Mraz M, Lacinova Z, et al. (2009) Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet. European journal of endocrinology/European Federation of Endocrine Societies 161: 397-404.
8. Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, et al. (2009) Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology 150: 1688-1696.
9. Galic S, Oakhill JS, Steinberg GR, (2010) Adipose tissue as an endocrine organ. Molecular and cellular endocrinology 316: 129-139.
10. Karczewska-Kupczewska M, Kowalska I, Nikolajuk A, Adamska A, Otziomek E, et al. (2012) Hyperinsulinemia acutely increases serum macrophage inhibitory cytokine-1 concentration in anorexia nervosa and obesity. Clinical endocrinology 76: 46-50.
11. Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, et al. (2011) Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling. Cell metabolism 14: 67-79.
12. Zhang L, Macia L, Turner N, Enriquez RF, Riepler SJ, et al. (2010) Peripheral neuropeptide Y Y1 receptors regulate lipid oxidation and fat accretion. International journal of obesity 34: 357-373.
13. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, et al. (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454: 1000-1004.
14. van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, et al. (1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. The Journal of clinical investigation 99: 385-390.
15. Sainsbury A, Zhang L, (2010) Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit. Molecular and cellular endocrinology 316: 109-119.
16. Yaswen L, Diehl N, Brennan MB, Hochgeschwender U, (1999) Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nature medicine 5: 1066-1070.
17. Patel HR, Qi Y, Hawkins EJ, Hileman SM, Elmquist JK, et al. (2006) Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes 55: 3091-3098.
18. Marino JS, Xu Y, Hill JW, (2011) Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends in endocrinology and metabolism: TEM 22: 275-285.
19. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, et al. (2007) Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. FEBS letters 581: 1131-1136.
20. Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B, (1994) Intracerebroventricular administration of neuropeptide Y to normal rats has divergent effects on glucose utilization by adipose tissue and skeletal muscle. Diabetes 43: 764-769.
21. Bergen HT, Mizuno T, Taylor J, Mobbs CV, (1999) Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain research 851: 198-203.
22. Lin S, Storlien LH, Huang XF, (2000) Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain research 875: 89-95.
23. Ferrannini E, (1988) The theoretical bases of indirect calorimetry: a review. Metabolism: clinical and experimental 37: 287-301.
24. Frayn KN, (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. Journal of applied physiology: respiratory, environmental and exercise physiology 55: 628-634.
25. McLean JA, Tobin G, (1987) Animal and Human Calorimetry Cambridge University Press.