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Volumn 15, Issue 42, 2011, Pages

Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): A systematic review and economic analysis

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; AROMATASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HORMONE RECEPTOR; LAPATINIB; LETROZOLE; TRASTUZUMAB; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; NITRILE; QUINAZOLINE DERIVATIVE; TRIAZOLE DERIVATIVE;

EID: 84856333750     PISSN: 13665278     EISSN: 20464924     Source Type: Journal    
DOI: 10.3310/hta15420     Document Type: Review
Times cited : (25)

References (114)
  • 1
    • 65649087098 scopus 로고    scopus 로고
    • Breast cancer: Understanding sensitivity and resistance to chemotherapy and targeted therapies to aid in personalised medicine
    • Germano S, O'Driscoll L. Breast cancer: understanding sensitivity and resistance to chemotherapy and targeted therapies to aid in personalised medicine. Curr Cancer Drug Targets 2009;9:398-418.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 398-418
    • Germano, S.1    O'Driscoll, L.2
  • 2
    • 84856355178 scopus 로고    scopus 로고
    • Cancer Research UK, URL:, (accessed: 6 September 2010)
    • Cancer Research UK. Breast cancer-risk factors. 2010. URL: http://info.cancerresearchuk.org/cancerstats/types/breast/riskfactors/ (accessed: 6 September 2010).
    • (2010) Breast cancer-risk factors
  • 3
    • 40549096421 scopus 로고    scopus 로고
    • Taxanes for the adjuvant treatment of early breast cancer: Systematic review and economic evaluation
    • Ward S, Simpson E, Davis S, Hind D, Rees A, Wilkinson A. Taxanes for the adjuvant treatment of early breast cancer: systematic review and economic evaluation. Health Technol Assess 2007;11(40).
    • (2007) Health Technol Assess , vol.11 , Issue.40
    • Ward, S.1    Simpson, E.2    Davis, S.3    Hind, D.4    Rees, A.5    Wilkinson, A.6
  • 6
    • 0037123341 scopus 로고    scopus 로고
    • Endogenous sex hormones and breast cancer in postmenopausal women: Reanalysis of nine prospective studies
    • Endogenous Hormones Breast Cancer Collaborative Group
    • Endogenous Hormones Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94:606-16.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 606-616
  • 8
    • 64249099411 scopus 로고    scopus 로고
    • American Joint Committee on Cancer, 7th edn. Chicago, IL: Springer
    • American Joint Committee on Cancer. AJCC cancer staging manual. 7th edn. Chicago, IL: Springer; 2009.
    • (2009) AJCC cancer staging manual
  • 9
    • 0003412927 scopus 로고    scopus 로고
    • International Union Against Cancer, 7th edn. New York, NY: Wiley-Liss
    • International Union Against Cancer. TNM classification of malignant tumours. 7th edn. New York, NY: Wiley-Liss; 2009.
    • (2009) TNM classification of malignant tumours
  • 10
    • 75749092296 scopus 로고    scopus 로고
    • Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    • Dowsett M, Cuzick J, Ingle J, Coates A, Forbes J, Bliss J, et al. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol 2010;28:509-18.
    • (2010) J Clin Oncol , vol.28 , pp. 509-518
    • Dowsett, M.1    Cuzick, J.2    Ingle, J.3    Coates, A.4    Forbes, J.5    Bliss, J.6
  • 11
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group
    • Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365:1687-717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 12
    • 84889758912 scopus 로고    scopus 로고
    • Cancer Research UK, URL:, (accessed 6 September 2010)
    • Cancer Research UK. Predicted improvements in breast cancer survival cancer research UK. 2010. URL: www.cancerhelp.org.uk/about-cancer/cancer-questions/predictedimprovements-in-breast-cancer-survival (accessed 6 September 2010).
    • (2010) Predicted improvements in breast cancer survival cancer research UK
  • 13
    • 49249107696 scopus 로고    scopus 로고
    • Prognostic factors in metastatic breast cancer: Successes and challenges toward individualized therapy
    • Andreopoulou E, Hortobagyi GN. Prognostic factors in metastatic breast cancer: successes and challenges toward individualized therapy. J Clin Oncol 2008;26:3660-2.
    • (2008) J Clin Oncol , vol.26 , pp. 3660-3662
    • Andreopoulou, E.1    Hortobagyi, G.N.2
  • 14
    • 0027299707 scopus 로고
    • The influence of chemotherapy on survival after recurrence in breast-cancer-a population-based study of patients treated in the 1950s, 1960s and 1970s
    • Cold S, Jensen NV, Brincker H, Rose C. The influence of chemotherapy on survival after recurrence in breast-cancer-a population-based study of patients treated in the 1950s, 1960s and 1970s. Eur J Cancer 1993;29:1146-52.
    • (1993) Eur J Cancer , vol.29 , pp. 1146-1152
    • Cold, S.1    Jensen, N.V.2    Brincker, H.3    Rose, C.4
  • 15
    • 0010524401 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (NICE), NICE technology appraisal guidance. No. 34, URL:, (accessed 26 January 2010)
    • National Institute for Health and Clinical Excellence (NICE). Guidance on the use of trastuzumab for the treatment of advanced breast cancer. NICE technology appraisal guidance. No.34. 2002. URL: www.nice.org.uk/nicemedia/pdf/TA107guidance.pdf (accessed 26 January 2010).
    • (2002) Guidance on the use of trastuzumab for the treatment of advanced breast cancer
  • 16
    • 84861816827 scopus 로고    scopus 로고
    • Cancer Research UK, URL:, (accessed 18 August 2011)
    • Cancer Research UK. Breast cancer-UK incidence statistics. 2010. URL: http://info.cancerresearchuk.org/cancerstats/types/breast/incidence/ (accessed 18 August 2011).
    • (2010) Breast cancer-UK incidence statistics
  • 18
    • 29844450886 scopus 로고    scopus 로고
    • Origins of socio-economic inequalities in cancer survival: A review
    • Woods LM, Rachet B, Coleman MP. Origins of socio-economic inequalities in cancer survival: a review. Ann Oncol 2006;17:5-19.
    • (2006) Ann Oncol , vol.17 , pp. 5-19
    • Woods, L.M.1    Rachet, B.2    Coleman, M.P.3
  • 21
    • 25144453930 scopus 로고    scopus 로고
    • Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab
    • Dybdal N, Leiberman G, Anderson S, McCune B, Bajamonde A, Cohen R, et al. Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab. Breast Cancer Res Treat 2005;93:3-11.
    • (2005) Breast Cancer Res Treat , vol.93 , pp. 3-11
    • Dybdal, N.1    Leiberman, G.2    Anderson, S.3    McCune, B.4    Bajamonde, A.5    Cohen, R.6
  • 23
    • 62549164935 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (NICE), NICE clinical guideline. No. 81, URL:, (accessed 26 January 2010)
    • National Institute for Health and Clinical Excellence (NICE). Advanced breast cancer: diagnosis and treatment. NICE clinical guideline. No. 81. 2009. URL: www.nice.org.uk/Guidance/CG81 (accessed 26 January 2010).
    • (2009) Advanced breast cancer: Diagnosis and treatment
  • 24
    • 77449084889 scopus 로고    scopus 로고
    • The impact of breast cancer among Canadian women: Disability and productivity
    • Quinlan E, Thomas-Maclean R, Hack T, Kwan W, Miedema B, Tatemichi S, et al. The impact of breast cancer among Canadian women: disability and productivity. Work 2009;34:285-96.
    • (2009) Work , vol.34 , pp. 285-296
    • Quinlan, E.1    Thomas-McLean, R.2    Hack, T.3    Kwan, W.4    Miedema, B.5    Tatemichi, S.6
  • 26
    • 57149142075 scopus 로고    scopus 로고
    • Quality of life in patients with breast cancer before and after diagnosis: An eighteen months follow-up study
    • Montazeri A, Vahdaninia M, Harirchi I, Ebrahimi M, Khaleghi F, Jarvandi S. Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study. BMC Cancer 2008;8:330.
    • (2008) BMC Cancer , vol.8 , pp. 330
    • Montazeri, A.1    Vahdaninia, M.2    Harirchi, I.3    Ebrahimi, M.4    Khaleghi, F.5    Jarvandi, S.6
  • 28
    • 25844453682 scopus 로고    scopus 로고
    • British Medical Association and Royal Pharmaceutical Society of Great Britain, No. 59, March 2010. London: BMA and RPS
    • British Medical Association and Royal Pharmaceutical Society of Great Britain. British national formulary. No. 59, March 2010. London: BMA and RPS; 2010.
    • (2010) British national formulary
  • 31
    • 84889749093 scopus 로고    scopus 로고
    • Pharmaceutical Field
    • URL:, (accessed 14 July 2010)
    • Pharmaceutical Field. Further indication for tyverb approved. 2010. URL: www.pharmafield.co.uk/news/2010/06/further-indication-for-tyverb-approved (accessed 14 July 2010).
    • (2010) Further indication for tyverb approved
  • 32
    • 61749084637 scopus 로고    scopus 로고
    • Management of cardiac health in trastuzumab-treated patients with breast cancer: Updated United Kingdom National Cancer Research Institute recommendations for monitoring
    • Jones AL, Barlow M, Barrett-Lee PJ, Canney PA, Gilmour IM, Robb SD, et al. Management of cardiac health in trastuzumab-treated patients with breast cancer: updated United Kingdom National Cancer Research Institute recommendations for monitoring. Br J Cancer 2009;100:684-92.
    • (2009) Br J Cancer , vol.100 , pp. 684-692
    • Jones, A.L.1    Barlow, M.2    Barrett-Lee, P.J.3    Canney, P.A.4    Gilmour, I.M.5    Robb, S.D.6
  • 34
    • 48149100019 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (NICE), Technology appraisal No. TA112, URL:, (accessed 26 January 2010)
    • National Institute for Health and Clinical Excellence (NICE). Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer. Technology appraisal No. TA112. 2006. URL: www.nice.org.uk/TA112 (accessed 26 January 2010).
    • (2006) Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
  • 35
    • 34247253317 scopus 로고    scopus 로고
    • Non-standard management of breast cancer increases with age in the UK: A population based cohort of women greater than or equal to 65 years
    • Lavelle K, Todd C, Moran A, Howell A, Bundred N, Campbell M. Non-standard management of breast cancer increases with age in the UK: a population based cohort of women greater than or equal to 65 years. Br J Cancer 2007;96:1197-203.
    • (2007) Br J Cancer , vol.96 , pp. 1197-1203
    • Lavelle, K.1    Todd, C.2    Moran, A.3    Howell, A.4    Bundred, N.5    Campbell, M.6
  • 36
    • 2442504773 scopus 로고    scopus 로고
    • Stage and treatment variation with age in postmenopausal women with breast cancer: Compliance with guidelines
    • Wyld L, Garg DK, Kumar ID, Brown H, Reed MWR. Stage and treatment variation with age in postmenopausal women with breast cancer: compliance with guidelines. Br J Cancer 2004;90:1486-91.
    • (2004) Br J Cancer , vol.90 , pp. 1486-1491
    • Wyld, L.1    Garg, D.K.2    Kumar, I.D.3    Brown, H.4    Reed, M.W.R.5
  • 40
    • 5044221416 scopus 로고    scopus 로고
    • Combination of direct and indirect evidence in mixed treatment comparisons
    • Lu G, Ades AE. Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med 2004;23:3105-24.
    • (2004) Stat Med , vol.23 , pp. 3105-3124
    • Lu, G.1    Ades, A.E.2
  • 45
    • 73249114287 scopus 로고    scopus 로고
    • Trastuzumab-refractory HER2-positive metastatic breast cancer-use of tanespimycin, a novel Hsp90 inhibitor
    • Morris P, Modi S. Trastuzumab-refractory HER2-positive metastatic breast cancer-use of tanespimycin, a novel Hsp90 inhibitor. Am J Pediatr Hematol Oncol 2008;7.
    • (2008) Am J Pediatr Hematol Oncol , vol.7
    • Morris, P.1    Modi, S.2
  • 46
    • 1842530209 scopus 로고    scopus 로고
    • Inhibition of ErbB1 and ErbB2 by lapatinib ditosylate, a dual kinase inhibitor: Promising activity in pretreated advanced breast cancer
    • Maung K, O'Shaughnessy JA. Inhibition of ErbB1 and ErbB2 by lapatinib ditosylate, a dual kinase inhibitor: promising activity in pretreated advanced breast cancer. Clin Breast Cancer 2004;4:398-400.
    • (2004) Clin Breast Cancer , vol.4 , pp. 398-400
    • Maung, K.1    O'Shaughnessy, J.A.2
  • 47
    • 33947242929 scopus 로고    scopus 로고
    • Trastuzumab prolongs progression-free survival in patients with hormone-sensitive and HER2-overexpressing metastatic breast cancer
    • Ranganathan A, Moore Z, O'Shaughnessy JA. Trastuzumab prolongs progression-free survival in patients with hormone-sensitive and HER2-overexpressing metastatic breast cancer. Clin Breast Cancer 2007;7:450-1.
    • (2007) Clin Breast Cancer , vol.7 , pp. 450-451
    • Ranganathan, A.1    Moore, Z.2    O'Shaughnessy, J.A.3
  • 48
    • 62149092260 scopus 로고    scopus 로고
    • Lapatinib (tykerb) plus letrozole (femara) or letrozole alone for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Arteaga C. Lapatinib (tykerb) plus letrozole (femara) or letrozole alone for postmenopausal hormone receptor-positive metastatic breast cancer. P and T 2009;34:102.
    • (2009) P and T , vol.34 , pp. 102
    • Johnston, S.1    Arteaga, C.2
  • 49
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen J Jr, Pivot X, Lichinitser M, Sadeghi S, Dieras V, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27:5538-46.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3    Lichinitser, M.4    Sadeghi, S.5    Dieras, V.6
  • 50
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
    • Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009;27:5529-37.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    McKey, J.R.2    Clemens, M.R.3    Bapsy, P.P.4    Vaid, A.5    Wardley, A.6
  • 51
    • 77649100030 scopus 로고    scopus 로고
    • Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer
    • Schwarzberg LS, Franco SX, Florance A, O'Rourke L, Maltzman J, Johnston SRD. Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer. Oncologist 2010;15:122-9.
    • (2010) Oncologist , vol.15 , pp. 122-129
    • Schwarzberg, L.S.1    Franco, S.X.2    Florance, A.3    O'Rourke, L.4    Maltzman, J.5    Johnston, S.R.D.6
  • 52
    • 77949735163 scopus 로고    scopus 로고
    • Letrozole in combination with trastuzumab is superior to letrozole monotherapy as first line treatment in patients with hormone-receptor-positive, HER2-positive metastatic breast cancer (MBC)-results of the eLEcTRA Trial
    • Huober J, Fasching P, Paepke S, Kubista E, Barsoum M, Wallwiener D, et al. Letrozole in combination with trastuzumab is superior to letrozole monotherapy as first line treatment in patients with hormone-receptor-positive, HER2-positive metastatic breast cancer (MBC)-results of the eLEcTRA Trial. Cancer Res 2009;69:4094.
    • (2009) Cancer Res , vol.69 , pp. 4094
    • Huober, J.1    Fasching, P.2    Paepke, S.3    Kubista, E.4    Barsoum, M.5    Wallwiener, D.6
  • 53
    • 46449113024 scopus 로고    scopus 로고
    • Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
    • Gomez HL, Doval DC, Chavez MA, Ang PC-S, Aziz Z, Nag S, et al. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008;26:2999-3005.
    • (2008) J Clin Oncol , vol.26 , pp. 2999-3005
    • Gomez, H.L.1    Doval, D.C.2    Chavez, M.A.3    Ang, P.C.-S.4    Aziz, Z.5    Nag, S.6
  • 54
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
    • Cameron D, Casey M, Press M, Lindquist D, Pienkowski T, Romieu C, et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008;112:533-43.
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3    Lindquist, D.4    Pienkowski, T.5    Romieu, C.6
  • 56
    • 34250370236 scopus 로고    scopus 로고
    • Committee for Medicinal Products for Human Use, URL:, (accessed 22 July 2010)
    • Committee for Medicinal Products for Human Use. Guideline on the evaluation of anticancer medicinal products in man. 2005. URL: www.tga.gov.au/docs/pdf/euguide/ewp/020595enrev3.pdf (accessed 22 July 2010).
    • (2005) Guideline on the evaluation of anticancer medicinal products in man
  • 57
    • 67649990278 scopus 로고    scopus 로고
    • Issues in using progression-free survival when evaluating oncology products
    • Fleming TR, Rothmann MD, Lu HL. Issues in using progression-free survival when evaluating oncology products. J Clin Oncol 2009;27:2874-80.
    • (2009) J Clin Oncol , vol.27 , pp. 2874-2880
    • Fleming, T.R.1    Rothmann, M.D.2    Lu, H.L.3
  • 58
    • 61649098633 scopus 로고    scopus 로고
    • Progression-free survival and time to progression as primary end points in advanced breast cancer: Often used, sometimes loosely defined
    • Saad ED, Katz A. Progression-free survival and time to progression as primary end points in advanced breast cancer: often used, sometimes loosely defined. Ann Oncol 2009;20:460-4.
    • (2009) Ann Oncol , vol.20 , pp. 460-464
    • Saad, E.D.1    Katz, A.2
  • 59
    • 71949120744 scopus 로고    scopus 로고
    • Lapatinib plus letrozole compared with letrozole alone as first-line therapy in hormone receptor-positive HER2+ metastatic breast cancer (MBC): A quality-of-life (QOL) analysis
    • abstr 1039
    • Sherif B, Sherrill B, Amonkar M, Wu Y, Maltzman J, O'Rourke L, et al. Lapatinib plus letrozole compared with letrozole alone as first-line therapy in hormone receptor-positive HER2+ metastatic breast cancer (MBC): a quality-of-life (QOL) analysis. J Clin Oncol 2009;27:abstr 1039.
    • (2009) J Clin Oncol , vol.27
    • Sherif, B.1    Sherrill, B.2    Amonkar, M.3    Wu, Y.4    Maltzman, J.5    O'Rourke, L.6
  • 60
    • 0001015983 scopus 로고
    • Correcting for non-compliance in randomized trials using rank preserving structural failure time models
    • Robins JM, Tsiatis AA. Correcting for non-compliance in randomized trials using rank preserving structural failure time models. Comm Stat Theor 1991;20:2609-31.
    • (1991) Comm Stat Theor , vol.20 , pp. 2609-2631
    • Robins, J.M.1    Tsiatis, A.A.2
  • 61
    • 0027536734 scopus 로고
    • A method for the analysis of randomized trials with compliance information: An application to the multiple risk factor intervention trial
    • Mark SD, Robins JM. A method for the analysis of randomized trials with compliance information: an application to the multiple risk factor intervention trial. Control Clin Trials 1993;14:79-97.
    • (1993) Control Clin Trials , vol.14 , pp. 79-97
    • Mark, S.D.1    Robins, J.M.2
  • 65
    • 0033864536 scopus 로고    scopus 로고
    • Correcting for noncompliance and dependent censoring in an AIDS clinical trial with inverse probability of censoring weighted (IPCW) log-rank tests
    • Robins J, Finkelstein D. Correcting for noncompliance and dependent censoring in an AIDS clinical trial with inverse probability of censoring weighted (IPCW) log-rank tests. Biometrics 2000;56:779-88.
    • (2000) Biometrics , vol.56 , pp. 779-788
    • Robins, J.1    Finkelstein, D.2
  • 66
    • 0037106050 scopus 로고    scopus 로고
    • Estimating a treatment effect in survival studies in which patients switch treatment
    • Branson M, Whitehead J. Estimating a treatment effect in survival studies in which patients switch treatment. Stat Med 2002;21:2449-63.
    • (2002) Stat Med , vol.21 , pp. 2449-2463
    • Branson, M.1    Whitehead, J.2
  • 67
    • 1142287524 scopus 로고    scopus 로고
    • Parametric randomization-based methods for correcting for treatment changes in the assessment of the causal effect of treatment
    • Walker A, White I, Babiker A. Parametric randomization-based methods for correcting for treatment changes in the assessment of the causal effect of treatment. Stat Med 2004;23:571-90.
    • (2004) Stat Med , vol.23 , pp. 571-590
    • Walker, A.1    White, I.2    Babiker, A.3
  • 68
    • 0034669435 scopus 로고    scopus 로고
    • Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the tamoxifen or arimidex randomized group efficacy and tolerability study
    • Bonneterre J, Thürlimann B, Robertson JF, Krzakowski M, Mauriac L, Koralewski P, et al. Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the tamoxifen or arimidex randomized group efficacy and tolerability study. J Clin Oncol 2000;18:3748-57.
    • (2000) J Clin Oncol , vol.18 , pp. 3748-3757
    • Bonneterre, J.1    Thürlimann, B.2    Robertson, J.F.3    Krzakowski, M.4    Mauriac, L.5    Koralewski, P.6
  • 69
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial
    • Nabholtz JM, Buzdar A, Pollak M, Harwin W, Burton G, Mangalik A, et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. J Clin Oncol 2000;18:3758-67.
    • (2000) J Clin Oncol , vol.18 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.2    Pollak, M.3    Harwin, W.4    Burton, G.5    Mangalik, A.6
  • 70
    • 0031054095 scopus 로고    scopus 로고
    • A phase III trial comparing anastrozole (1 and 10 milligrams), a potent and selective aromatase inhibitor, with megestrol acetate in postmenopausal women with advanced breast carcinoma. Arimidex Study Group
    • Buzdar AU, Jones SE, Vogel CL, Wolter J, Plourde P, Webster A. A phase III trial comparing anastrozole (1 and 10 milligrams), a potent and selective aromatase inhibitor, with megestrol acetate in postmenopausal women with advanced breast carcinoma. Arimidex Study Group. Cancer 1997;79:730-9.
    • (1997) Cancer , vol.79 , pp. 730-739
    • Buzdar, A.U.1    Jones, S.E.2    Vogel, C.L.3    Wolter, J.4    Plourde, P.5    Webster, A.6
  • 71
    • 9244245282 scopus 로고    scopus 로고
    • A randomised trial comparing two doses of the new selective aromatase inhibitor anastrozole (Arimidex) with megestrol acetate in postmenopausal patients with advanced breast cancer
    • Jonat W, Howell A, Blomqvist C, Eiermann W, Winblad G, Tyrrell C, et al. A randomised trial comparing two doses of the new selective aromatase inhibitor anastrozole (Arimidex) with megestrol acetate in postmenopausal patients with advanced breast cancer. Eur J Cancer 1996;32:404-12.
    • (1996) Eur J Cancer , vol.32 , pp. 404-412
    • Jonat, W.1    Howell, A.2    Blomqvist, C.3    Eiermann, W.4    Winblad, G.5    Tyrrell, C.6
  • 72
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar M, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998;17:2815-34.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.1    Torri, V.2    Stewart, L.3
  • 73
    • 0030793120 scopus 로고    scopus 로고
    • The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials
    • Bucher H, Guyatt G, Griffith L, Walter S. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epidemiol 1997;50:683-91.
    • (1997) J Clin Epidemiol , vol.50 , pp. 683-691
    • Bucher, H.1    Guyatt, G.2    Griffith, L.3    Walter, S.4
  • 75
    • 61349184544 scopus 로고    scopus 로고
    • Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: A network metaanalysis
    • Puhan M, Bachmann L, Kleijnen J, ter Riet G, Kessels A. Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network metaanalysis. BMC Med 2009;7:2.
    • (2009) BMC Med , vol.7 , pp. 2
    • Puhan, M.1    Bachmann, L.2    Kleijnen, J.3    ter Riet, G.4    Kessels, A.5
  • 76
    • 34948836781 scopus 로고    scopus 로고
    • Letrozole in advanced breast cancer: The PO25 trial
    • Mouridsen HT. Letrozole in advanced breast cancer: the PO25 trial. Breast Cancer Res Treat 2007;105:19-29.
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 19-29
    • Mouridsen, H.T.1
  • 77
    • 0035879215 scopus 로고    scopus 로고
    • Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate
    • Buzdar A, Douma J, Davidson N, Elledge R, Morgan M, Smith R, et al. Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol 2001;19:3357-66.
    • (2001) J Clin Oncol , vol.19 , pp. 3357-3366
    • Buzdar, A.1    Douma, J.2    Davidson, N.3    Elledge, R.4    Morgan, M.5    Smith, R.6
  • 78
    • 0031943424 scopus 로고    scopus 로고
    • Letrozole, a new oral aromatase inhibitor for advanced breast cancer: Double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate
    • Dombernowsky P, Smith I, Falkson G, Leonard R, Panasci L, Bellmunt J, et al. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol 1998;16:453-61.
    • (1998) J Clin Oncol , vol.16 , pp. 453-461
    • Dombernowsky, P.1    Smith, I.2    Falkson, G.3    Leonard, R.4    Panasci, L.5    Bellmunt, J.6
  • 79
    • 0033736549 scopus 로고    scopus 로고
    • Exemestane improves survival compared with megoestrol acetate in postmenopausal patients with advanced breast cancer who have failed on tamoxifen. Results of a double-blind randomised phase III trial
    • Kaufmann M, Bajetta E, Dirix LY, Fein LE, Jones SE, Cervek J, et al. Exemestane improves survival compared with megoestrol acetate in postmenopausal patients with advanced breast cancer who have failed on tamoxifen. Results of a double-blind randomised phase III trial. Eur J Cancer 2000;36:S86-7.
    • (2000) Eur J Cancer , vol.36
    • Kaufmann, M.1    Bajetta, E.2    Dirix, L.Y.3    Fein, L.E.4    Jones, S.E.5    Cervek, J.6
  • 80
    • 4944231703 scopus 로고    scopus 로고
    • Superiority of letrozole to tamoxifen in the first-line treatment of advanced breast cancer: Evidence from metastatic subgroups and a test of functional ability
    • Mouridsen H, Sun Y, Gershanovich M, Perez-Carrion R, Becquart D, Chaudri-Ross HA, et al. Superiority of letrozole to tamoxifen in the first-line treatment of advanced breast cancer: evidence from metastatic subgroups and a test of functional ability. Oncologist 2004;9:489-96.
    • (2004) Oncologist , vol.9 , pp. 489-496
    • Mouridsen, H.1    Sun, Y.2    Gershanovich, M.3    Perez-Carrion, R.4    Becquart, D.5    Chaudri-Ross, H.A.6
  • 81
    • 0003016386 scopus 로고    scopus 로고
    • Promising results with exemestane in the first-line treatment of metastatic breast cancer: A randomized phase II EORTC trial with a tamoxifen control
    • Paridaens R, Dirix L, Beex L, Nooij M, Cufer T, Lohrisch C, et al. Promising results with exemestane in the first-line treatment of metastatic breast cancer: a randomized phase II EORTC trial with a tamoxifen control. Clin Breast Cancer 2000;1:S19-21.
    • (2000) Clin Breast Cancer , vol.1
    • Paridaens, R.1    Dirix, L.2    Beex, L.3    Nooij, M.4    Cufer, T.5    Lohrisch, C.6
  • 82
    • 10744222368 scopus 로고    scopus 로고
    • An open randomised trial of second-line endocrine therapy in advanced breast cancer. Comparison of the aromatase inhibitors letrozole and anastrozole
    • Rose C, Vtoraya O, Pluzanska A, Davidson N, Gershanovich M, Thomas R, et al. An open randomised trial of second-line endocrine therapy in advanced breast cancer. Comparison of the aromatase inhibitors letrozole and anastrozole. Eur J Cancer 2003;39:2318-27.
    • (2003) Eur J Cancer , vol.39 , pp. 2318-2327
    • Rose, C.1    Vtoraya, O.2    Pluzanska, A.3    Davidson, N.4    Gershanovich, M.5    Thomas, R.6
  • 83
    • 65649098606 scopus 로고    scopus 로고
    • A comparative study of exemestane versus anastrozole in patients with postmenopausal breast cancer with visceral metastases
    • Campos SM, Guastalla JP, Subar M, Abreu P, Winer EP, Cameron DA. A comparative study of exemestane versus anastrozole in patients with postmenopausal breast cancer with visceral metastases. Clin Breast Cancer 2009;9:39-44.
    • (2009) Clin Breast Cancer , vol.9 , pp. 39-44
    • Campos, S.M.1    Guastalla, J.P.2    Subar, M.3    Abreu, P.4    Winer, E.P.5    Cameron, D.A.6
  • 84
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A, Robertson JF, Quaresma Albano J, Aschermannova A, Mauriac L, Kleeberg UR, et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002;20:3396-403.
    • (2002) J Clin Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.2    Quaresma Albano, J.3    Aschermannova, A.4    Mauriac, L.5    Kleeberg, U.R.6
  • 85
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
    • Osborne CK, Pippen J, Jones SE, Parker LM, Ellis M, Come S, et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol 2002;20:3386-95.
    • (2002) J Clin Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3    Parker, L.M.4    Ellis, M.5    Come, S.6
  • 86
    • 76749091057 scopus 로고    scopus 로고
    • Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: Results from the FIRST study
    • Robertson JF, Llombart-Cussac A, Rolski J, Feltl D, Dewar J, Macpherson E, et al. Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study. J Clin Oncol 2009;27:4530-5.
    • (2009) J Clin Oncol , vol.27 , pp. 4530-4535
    • Robertson, J.F.1    Llombart-Cussac, A.2    Rolski, J.3    Feltl, D.4    Dewar, J.5    McPherson, E.6
  • 87
    • 54449099359 scopus 로고    scopus 로고
    • Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: The European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    • Paridaens RJ, Dirix LY, Beex LV, Nooij M, Cameron DA, Cufer T, et al. Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group. J Clin Oncol 2008;26:4883-90.
    • (2008) J Clin Oncol , vol.26 , pp. 4883-4890
    • Paridaens, R.J.1    Dirix, L.Y.2    Beex, L.V.3    Nooij, M.4    Cameron, D.A.5    Cufer, T.6
  • 88
    • 66149083297 scopus 로고    scopus 로고
    • Randomized phase III trial of exemestane or tamoxifen in first-line hormonal treatment of postmenopausal women with metastatic breast cancer
    • Chernozemsky I, Kalinov K, Tzekov H, Racheva M, Hristova S, Tomova A, et al. Randomized phase III trial of exemestane or tamoxifen in first-line hormonal treatment of postmenopausal women with metastatic breast cancer. Breast Cancer Res Treat 2007;106:S119.
    • (2007) Breast Cancer Res Treat , vol.106
    • Chernozemsky, I.1    Kalinov, K.2    Tzekov, H.3    Racheva, M.4    Hristova, S.5    Tomova, A.6
  • 89
    • 69049097227 scopus 로고    scopus 로고
    • Activity of fulvestrant versus exemestane in advanced breast cancer patients with or without visceral metastases: Data from the EFECT trial
    • Mauriac L, Romieu G, Bines J. Activity of fulvestrant versus exemestane in advanced breast cancer patients with or without visceral metastases: data from the EFECT trial. Breast Cancer Res Treat 2009;117:69-75.
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 69-75
    • Mauriac, L.1    Romieu, G.2    Bines, J.3
  • 90
    • 0034128928 scopus 로고    scopus 로고
    • Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: Results of a phase III randomized double-blind trial
    • Kaufmann M, Bajetta E, Dirix LY, Fein LE, Jones SE, Zilembo N, et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. J Clin Oncol 2000;18:1399-411.
    • (2000) J Clin Oncol , vol.18 , pp. 1399-1411
    • Kaufmann, M.1    Bajetta, E.2    Dirix, L.Y.3    Fein, L.E.4    Jones, S.E.5    Zilembo, N.6
  • 92
    • 0033805663 scopus 로고    scopus 로고
    • Cost utility analysis of second line hormonal therapy in advanced breast cancer: A comparison of two aromatase inhibitors to megestrol acetate
    • Dranitsaris G, Leung P, Mather J, Oza A. Cost utility analysis of second line hormonal therapy in advanced breast cancer: a comparison of two aromatase inhibitors to megestrol acetate. Anticancer Drugs 2000;11:591-601.
    • (2000) Anticancer Drugs , vol.11 , pp. 591-601
    • Dranitsaris, G.1    Leung, P.2    Mather, J.3    Oza, A.4
  • 93
    • 0038178935 scopus 로고    scopus 로고
    • Cost utility analysis of first-line hormonal therapy in advanced breast cancer
    • Dranitsaris G, Verma S, Trudeau M. Cost utility analysis of first-line hormonal therapy in advanced breast cancer. Am J Clin Oncol 2003;26:289-96.
    • (2003) Am J Clin Oncol , vol.26 , pp. 289-296
    • Dranitsaris, G.1    Verma, S.2    Trudeau, M.3
  • 94
    • 9644256101 scopus 로고    scopus 로고
    • Cost utility and budget impact of third-generation aromatase inhibitors for advanced breast cancer: A literature based model analysis of cost in the Italian national health service
    • Marchetti M, Caruggi M, Colombo G. Cost utility and budget impact of third-generation aromatase inhibitors for advanced breast cancer: a literature based model analysis of cost in the Italian national health service. Clin Ther 2004;26:1546-61.
    • (2004) Clin Ther , vol.26 , pp. 1546-1561
    • Marchetti, M.1    Caruggi, M.2    Colombo, G.3
  • 95
    • 0242413719 scopus 로고    scopus 로고
    • Economic evaluation of antiaromatase agents in the second line treatment of metastatic breast cancer
    • Verma S, Rodchi A. Economic evaluation of antiaromatase agents in the second line treatment of metastatic breast cancer. Support Care Cancer 2003;11:728-34.
    • (2003) Support Care Cancer , vol.11 , pp. 728-734
    • Verma, S.1    Rodchi, A.2
  • 97
    • 80755180389 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (NICE), London: National Institute for Health and Clinical Excellence, URL:, (accessed 26 January 2010)
    • National Institute for Health and Clinical Excellence (NICE). Guide to the methods of technology appraisal. London: National Institute for Health and Clinical Excellence; 2008. URL: www.nice.org.uk/media/B52/A7/TAMethodsGuideUpdatedJune2008.pdf (accessed 26 January 2010).
    • (2008) Guide to the methods of technology appraisal
  • 98
    • 42149127173 scopus 로고    scopus 로고
    • Kent: Personal Social Services Research Unit, University of Kent, URL:, (accessed 25 August 2010)
    • Curtis L. Unit costs of health and social care 2008. Kent: Personal Social Services Research Unit, University of Kent; 2008. URL: www.pssru.ac.uk/uc/uc2008contents.htm (accessed 25 August 2010).
    • (2008) Unit costs of health and social care 2008
    • Curtis, L.1
  • 99
    • 79960701382 scopus 로고    scopus 로고
    • Department of Health, URL:, (accessed 25 August 2010)
    • Department of Health. NHS reference costs 2008-2009. 2010. URL: www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_111591 (accessed 25 August 2010).
    • (2010) NHS reference costs 2008-2009
  • 100
    • 3342971378 scopus 로고    scopus 로고
    • Cost of managing women presenting with stage IV breast cancer in the United Kingdom
    • Remak E, Brazil L. Cost of managing women presenting with stage IV breast cancer in the United Kingdom. Br J Cancer 2004;91:77-83.
    • (2004) Br J Cancer , vol.91 , pp. 77-83
    • Remak, E.1    Brazil, L.2
  • 101
    • 0027407786 scopus 로고
    • The functional assessment of cancer therapy scale: Development and validation of the general measure
    • Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, et al. The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 1993;11:570-9.
    • (1993) J Clin Oncol , vol.11 , pp. 570-579
    • Cella, D.F.1    Tulsky, D.S.2    Gray, G.3    Sarafian, B.4    Linn, E.5    Bonomi, A.6
  • 102
    • 34447561734 scopus 로고    scopus 로고
    • Estimation of patient preference-based utility weights from the functional assessment of cancer therapy-general
    • Dobrez D, Cella D, Pickard S, Lai J-S, Nickolov A. Estimation of patient preference-based utility weights from the functional assessment of cancer therapy-general. Value Health 2007;10:266-72.
    • (2007) Value Health , vol.10 , pp. 266-272
    • Dobrez, D.1    Cella, D.2    Pickard, S.3    Lai, J.-S.4    Nickolov, A.5
  • 103
    • 84856323626 scopus 로고    scopus 로고
    • Patient preference-based utility weights from the Functional Assessment of Cancer Therapy-general (FACT-G) in women with hormone receptor positive metastatic breast cancer receiving letrozole plus lapatinib or letrozole alone
    • Abstract PCN0105
    • Delea TE et al. Patient preference-based utility weights from the Functional Assessment of Cancer Therapy-general (FACT-G) in women with hormone receptor positive metastatic breast cancer receiving letrozole plus lapatinib or letrozole alone. Value Health 2010;3:43 Abstract PCN0105.
    • (2010) Value Health , vol.3 , pp. 43
    • Delea, T.E.1
  • 106
    • 56949106092 scopus 로고    scopus 로고
    • Health state utility scores in advanced non-small cell lung cancer
    • Doyle S, Lloyd A, Walker M. Health state utility scores in advanced non-small cell lung cancer. Lung Cancer 2009;62:374-80.
    • (2009) Lung Cancer , vol.62 , pp. 374-380
    • Doyle, S.1    Lloyd, A.2    Walker, M.3
  • 107
    • 70349241801 scopus 로고    scopus 로고
    • Trastuzumab for the treatment of primary breast cancer in HER2-positive women: A single technology appraisal
    • Ward S, Pilgrim H, Hind D. Trastuzumab for the treatment of primary breast cancer in HER2-positive women: a single technology appraisal. Health Technol Assess 2009;13(Suppl. 1):1-6.
    • (2009) Health Technol Assess , vol.13 , Issue.SUPPL. 1 , pp. 1-6
    • Ward, S.1    Pilgrim, H.2    Hind, D.3
  • 108
    • 42149127173 scopus 로고    scopus 로고
    • Personal Social Services Research Unit, University of Kent, URL:, (accessed 25 August 2010)
    • Curtis L. Unit costs of health and social care 2009. Personal Social Services Research Unit, University of Kent; 2010. URL: www.pssru.ac.uk/uc/uc2009contents.htm (accessed 25 August 2010).
    • (2010) Unit costs of health and social care 2009
    • Curtis, L.1
  • 109
    • 0141922990 scopus 로고    scopus 로고
    • A bayesian approach to markov modelling in cost effectiveness analyses: Application to taxane use in advanced brest cancer
    • Cooper N, Abrams K, Sutton A, Turner D, Lambert P. A bayesian approach to markov modelling in cost effectiveness analyses: application to taxane use in advanced brest cancer. J Roy Statistical Society 2003;166:389-405.
    • (2003) J Roy Statistical Society , vol.166 , pp. 389-405
    • Cooper, N.1    Abrams, K.2    Sutton, A.3    Turner, D.4    Lambert, P.5
  • 110
    • 84889754773 scopus 로고    scopus 로고
    • Regional Drugs and Therapeutics Centre, URL:, (accessed 25 August 2010)
    • Regional Drugs and Therapeutics Centre. The use of bevacizumab in the manaagment of metastatic breast cancer. 2007. URL: www.nyrdtc.nhs.uk/docs/eva/Bevacizumab%20MBC%20RDTC%20FINAL.pdf (accessed 25 August 2010).
    • (2007) The use of bevacizumab in the manaagment of metastatic breast cancer
  • 112
    • 0030102792 scopus 로고    scopus 로고
    • The time trade-off method: Results from a general population survey
    • Dolan P, Gudex C, Kind P, Williams A. The time trade-off method: results from a general population survey. Health Econ 1996;5:141-54.
    • (1996) Health Econ , vol.5 , pp. 141-154
    • Dolan, P.1    Gudex, C.2    Kind, P.3    Williams, A.4


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