Bactericidal properties of pradofloxacin against veterinary pathogens

Veterinary Microbiology

Volumn 157, Issue 1-2, 2012, Pages 106-111

  Silley, Peter ^a,b   Stephan, Bernd ^c   Greife, Heinrich A ^c   Pridmore, Andrew ^d  

^a MB Consult Limited   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c BAYER PHARMA AG   (Germany)

^d Don Whitley Scientific Ltd   (United Kingdom)

Author keywords

Bactericidal; Fluoroquinolones; Kill kinetics; Pradofloxacin

Indexed keywords

PRADOFLOXACIN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; BACTEROIDES FRAGILIS; CAT; DILUTION; DOG; EGGERTHELLA LENTA; ESCHERICHIA COLI; FUSOBACTERIUM; FUSOBACTERIUM NUCLEATUM; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PASTEURELLA MULTOCIDA; PORPHYROMONAS GINGIVALIS; PREVOTELLA; PROTEUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INTERMEDIUS; STREPTOCOCCUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA, ANAEROBIC; BACTERIAL INFECTIONS; CATS; DOGS; FLUOROQUINOLONES; MICROBIAL SENSITIVITY TESTS;

ANIMALIA; BACTERIA (MICROORGANISMS); CANIS FAMILIARIS; ESCHERICHIA COLI; FUSOBACTERIUM; PASTEURELLA MULTOCIDA; PORPHYROMONAS GINGIVALIS; PREVOTELLA; PROTEUS (ENTEROBACTERIA); STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS PSEUDINTERMEDIUS; STREPTOCOCCUS CANIS;

EID: 84859726606     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2011.11.027     Document Type: Article

References (24)

1. Asuquo A.E., Piddock L.J.V. Accumulation and killing kinetics of fifteen quinolones for Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. J. Antimicrob. Chemother. 1993, 31:865-880.
2. Barry A.L. In vitro activity of the quinolones and related compounds. The New Generation of Quinolones 1990, 79-105. Marcel Dekker, New York. C. Siporin, C.L. Heifetz, J.M. Domagala (Eds.).
3. Blondeau J.M., Borsos S., Blondeau L.D., Blondeau B.J. In vitro killing of Escherichia coli, Staphylococcus pseudintermedius and Pseudomonas aeruginosa by enrofloxacin in combination with its active metabolite ciprofloxacin using clinically relevant drug concentrations in the dog and cat. Vet. Microbiol. 2011, 10.1016/j.vetmic.2011.08.015.
4. Carret G., Flandrois J.P., Lobry J.R. Biphasic kinetics of bacterial killing by quinolones. J. Antimicrob. Chemother. 1991, 27:319-327.
5. CLSI (1999) NCCLS. Methods for Determining Bactericidal Activity of Antimicrobial Agents; Approved Guideline, vol. 19, no. 18, NCCLS document M26-A. CLSI, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087, USA.
6. Cohen M.A., Huband M.D., Yoder S.L., Gag J.W., Roland G.E. Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies. J. Antimicrob. Chemother. 1998, 41:605-614.
7. Coulet M., van Borssum Waalkes M., Cox P., Lohuis J. In vitro and in vivo pharmacodynamic properties of the fluoroquinolone ibafloxacin. J. Vet. Pharmacol. Therap. 2002, 25:401-411.
8. Drlica K., Hooper D.C. Mechanisms of quinolone action. Quinolone Antimicrobial Agents 2003, 19-40. ASM Press, Washington, DC, USA, Chapter 2. 3rd ed. D.C. Hooper, E. Rubinstein (Eds.).
9. Drlica K., Malik M. Fluoroquinolones: action and resistance. Curr. Topics Med. Chem. 2003, 3:249-282.
10. Drlica K., Malik M., Kerns R.J., Zhao X. Quinolone-mediated bacterial death. Antimicrob. Agent. Chemother. 2008, 52:385-392.
11. Elliott T.S.J., Shelton A., Greenwood D. The response of Escherichia coli to ciprofloxacin and norfloxacin. J. Med. Microbiol. 1987, 23:83-88.
12. Ganière J.-P., Médaille C., Etoré F. In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections. Res. Vet. Sci. 2004, 77:67-71.
13. Goldstein E.J.C. Possible role for the new fluoroquinolones levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a in the treatment of anaerobic infections: review of current information on efficacy and safety. Clin. Infect. Dis. 1996, 23(Suppl. 1):S25-S30.
14. Hawkey P.M. Mechanisms of quinolone action and microbial response. J. Antimicrob. Chemother. 2003, 51(S1):29-35.
15. Lu T., Zhao X., Li X., Drlica-Wagner A., Wang J.-Y., Domagala J., Drlica K. Enhancement of fluoroquinolone activity by C-8 halogen and methoxy moieties: action against a gyrase resistance mutant of Mycobacterium smegmatis and a gyrase-topoisomerase IV double mutant of Staphylococcus aureus. Antimicrob. Agent. Chemother. 2001, 45:2703-2709.
16. Malik M., Hussain S., Drlica K. Effect of anaerobic growth on quinolone lethality with Escherichia coli. Antimicrob. Agent. Chemother. 2007, 51:28-34.
17. Mueller M., de la Peña A., Derendorf H. Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC. Antimicrob. Agent. Chemother. 2004, 48:369-377.
18. Schentag J.J., Nix D.E., Forrest A. Pharmacodynamics of the fluoroquinolones. Quinolone Antimicrobial Agents 1993, 259-271. American Society for Microbiology, Washington, DC, Chapter 12. 2nd ed. D.C. Hooper, J.S. Wolfson (Eds.).
19. Silley P., Stephan B., Greife H.A., Pridmore A. Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats. J. Antimicrob. Chemother. 2007, 60:999-1003.
20. Stephan B., Friederichs S., Pridmore A.A. Novel fluoroquinolone pradofloxacin: clinical efficacy and safety in the treatment of feline wound infections. J. Vet. Pharmacol. Therap. 2006, 29(Suppl. 1):77-78.
21. Stephan B., Greife H.A., Pridmore A., Silley P. Mutant prevention concentration of pradofloxacin against Porphyromonas gingivalis. Vet. Microbiol. 2007, 121:194-195.
22. Wetzstein H.-G. Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance. Antimicrob. Agent. Chemother. 2005, 49:4166-4173.
23. Wetzstein H.-G., Hallenbach W. Relative contributions of the C-7 amine and the C-8 cyano substituents to the antibacterial potency of pradofloxacin. Proceedings of the 104th Annual General Meeting, American Society for Microbiology, abstract Z-026 2004, 672-673.
24. Wolfson J.S., Hooper D.C. Fluoroquinolone antimicrobial agents. Clin. Microbiol. Rev. 1989, 2:378-424.